non-Newtonian Blood Flow Research Articles

Peristaltic Flow of Jeffrey Fluid in an Inclined Porous Tube with Multi-Thrombosis

The fact that multiple thrombosis opposes blood flow and flow is rare in blood vessels is refined to a normal condition with catheter application. The inner surface of the circular blood arteries may not be smooth in the majority of diseased instances. Additionally, the small blood vessel peristalsis mechanism is formed. In this paper, we discuss a mathematical model for the flow of biological fluid (blood) in a circular tube with multi-thrombosis considered under peristaltic wave propagation. The blood flow in this tube is restricted due to the many thromboses present, and the flow is redesigned with the aid of a catheter. We model this non-Newtonian blood flow issue for Jeffrey fluid. In most pathological cases, the inner surface of the circular blood vessels may not be smooth. Further, the mechanism of the peristalsis is established for small blood vessels. Because of this biological phenomenon, the peristaltic movement of Jeffrey fluid in a porous annulus with slip is examined. Equations that govern energy and momentum are solved exactly, and graphical interpretation is made using mathematical software. Streamline graphs show the many thromboses that increase in height. The wall shear stress graphs show a sinusoidally advancing wave with peaks and dips of different amplitudes. This tube's unique crest and trough amplitude are caused by the presence of multiple thromboses. We obtained the impact of the pressure gradient on the permeability parameter (β). The pressure gradient falls as the permeability parameter rises.

Numerical simulation of non-Newtonian blood flow in a human arterial bifurcation model

Hemodynamic factors play a role in atherogenesis and the localization of atherosclerotic plaques. The human aorta and coronary arteries are susceptible to arterial disease, and there have been many studies of flows in models of these vessels. Atherosclerosis is a systemic disease occurring in specific sections of the cardiovascular tree such as the carotid and the coronary arteries. This paper aims to simulate the human arterial bifurcation and investigates some hemodynamic parameters as blood propagates from the aortic artery toward the carotid artery. We analyze the velocity, static pressure, shear stress. The simulation results showed disturbed flow patterns, such as flow separation and stagnation, as well as abnormal hemodynamic parameters (HPs) distributions including the low and high wall shear stress (WSS) and oscillation of wall shear stress. Based on our simulating characteristic results, the CFD tools can not only monitor the hemodynamic parameters obviously, but also help to analyze the diagnostic for the treatment of vascular diseases. CFD can be an effective technology for the examination and treatment of patients with failure of blood supply of the head and brain.

The influences of artery radii and stenosis severity on the thermal behavior of blood by employing Sisko and Lumen models: Numerical study

Artery stenosis occurs when blood vessels do not supply enough blood and oxygen due to blockage by a fatty mass called plaque. In this work, the influence of stenosis on the Nusselt number (Nu) for non-Newtonian blood flow is studied by the FVM method and using fluent software. Also, the artery is simulated based on the Lumen model. In this research, at first, it is assumed that stenosis severity increases as much as 20 %, 30 %, and 40 % of the internal cross-section area of the artery respectively while the radius is constant, then the stenosis severity is fixed at 40 %, and only radius of artery increases from 0.002 m to 0.0025, 0.0030, and 0.0035 m. The artery wall is affected by constant heat flux and Nusselt numbers in every stage as a significant parameter in each flow are calculated. It should be mentioned that the Nusselt numbers are achieved both in the direction of flow and perpendicular to one. The results show that an increase of stenosis severity from 20 % to 40 % and a decrease of the artery radius between 0.002 and 0.0035 m leads to Nusselt number enhancement due to acceleration of blood flow and increase of heat transfer while the maximum values of Nusselt number remain no change approximately. Therefore, influences of stenosis size on the thermal behavior of blood in the artery are not noticeable, and thermal risks are ignorable.

Non-Newtonian blood flow across stenosed elliptical artery: Case study of nanoparticles for brain disabilities with fuzzy logic

This analysis aimed to explore the blood-based non-Newtonian hybrid nanofluid flow in elliptical stenosed artery with single- and multi-walled carbon nanotubes as nanoparticles. The Carreau fluid model is incorporated to assess the non-Newtonian rheology of blood-based nanofluid for mild stenosis. In particular, the carotid artery is responsible for delivering blood to the brain. If normal blood circulation is disrupted or in the case of severe stenosis, blockage of the carotid artery can lead to the development of brain disability or stroke, which in turn can lead to death. The idealized mathematical equation is transformed into a nondimensional form and solved analytically via the perturbation method through a novel polynomial technique. These analytical solutions are explored and explained graphically. The system’s disorder and variability are assessed by completing an entropy production analysis. The disruption in blood flow due to the presence of nanoparticles causes uncertainty in the flow nature. This uncertainty is dealt with by fuzzy analysis of temperature distribution by accounting for the nanoparticle volume fractions as triangular fuzzy numbers. It is noticed that stenosis shapes and height greatly impact the flow characteristics. The nanoparticles’ percentage in fluid affected the temperature profile. The non-Newtonian characteristics of blood are found to be more dominant along the minor axis, and an effectively higher disorder is produced in this direction. It is observed that the temperature of nanofluid emerged as a triangular fuzzy number of symmetric shape.

