non-Newtonian Model Research Articles

Numerical computation of pulsatile hemodynamics and diagnostic concern of coronary bifurcated artery flow for Newtonian and non-Newtonian fluid

Atherosclerotic with the high occurrence of plaque formation due to stenosis has attracted wide attention among researchers. The left coronary artery has been studied in two-dimensional and in three-dimensional (3D) bifurcation as the models of blood flow through Newtonian and non-Newtonian fluids to better understand the physical mechanism. The computational Fluid Dynamics (CFD) technique is incorporated in COMSOL Multiphysics and then it is justified by satisfactory validation. It is found that the Newtonian model shows larger recirculation zones than non-Newtonian does. The present study also focuses on the evaluations of the lesion of diagnostic and the coefficient of pressure drop assessments on the basis of the diagnostic parameter’s critical values affected by the rheological model. Nevertheless, the leading concentration of the subsisting investigation works is confined to the change of importance factor (IFc) affected by arterial blockage. But the IFc of non-Newtonian fluid for 3D left coronary artery bifurcation model decreases with increasing bifurcation angle and the time-averaged inlet pressure is the least for smaller bifurcation angles. The current research further concentrates that the flow separation length reduces with developing bifurcation angle in bifurcated geometry. It is significant to mention that non-Newtonian blood flow model incorporating hemodynamic and diagnostic parameters has great impacts on instantaneous flow systems.

A fractional model of magnetohydrodynamics Oldroyd-B fluid with couple stresses, heat and mass transfer: A comparison among Non-Newtonian fluid models

The present article aims to extend some of the already existing fluid models to a large class of fluids namely, “Oldroyd-B couple stress fluid (OBCSF)”. The main focus of the present work is to combine the existing fluid models in ordered to get a new class of fluid. The unsteady magnetohydrodynamics (MHD) Oldroyd-B fluid (OBF) with couple stresses, porosity, heat and mass transfer is considered in the present analysis. The Oldroyd-B couple stress fluid is assumed to flow in channel. The classical model is fractionalized by considering Atangana-Baleanu (AB) operator in ordered to highlight the memory analysis. To develop closed form solutions the combined (Laplace + Fourier) integrals have been used. The results obtained are portrayed through graphs for all pertinent flow parameters which involved in the present dynamic model. Moreover, the impact of AB time fractional parameter is investigated graphically on flow, temperature and concentration distributions exploiting MATHCAD software. Secondly, for better understanding the present solutions of Oldroyd-B couple stress fluid (OBCSF) are reduced to Odroyd-B fluid (OBF) without couple stresses, Maxwell solutions, Couple stress solutions and Newtonian viscous fluid solutions and the results have been compared for classical and fractional order derivatives. In addition to this a limiting case is carried out by our solutions to already published work which verify our solutions. In addition to this during the analysis we noticed that the flow heat and concentrated get lowered for the escalating numerical values of AB fractional derivatives. Similarly, it is also noticed that the velocity in channel accelerated with the increment of numeric values of pressure, porosity, thermal buoyancy and relaxation time parameter. In the same manner temperature and concertation profiles gets low with the higher values of Prandtl number, Reynold number and fractional operator. Finally, skin friction for momentum equation, Nusselt number for temperature and Sherwood number for concentration have been calculated and given in tabular forms.

Performance analysis of annular disks with non-Newtonian Rabinowitsch fluid model: Influence of squeeze film pressure, surface roughness, porosity and viscosity variation

