Non-specific Stressors Research Articles

Orosomucoid in schizophrenia.

OROSOMUCOID, a glycoprotein extremely rich in carbohydrate, is the principal constituent of the perchloric acid-soluble seromucoid fraction of human serum1. In contrast to the seromucoid fraction which contains several proteins and represents more than one biological entity, orosomucoid is homogeneous and behaves as a single protein. With the production of specific chicken antiorosomucoid sera2,3, it has become possible to investigate the clinical significance of orosomucoid. Interest in doing so arises from the fact that elevations of seromucoid and total serum glycoprotein-levels occur in a number of diseases; for example, in malignancy, tuberculosis, rheumatoid arthritis, and multiple sclerosis4. Elevations in this chemically defined group of proteins also occur in response to a wide range of non-specific stressors such as fractures, epinephrine injection, and burns5.