A comparative study of Newtonian and non-Newtonian blood flow through Bi-Leaflet Mechanical Heart Valve

The present study examines flow through Bi-Leaflet Mechanical Heart Valves (BMHV) at physiological conditions considering both Newtonian and non-Newtonian fluid models for blood rheology. It is well known that the non-Newtonian effects of blood are pronounced in small diameter arteries. Most of the earlier works on Mechanical Heart Valves (MHV) have considered blood as a Newtonian fluid as the flow involves large-diameter artery such as the aorta. In this work, we have reported the predicted parameters, such as leaflet kinematics, vortex structures, wall shear stress, and blood damage index for both blood models. It is found that the leaflet attributes smaller asynchronous motion in the case of non-Newtonian Carreau fluid model with slightly reduced angular velocity compared to the Newtonian assumption. Predictions on the blood damage index suggest a 21% higher damage while using non-Newtonian model than Newtonian model, which may be attributed to higher levels of mechanical stress within the fluid. However, vortex structures, time-averaged wall shear stress (TAWSS), and oscillatory shear index (OSI) are found to be similar in predictions using both the fluid models. We have used an in-house sharp interface immersed boundary method with fluid–structure interaction to simulate the coupled action of moving valves and pulsatile blood flow. Our findings suggest that the general consensus of using Newtonian model in large arteries may not be appropriate for prediction of leaflet kinematics and blood damage index in Mechanical heart valves.

Hemodynamic coupling between a primary atherosclerotic plaque and subsequent secondary lesions

Atherosclerosis is one of the most common diseases of the arterial tree, especially in the coronary arteries. Stenoses exceeding 50% area reduction are shown to alternate the downstream coronary flow, and hemodynamics will lead to further atherogenesis. Clinical evidence also confirms that vascular stenoses are not stagnant since they are usually associated with downstream lesions. In this study, it is hypothesized that the formation of secondary plaques, or aneurysms downstream of a primary stenosis, compensates for the abnormal ranges of hemodynamic forces caused by the primary stenosis. An experimental setup captured the hemodynamics of non-Newtonian blood flow in three-dimensional (3D) printed phantoms of coronary arteries with various sequences of lesions. Then, based on the collected data, in silico models of these lesions were simulated using computational fluid dynamics. For the proposed cases, time-averaged wall shear stress, velocity profile, oscillatory shear index, and relative residence time were extracted at the plaque side and the plaque front walls and compared to the reference model with only the primary plaque. The secondary plaque postulated the abnormal hemodynamic conditions to its downstream, which implies endothelial activation and onset of further pathologic events. However, the secondary aneurysm restored flow conditions to normal after its distal shoulder, preventing more damage to the endothelium. Examined angiograms of patients with developed atherosclerotic lesions unveiled that a sequence of plaques is formed over time, and most interestingly, the series stopped after the formation of an aneurysm.

Modeling analysis of pulsatile non-Newtonian blood flow in a renal bifurcated artery with stenosis

A transient transport flow model is adopted in a renal bifurcated artery with different stenosis cases to examine the flow phenomena when the non-Newtonian blood flow regime within the three-dimensional space domain is chosen as a pulsatile nature. The nonlinear governing equations are solved using the Finite Element Method with suitable initial-boundary conditions. During numerical computation, distinct hemodynamic parameters including Wall shear stress, Reynolds number, power law index are evaluated based on different stenosis severities (0%, 25%, and 50%) and stenosis lengths (0mm, 0.5mm, and 1mm). For 0%, 25%, and 50% stenosis, the approximate values of velocity and pressure profiles are estimated at t = 5s at various positions, and achieved the highest velocities that were around 0.07m/s, 0.08m/s, and 0.13m/s respectively. The unsteady response of the stress due to stenosis-induced shear on the outside wall is described as a result of stenosis at t = 0.1s, 0.2s, 5s. The flow is severely restricted by constriction, which increases wall movement and produces stress, depending on the amount of stenosis. As pulsatile flow time increases due to the presence of stenosis, the wall shear stress decreases gradually. The impact of Reynolds numbers on pressure profiles and velocity profiles are displayed for Re = 100, 300, 500, and 700, and found that both velocity and pressure outlines increase significantly. In order to identify the flow phenomena, the influences of the power law index for n = 0.1, 0.3568, 0.5 are presented on the velocity and pressure profiles. Shear-thinning flow occurs for 0<n<1, pseudoplastic flow occurs for n = 0.1 and Bingham plastic flow occurs for n = 0.5. The modeling investigations of blood flow via arteries could assist in the diagnosis and treatment of arterial illnesses; as well as expand the knowledge about cardiovascular physiology and lead the development of revolutionary medical interventions to enhance patient treatment outcomes.