In various systems of energy, such as turbo-machinery and viscous-lock system, squeeze film plays a crucial role for improving transport systems. The importance of the aforementioned applications led us to explore the physical behavior of Rabinowitsch fluid flow for several values of viscosity, [Formula: see text], load capacity [Formula: see text], nonlinear factor, [Formula: see text], dimensionless film thickness [Formula: see text], dimensionless radius of the capillary tube [Formula: see text], dimensionless thickness of porous pad [Formula: see text]), inner and outer radius ratio [Formula: see text], roughness parameter [Formula: see text] through a squeeze film with two rough porous annular discs. Five-point Gauss quadrature integral formula has been used to examine the characteristics of annular discs, and small perturbation method has been used to discretize the governing Rabinowitsch fluid flow (RFF) equations. The modified Reynolds equation for rough, porous and viscosity change with film thickness is developed using Christensen’s stochastic theory, modified Darcy’s theory and the association between viscosity and film thickness agreement. The impacts of [Formula: see text] on the behavior of porosity and viscosity variability of RFF have been visually depicted in terms of film pressure, load capacity and squeeze reaction time of annular discs. It has been determined that for RFF with variable viscosity and roughness parameter on a porous media, the performance of the annular disks enhances for [Formula: see text] (dilatant lubricant), and diminishes for [Formula: see text] (pseudo-plastic lubricant). It has been found that the film pressure in case of dilatant lubricant is increased by the influence of Rabinowitsch fluids on porous walls, but the behavior of pseudo-plastic lubricants has an opposite tendency relative to Newtonian lubricants. It has also been found that the impact of variability in porosity, roughness and viscosity diminishes the load-carrying capacity (LCC) with increased film thickness than the case of nonporous, smooth surface and constant viscosity of Rabinowitsch fluid.

Rheological Study of Formate (Nacl) and Ethylene Glycol Based Drilling Fluid Using MATLAB

Non-Newtonian models are used in describing the rheology of drilling fluids. Models, such as Power Law, Bingham Plastic, and the Hershel-Buckley model are used to predict drilling fluid behaviour. Selection of the best rheological model that accurately represents the shear stress-shear rate data is optimal in determining fluid use and predicting realistic rheological behaviour. This research is aimed at studying the best rheology model to fit collected data from sodium chloride (NaCl) and ethylene glycol (EG) based drilling fluid. The assessment utilized a total of ten sets of experimental viscometry data from laboratory-formulated drilling fluid samples A to J with the varying volume of formate sodium chloride (NaCl) and ethylene glycol (EG). Using Equations relating shear rates to shear stress, MATLAB non-linear regression approach was used to determine the best of the three rheological models to fit the experimental. The Root square (R2), Adjusted Root square (Adj R2), and Root Mean Square Error (RMSE) were used in determining the goodness of fit and degree of deviation of the experimental data. data. High concentrations of both NaCl and ethylene glycols in the formulation provide a better shear rate shear stress fit. Although the ethylene glycol presence may have account for the improved fit, as Sample E, F and G despite containing high volume of the formate NaCl, the data where not effectively fitted by the models. From the results, the power law model was the least suitable with an R2 value of 0.881-0.956, Adj R2 83-96%, and a poor RSME in the range 2-9. The Herschel-Bulkley model showed an improved fit for the fluids with an R2 0.897-0.973, Adj R287- 98%, and a better RSME <3. this model also shows a good shear thinning behaviour from its three parameter consistency (n) index values. The Bingham plastic model best fits the rheology of the drilling fluid data R2 0.93-0.99, Adj R2 93-98%, and RSME of <2.

Effects of stenosis and aneurysm on blood flow in stenotic-aneurysmal artery

Blood is indeed a suspension of the different type of cells along with shear thinning, yield stress and viscoelastic characteristics, which can be expressed by Newtonian and a lot of non-Newtonian models. Choosing Newtonian fluid as a sample, an unsteady solver for Newtonian fluid is constructed to determine the transient flow of blood in the obscure region. In this probe, the computational unsteady flow of blood in artery with aneurysm and symmetric stenosis has been considered, which is novelty of current research. The results of this investigation can be applied to detect stenotic-aneurysmal diseases and enhance knowledge of the stenotic-aneurysmal artery, which may increase the understanding of medical science. The blood artery is modeled as a circular tube having a 0.3-m radius and a 2-m length along the horizontal axis. The velocity of blood is taken at 0.12 ms−1 so that the geometry satisfies the characteristics of the blood vessel. The governing mass and momentum equations are then solved by finite difference technique of discretization. In this research, important variations in blood pressure and velocity at stenosis and aneurysms in the artery are found. The significant influences on blood flow of the stenotic-aneurysmal artery for pressure and velocity profiles of blood are displayed graphically for the Newtonian model.

