Background: High-fidelity patient simulation is often used to teach clinical patient management and decision-making with small groups. This pilot project determined feasibility for large-group educational presentations using simulation for preclinical basic science courses.Methods: We developed an emergency patient simulation encounter illustrating basic neuroscience concepts. Physician actors interacted with a high-fidelity simulated patient mannequin in a lecture hall. First and second year medical students were active participants in the 90 minute live event in large groups. Digital video was recorded and written feedback was obtained from participants.Results: The simulation was presented four times to a total of 202 students. Video review demonstrated extensive interaction within the large groups. Case management discussions included basic science topics, autonomic pathways, and neuropharmacology. Student feedback revealed 98% rated the correlation to basic science concepts as very good or outstanding, and 99% rated the same for overall presentation.Conclusions: Live large-group simulation presentations are feasible in a non-traditional location, correlate with basic science in the preclinical medical curriculum, and are well-received by students.