Thermal Analysis of a Casson Boundary Layer Flow over a Penetrable Stretching Porous Wedge

This work aims to analyze the Casson thermal boundary layer flow over an expanding wedge in a porous medium with convective boundary conditions and ohmic heating. Moreover, the effects of porosity and viscous dissipation are studied in detail and included in the analysis. The importance of this study is due to its applications in biomedical engineering where the analysis of behavior of non-Newtonian blood flow in arteries and veins is desired. Within the context of blood flow, it is also applicable to many other fields, for instance, radiative therapy, MHD generators, soil machines, melt-spinning, and insulation processes. The modeled problem is a set of PDEs, which is nondimensionalized to derive a nonlinear boundary value problem (BVP). The obtained BVP is solved using the shooting technique, endowed with the order four Runge-Kutta and Newton methods. The impact of different parameters on the momentum and temperature fields is investigated along with two important parameters of physical significance, i.e., the Nusselt number and the surface drag force. Results are validated, and an excellent agreement is seen for the parameters of interest using MATLAB built-in function bvp4c. A significant finding is that by increasing the Casson liquid parameter, the velocity decreases as the wedge expands quicker than the free stream velocity at R=2. However, the velocity increases for the case when R=0.1. A decrease in the Darcy number increases the temperature profile. Furthermore, the convective parameter accelerated the heat transmission rate, and a rise in the Prandtl number thickens the thermal boundary layer. The findings of this investigation contribute to problems in fluid dynamics and heat transfer that involve studying the behavior of a non-Newtonian fluid with Casson rheological properties near a solid porous wedge surface.

Entropy-based analysis of hemodynamics in elliptical arterial flows with non-Newtonian Rabinowitsch fluid

This research concerns examining the non-Newtonian blood flow behavior through an artery of elliptic cross-section, affected by several stenoses. The Rabinowitsch fluid model is used to investigate the non-Newtonian behavior of the blood for uniform and nonuniform shapes of stenosis. The mathematical equations have been converted into a dimensionless form, and their nonlinearity is reduced by applying the assumptions of mild stenosis. The resulting differential equations are solved by using analytical techniques. A new polynomial of degree eight is introduced to complete the solutions of mathematical equations. The entropy generation is studied mathematically to analyze the irreversibility effects. The detailed graphical examination delineates the physical aspects of mathematical results. The flow velocity is higher for uniform shape than for nonuniform stenosis. The rising percentage of stenosis significantly enhances the flow velocity of the stenotic region. The entropy is enormous near the stenotic wall and has small values near the centerline, which assures the smooth flow in this region. Further, the streamlines are plotted to find the position of stenosis and assess the flow nature for the growing height of stenosis and rising flow rate.

Pulsatile pressure-driven non-Newtonian blood flow through a porous stenotic artery: A computational analysis

Blood flow through a narrowed artery, such as those caused by plaque buildup, can lead to various cardiovascular diseases. Therefore, studying this phenomenon is essential for developing better treatments and understanding the underlying mechanisms. In this study, a mathematical model is developed to simulate blood flow through stenotic arteries with porous walls. The familiar Navier-Stokes equations are executed to simulate flow, whereas the Carreau fluid model is employed to quantify blood rheology. This model illustrates both Newtonian and non-Newtonian characteristics depending on the shear rate. Other than that, the blood vessel is assumed to have a moderate level of stenosis with porous saturated walls. The solution of the governed partial differential equations is carried out using a finite difference scheme. Our research addresses the impacts of permeability and rheological parameters, stenosis size, Brinkman number, and Prandtl number on blood velocity, flow rate, resistance to flow, wall shear stress, and temperature distribution. The findings demonstrate that while flow resistance reduces, the velocity, shear stress, and flow rate increase with high permeability values. Conversely, as the stenosis amplitude increases, the magnitude of wall shear stresses, velocity, and flow rates decrease. In addition, blood rheology also has the potential to transfigure the aforementioned factors. We also found that the temperature distribution increases with the Brinkman number, stenosis size, permeability, and power law exponent. It drives down, however, by raising the values of Weissenberg number and Prandtl number. Collectively, our findings contribute to a better understanding of the complicated phenomena of blood flow in stenotic vessels with porous saturated walls. The findings of this study may be valuable in establishing improved therapies for cardiovascular disorders and formulating more precise mathematical models to forecast blood flow in vivo.