Significance of chemically reactive magnetized Eyring-Powell nanofluid flow comprising gyrotactic moment of microorganism and radiative analysis

The emerging attention in nano-technology and thermal engineering has led to the concept of nanoparticles with improved theoretical mechanisms and accomplished influenced innovative usages in cooling and heating conveniences, air conditioning arrangements, heat carrying systems, bio-medical applications such as cancer cure, micromechanics, solar energy, artificial heart surgery etc. Currently, peristaltic movements joined with non-Newtonian fluids have enlarged innumerable devotion due to their enormous applications in physical, medical, engineering processes and medical. Eyring - Powell is unique type of non-Newtonian model consequential commencing the theory of motion of fluids. This research work inspects the 3D steady magnetohydrodynamic flow (MHD) containing microorganisms of a Powell-Eyring nanofluid with double stratification over a bidirectional stretched surface. Furthermore, the characteristics of the heat transfer phenomenon are prescribed out by means of thermal radiation. For changing nonlinear PDEs to nonlinear ODEs, we use the appropriate transformations and then numerically solve them with the help of bvp4c procedures. The possessions of several parameters modulating the heat and mass transfer properties are graphically depicted and illustrated in particular. It is interesting to perceived that the temperature field deteriorates for established estimates of the stretching parameter and the Prandtl number. The microorganism as well as concentration field improve for increasing estimates of magnetic parameter and the Biot number.

Numerical and experimental study of influence function in magnetorheological finishing (MRF) of freeform surface

In the present work, a dynamic viscosity model is proposed based on the varying magnetic flux density of the neodymium permanent magnet along its width. The proposed viscosity model is helpful in analysing the influence function in a better way as compared to standard non-Newtonian fluid models. During the finishing process, the research of influence function aids in establishing the right range of process parameters. MR fluid flow on the freeform surface is examined numerically and experimentally to better understand the influence function. The flow behaviour of the MR fluid is investigated using the three-dimensional (3D) computational fluid dynamics (CFD) simulation, wall shear stress and dynamic pressure are estimated on the Oxygen-free high conductivity (OFHC) copper for various process parameters (working gap and rotational speed). On the convex and concave sections of a freeform surface, indentation depth is estimated for various process parameters using the results of dynamic pressure and empirical relation. Finishing tests are performed to investigate forces (tangential and normal) and indentation depth on the workpiece, and the results are evaluated.

Similar construction method for non-Newtonian power-law fluid seepage models with elastic outer boundary conditions

Similar construction method for non-Newtonian power-law fluid seepage models with elastic outer boundary conditions

An unsteady bioconvective non-Newtonian nanofluid model with variable thermal properties and modified heat flux framework

The suspension nanoparticles in non-Newtonian materials convey different applications in the thermal systems, engineering processes, industrial energy developments, extrusion systems, solar system, etc. It is commonly observed that the thermal properties in the various base materials fluctuated and cannot be assumed to be constants. A decomposition of nanofluids is fluctuated and cannot considered as a constant. The objective of this communication is to inspect the thermal mechanism of non-Newtonian nanofluids due to accelerated frame in view of variable thermal conductivity. The modified mathematical relations for Fourier and Fick theories are utilized to model the problem. The nanofluids contain the microorganisms to ensure the thermal stability. The problem is modeled in nonlinear partial differential system which is further communicated via HAM. The convergent analysis is ensured and later on physical illustrations to problem in view of parameters are discussed. It is observed that thermal phenomenon controls due to mixed convection parameter while increasing impact for Williamson fluid parameter is observed. The magnitude of oscillation of Nusselt number due to Prandtl number is enhanced without any phase difference. The obtained results may convey different engineering applications like extrusion systems, chemical processes, thermal management systems, heating and cooling application, plasma, manufacturing processes.

