We calculate open heavy-flavor (HF) transport in relativistic heavy-ion collisions by applying a strong-coupling treatment in both macro- and microscopic dynamics (hydrodynamics and non-perturbative diffusion interactions). The hydrodynamic medium evolution is quantitatively constrained by bulk and multi-strange hadron spectra and elliptic flow. The heavy quark transport coefficient is evaluated from a non-perturbative T-matrix approach in the Quark–Gluon Plasma which, close to the critical temperature, leads to resonance formation and feeds into the recombination of heavy quarks on a hydrodynamic hypersurface. In the hadronic phase, the diffusion of HF mesons is obtained from effective hadronic theory. We compute observables at RHIC and LHC for non-photonic electrons and HF mesons, respectively.