Iliac vein stenting of nonthrombotic iliac vein lesions is currently considered one of the treatment options for managing chronic venous insufficiency. Previous investigations have focused on the efficacy and thrombosis of this procedure, but we noted that our most common postoperative complication is low back pain after stent placement. We investigated whether the use of intravenous (IV) intraoperative sedation would play a role in reducing this pain in our patients postoperatively. Data regarding postoperative pain were collected during a 59-month period for a population of 2051 patients. The average age was 64.89 years (range, 27-99 years; standard deviation [SD], ±14.07 years), with 1261 female and 790 male patients. Before August 2016, patients did not receive IV sedation and instead received a 1% local lidocaine injection within the skin and subcutaneous layers of the operation site. After August 2016, patients received either a lidocaine injection or IV sedation (with varying amounts of lidocaine, fentanyl, ketorolac, propofol, and midazolam). A pain scale, ranging from 0 to 10, was used within 1 hour postoperatively to assess the severity of pain experienced by the respective patient groups. A total of 1685 patients underwent the procedure without IV sedation and reported an average pain score of 1.47 (range, 0-10; SD, ± 2.44). The remaining 366 patients received IV sedation and reported low back pain with an average pain score of 1.12 (range, 0-10; SD, ± 2.41). The 95% confidence interval of our data set ranged from −0.6258 to −0.0742 (P = .0127). Our data suggest that the use of IV intraoperative sedation plays a role in reducing low back pain in our patients postoperatively after stent placement.