The effects of non-Newtonian blood modeling and pulsatility on hemodynamics in the food and drug administration's benchmark nozzle model.

Computational fluid dynamics (CFD) is an important tool for predicting cardiovascular device performance. The FDA developed a benchmark nozzle model in which experimental and CFD data were compared, however, the studies were limited by steady flows and Newtonian models. Newtonian and non-Newtonian blood models will be compared under steady and pulsatile flows to evaluate their influence on hemodynamics in the FDA nozzle. CFD simulations were validated against the FDA data for steady flow with a Newtonian model. Further simulations were performed using Newtonian and non-Newtonian models under both steady and pulsatile flows. CFD results were within the experimental standard deviations at nearly all locations and Reynolds numbers. The model differences were most evident at Re =500, in the recirculation regions, and during diastole. The non-Newtonian model predicted blunter upstream velocity profiles, higher velocities in the throat, and differences in the recirculation flow patterns. The non-Newtonian model also predicted a greater pressure drop at Re =500 with minimal differences observed at higher Reynolds numbers. An improved modeling framework and validation procedure were used to further investigate hemodynamics in geometries relevant to cardiovascular devices and found that accounting for blood's non-Newtonian and pulsatile behavior can lead to large differences in predictions in hemodynamic parameters.

Effects of Anastomotic Angles and Distances of the Bypass Graft to the Stenosis on Blood Flow Hydrodynamics in a Bypass Grafting Coronary Artery

It is believed that the proper distance between the grafting location and the stenosis location and the appropriate angle of graft or transplantation in the blocked artery of the heart are two important factors in the removal or decrease of reappearance and re-development of intimal hyperplasia (IH), blood clotting, and re-blockage of the surgical artery. In the present study, a 3-D geometry of the host coronary artery as non-elastic with 75% symmetric axial cross-sectional area reduction is considered. The main assumptions were incompressible, laminar, steady-state, Newtonian, and non-Newtonian (with Herschel Bulkley model) blood flow. The 3-D Navier-Stokes equations coupled with the non-Newtonian constitutive model were solved numerically using a finite volume method with the procedure of the SIMPLE program. Shear stress distribution was obtained on the areas of potential re-obstruction and the occurrence of IH such as the Toe, Heel, arterial bed, suture location, and graft artery walls. Based on the results, the distribution of wall shear stress near the Heel, Toe location, and the intersection of the host and graft arteries suddenly increased dramatically. Wall shear stress (WSS) distribution was obtained in the areas of hyperplasticity re-incidence for some important anastomosis angles of grafted arteries, i.e. α=35°,45°,65°,75°. In addition, the increase in the angle of the graft artery caused a sharp increase in the shear stress on the area after the graft and the arterial bed in front of the branching region, and the shear stress decreases in the pre-graft region. Therefore, the excessive angle of the graft artery can cause damage to the arterial endothelial cells in the surrounding suture region.

Capillary non-Newtonian seepage model of unvulcanized rubber expressed by the four-parameter rheological flow

Micro-bubbles and pores in a tire, generated by the seepage process of rubber into steel cord, seriously degrade the safety of the tire in use. However, unclear seepage behavior of unvulcanized rubber while flowing into the interstice of steel cord makes it difficult to eliminate defects. Here, we studied the seepage behavior of unvulcanized rubber in a single capillary. When the four-parameter rheological flow was compared to the common shear rheological model, it was best suited to represent the rheological behavior of unvulcanized rubber because of its lowest variance. On this basis, the single capillary seepage equation of unvulcanized rubber was developed to interpret the relationship between the flow rate, process length, pressure, and pore diameter in a single capillary tube. And it was validated by the finite element analysis method with the four-parameter rheological equation as the material parameter; the accuracy of the single capillary seepage equation reached 99.95%. It lays a foundation for further exploring the seepage model under complex conditions such as variable aperture and multiple channels.

