Active metamaterials with embedded control allow reconfiguring of the physical properties needed for wave propagation control. This flexibility provides useful features important for various waveguiding applications. Previous approaches to active metamaterials could change the material properties; however, their overall physical properties remained static. Time-modulated metamaterials, which can change physical properties dynamically, have recently attracted great interest. In this work, we present a time-varying, non-reciprocal, reconfigurable metasurface, which achieves active switching control of the field-localized waveguide. An experimental demonstration of the non-reciprocal metasurface is presented using two examples of sub-wavelength waveguides operating at 13 MHz and 13.5 MHz. The dynamic reconfiguring capability provides a wide range of versatile, practical applications, overcoming static passive metamaterials’ limitations. Because the waveguide’s location and shape can be controlled readily, the proposed method can be used for a broad range of applications that require dynamic wave propagation control.