P21: Generalized blood rheological model for analyzing thrombus formation in venous valve architecture

The health impact of venous thromboembolism (VTE), a major cause of morbidity and mortality, can be appreciated from the large number of people affected, 1 million Americans and > 700,000 Europeans annually. The economic impacts of this have been the focus of several studies, with the annual cost to the US healthcare system of incident VTE being estimated at up to $10 billion. The non-Newtonian, shear-thinning blood rheology plays a major role in determining the shape and duration of stagnant fluid zones arising within the venous valve leaflet pockets where the thrombi occur. It has also been suggested that valve compression treatment ensuring oscillating shear stress at the vein wall within the pocket can prevent the formation of clots. Many models have been proposed for blood rheology, some with yield stress and others not, and these have been used extensively to model wall shear stress in models of coronary arteries, with a view to determining the likelihood of stenoses. In this new work, we propose a new non-Newtonian model whose parameters can be readily determined using a capillary rheometer. The model takes the form σ = σ0 + k εn + µ∞ ε where σ is the shear stress and is the ε shear strain rate. σ0 is the yield stress and the fluid viscosity at a high shear strain rate. This generalizes three of the existing models and eliminates the unphysical characteristics of each individual model. This model incorporates the Herschel-Bulkley, Casson, and K-L models as special cases. The overall aim of the work is to determine the effect of venous valve geometry on the likelihood of clot formation, using a realistic description of blood rheology.

Effect of external magnetic field on realistic bifurcated right coronary artery hemodynamics

Diagnostic technology based on magnetic fields is commonly used in medicine for diagnosis and therapy. However, the exposure to strong electromagnetic fields has adverse outcomes in patients. Thus, the objective of the current study is to investigate the effect of applying external uniform magnetic fields on the blood flow in both healthy and diseased cases of right coronary artery and determine the safe values of the applied magnetic field strengths. The diseased cases include a 40% stenosed artery along with two blood disorder cases with a hematocrit level of 20% and 60%. A comprehensive three-dimensional steady non-Newtonian flow model is developed using the Casson model to investigate the effect of the magnetic field on both shear rate and hematocrits. The model is numerically simulated at different values of magnetic field strengths and its orientation. The results indicated that the magnetic field in the Y-direction has a dominant effect compared to other directions. Moreover, the maximum increase in the main branch mass flow rate fraction is about 6.2%. Another interesting finding is that the wall shear stress is slightly affected by the magnetic field strength. For the stenosed case, it is found that the high magnetic field strengths can reduce the formulation of the vortices and hence reduce the risk of thrombosis, which agrees with published works. Additionally, the obtained results confirm that using a magnetic field up to 11.7 T, which is used in magnetic resonance imaging devices, is safe, and has a slight effect on blood flow parameters such as the wall shear stress.

Computational Modeling of Individual Red Blood Cell Dynamics Using Discrete Flow Composition and Adaptive Time-Stepping Strategies

In this article, we present a finite element method for studying the dynamic behavior of deformable vesicles, which mimic red blood cells, in a non-Newtonian Casson fluid. The fluid membrane, represented by an implicit level-set function, adheres to the Canham–Helfrich model and maintains surface inextensibility constraint through penalty. We propose a two-step time integration scheme that incorporates higher-order accuracy by using an asymmetric composition of discrete flow based on the second-order backward difference formula, followed by a projection onto the real axis. Our framework incorporates variable time steps generated by an appropriate adaptation criterion. We validate our model through numerical simulations against existing experimental and numerical results in the case of purely Newtonian flow. Furthermore, we provide preliminary results demonstrating the influence of the non-Newtonian fluid model on membrane regimes.

Computational fluid dynamics based Taguchi analysis on shear stress in microfluidic cerebrovascular channels.

The cerebrovascular blood vessels feed necessary agents such as oxygen, glucose, and so forth. to the brain which maintains the smooth functioning of the human body. However, the blood-brain barrier as a vascular border restricts the entry of drugs that can be necessary for the treatment of neurological disorders. The fluid shear stress in the cerebrovascular blood vessels may regulate the drug delivery in the interface between the cerebrovascular blood vessels and the brain. The intensity of influence by various factors that affects the shear stress in the cerebrovascular blood vessels is scarcely addressed in the present study. A hybrid approach of computational fluid dynamics and Taguchi analysis is proposed to evaluate the influence of various geometrical and operating factors on the shear stress in the microfluidic cerebrovascular channel. Furthermore, the non-Newtonian behavior of blood flow is considered to evaluate the shear stress in the microfluidic cerebrovascular channel. The Newtonian and six non-Newtonian fluids models of Carreau, Carreau-Yasuda, Casson, Cross, Ostwald-de Waele, and Herschel-Bulkley are numerically tested under various conditions of the flow rate, width, and height of the channel to find the viscosity influence on the shear stress. The Taguchi analysis consisting of range and variance analyses is applied to the L16 orthogonal array to evaluate the effect of various factors on shear stress in terms of influence order, range, F value, and percentage contribution. The parameters for the considered six non-Newtonian fluid models are proposed to accurately map the viscosity behavior with shear strain compared to the actual blood flow behavior. The Newtonian, Carreau, and Carreau-Yasuda non-Newtonian fluid models are found accurately with maximum errors between the experimental and numerical shear stress results as 2.17%, 1.30%, and 1.48%, respectively. The shear stress decreases with an increase in the width and height of the channel and a decrease in the viscosity for all flow rates. The porosity is evaluated as a highly influential factor followed by the flow rate, width, and height of the channel in decreasing order based on their effects on the shear stress. The modified shear stress equation is proposed with an accuracy of 0.96 by integrating the effect of porosity in addition to width, height, flow rate, and viscosity. The in-vitro microfluidic cerebrovascular model could be designed and manufactured based on the proposed results on influence order, F value, and percentage contribution of various factors in direction of achieving the in-vivo level shear stress.

Enhancement of heat mass transmission characteristics through a non-Newtonian nanofluid model due to a convectively heated stretched sheet which exposed to a magnetic field

This research is innovative in that it investigates the flow of a Maxwell nanofluid that exhibits non-Newtonian behavior over a horizontally stretching sheet, using a boundary layer medium and taking into account the Cattaneo-Christov model. Thermal radiation and the effects of fluctuating nanofluid conductivity with temperature on a stretched, linearly impermeable surface are also taken into account. The main topic of the research is the situation when the viscosity of the nanofluid changes with temperature. The group of differential equations that drives our proposed problem is highly nonlinear and is numerically solved by the shooting method. The results are given in accordance with graphs of a number of newly influential parameters against velocity, temperature, and concentration fields. Skin friction coefficient, Nusselt number, and Sherwood number, which are coupled to velocity, temperature, and concentration distributions recorded in tables, have been provided for a range of values of the regulating physical emergent factors. Some significant findings suggest that increasing the magnetic number, viscosity parameter, and Maxwell number results in decreased motion of the nanofluid, while concentration and temperature distribution increase. After completing our computations, we organized the findings and compared them to previous research. Our observation is that the proposed method's accuracy and reliability have been proven.

Heat transfer assessment for Au-blood nanofluid flow in Darcy-Forchheimer porous medium using induced magnetic field and Cattaneo-Christov model

Stagnation point flow defines the fluid motion near the stagnation point of a solid surface and has utilization in the process of polymer extrusion, electronic gadgets cooling, nuclear reactor, etc. Furthermore, the main theme of this work is to analyze the heat transfer characteristics of stagnation point flow of Casson nanofluid over stretching sheet using induced magnetic field and Cattaneo-Christov model. The Casson fluid is a non-Newtonian fluid model; and in the current work the working fluid consists of nanoparticles of Au (Gold) and blood (Casson fluid). In the existing model, temperature of the surface depends on the distance from the stagnation point. Therefore, Darcy-Forchheimer porous model is incorporated. The solution of coupled nonlinear PDEs is obtained by bvp4c. The heat transfer and flow characteristics of Au-blood based Casson nanofluid are discussed graphically. The dual behavior is observed in the profiles of induced magnetic field with increase in the value of reciprocal magnetic Prandtl number, however the velocity outlines of Au-blood nanofluid declined. A comparison is presented with previous article and is found to be in good agreement.

Towards an approximate solution of highly viscous electro-osmotic flows in inclined Channel: Applications in petroleum and gas engineering

Electro-osmotic flows (EoF) through an inclined channel are investigated in this article. Differential type non-Newtonian fluid model has been used to form highly viscous bi-phase fluid flows. Two different kinds of metallic particles are considered for disperse phase. The application of external electric fields and gravitational force are the main sources of multiphase flows under the magnetic environment. Nonlinear differential equations are formulated taking the stress tensor of fourth-grade fluid, Poisson equation, and Debye length approximation into account, respectively. An approximate solution is obtained for the nonlinear flow problems. Comparative analyses have also been performed with the previous investigations via tables and graphs and, were found to be in great agreement. A comprehensive parametric study is carried out, as well, which reveals that there is a definite difference between the momentum of the fluid phase and the particles phase. The contribution of the Helmholtz–Smoluchowski parameter in each phase is quite supportive. However, the effects of the transverse magnetic field and electro-osmotic parameter are in full coherence. Moreover, traditional multiphase flows can be derived for the limiting case. Finally, this theoretical study explicitly describes the applications in petroleum and gas engineering.

Association of blood viscosity and device-free days among hospitalized patients with COVID-19

BackgroundIncreased estimated whole blood viscosity (eWBV) predicts higher mortality in patients hospitalized for coronavirus disease 2019 (COVID-19). This study assesses whether eWBV is an early predictor of non-fatal outcomes among patients hospitalized for acute COVID-19 infection.MethodsThis retrospective cohort study included 9278 hospitalized COVID-19 patients diagnosed within 48 h of admission between February 27, 2020 to November 20, 2021 within the Mount Sinai Health System in New York City. Patients with missing values for major covariates, discharge information, and those who failed to meet the criteria for the non-Newtonian blood model were excluded. 5621 participants were included in the main analysis. Additional analyses were performed separately for 4352 participants who had measurements of white blood cell count, C-reactive protein and D-dimer. Participants were divided into quartiles based on estimated high-shear blood viscosity (eHSBV) and estimated low-shear blood viscosity (eLSBV). Blood viscosity was calculated using the Walburn–Schneck model. The primary outcome was evaluated as an ordinal scale indicating the number of days free of respiratory organ support through day 21, and those who died in-hospital were assigned a value of -1. Multivariate cumulative logistic regression was conducted to evaluate the association between quartiles of eWBV and events.ResultsAmong 5621 participants, 3459 (61.5%) were male with mean age of 63.2 (SD 17.1) years. The linear modeling yielded an adjusted odds ratio (aOR) of 0.68 (95% CI 0.59–0.79, p value < 0.001) per 1 centipoise increase in eHSBV.ConclusionsAmong hospitalized patients with COVID-19, elevated eHSBV and eLSBV at presentation were associated with an increased need for respiratory organ support at 21 days. These findings are highly relevant, as they demonstrate the utility of eWBV in identifying hospitalized patients with acute COVID-19 infection at increased risk for non-fatal outcomes in early stages of the disease.