Pulsatile flow of EMHD non-Newtonian nano-blood through an inclined tapered porous artery with combination of stenosis and aneurysm under body acceleration and slip effects

Research on blood flow in diseased arteries has become a priority in recent years. Stenosis/aneurysm is the most common arterial diseases. This work investigates the mixed effect of electric and magnetic fields on the unsteady, two-dimensional, laminar, non-Newtonian pulsatile flow of blood in an axisymmetrically inclined tapered porous artery with stenosis and aneurysm containing gold nanoparticles, subjected to body acceleration and slip effect. Thermal radiation and heat sources are also included. To immobilize the effect of the vessel wall, we use a radial coordinate transformation. The nonlinear partial differential equations governing the present problem, together with the prescribed boundary conditions, are solved using an explicit finite-difference scheme. The current analysis could help to understand the improvement in mass distribution and heat transfer in diseased blood vessels, which might be useful for drug delivery in the therapy of stenosis and aneurysm.

Hemodynamic Study of Cerebral Arteriovenous Malformation: Newtonian and Non-Newtonian Blood Flow

ObjectiveArteriovenous malformation is a disease of the vascular system that occurs mainly in the cerebral arteries and spine. Numerical simulation as a powerful method is used to investigate the Cerebral Arteriovenous Malformation hemodynamic after occlusion of the abnormality step by step by embolization. MethodsThe CT Angiographic imaging data of two patients are used and a geometric model is extracted by the Mimics software. Numerical simulation of blood flow is performed in both Newtonian and non-Newtonian models. The Navier–Stokes, and continuity governing equations are solved by finite element method using the COMSOL Multiphysics software (the commercial computational fluid dynamics (CFD) simulation software). To validate the numerical results, the real data on blood flow rate in the feeding artery and draining veins are used, as well as angiographic images at different times. ResultsRegarding the comparison of pressure contours for different occlusions of 0, 30, 50, and 90%, by increasing the amount of occlusion in the nidus, there is an increase in the blood pressure. Regarding the comparison of the blood flow velocity in the feeding artery, draining veins, and inside the AVM nidus for Newtonian and non-Newtonian models, there is a significant difference between these two simulations in vessels with smaller dimensions (such as vessels inside the nidus). ConclusionBy increasing the amount of nidus occlusion, the blood pressure is increased, so the blood supply process is better. According to a significant difference between the Newtonian and non-Newtonian simulations in vessels with smaller dimensions (such as vessels inside the nidus), therefore, non-Newtonian simulation should be done for different occlusions of 30, 50, and 90%.

Computational analysis of patient-specific pulsatile blood flow: The influence of non-Newtonian models on wall shear stress assessment

Blood is a sophisticated biological fluid with components like erythrocytes that give it non-Newtonian behavior. Hemodynamic factors such as velocity magnitude, pressure, and wall shear stress descriptors are the most important factors in the development of atherosclerosis. The wall shear stress descriptors are regulated not only by flow geometry but also by blood rheological properties. In the current study, we carried out a numerical analysis of the non-Newtonian pulsatile blood flow while taking into account a patient-specific geometry and transient boundary conditions. Non-Newtonian blood flow is modeled using the four non-Newtonian models: the power-law model, the Carreau model, the Casson model, and the Quemada model, and compared with the Newtonian model. Streamline analysis vividly illustrates velocity patterns, revealing the presence of recirculation zones near sinus regions. The study suggests the significance of selecting appropriate viscosity models for accurate assessments, particularly in regions with low time-average wall shear stress values, such as those associated with atherosclerotic plaques. The differences in the time-averaged wall shear stress between the four non-Newtonian models were found to be the highest in the Quemada model. The study concluded that the non-Newtonian model is required when the focus is on the low-time-averaged wall shear stress area.

CFD Analysis of Pulsatile Non-Newtonian Blood Flow in a Multi-Staged Stenosed Bifurcated Carotid Artery

Accumulation of plaque on the arterial walls leads to a cardiovascular condition known as Atherosclerosis. This leads to lumen stenosis, and when it occurs in the carotid artery, it can impede the blood-flow to the face, brain, and neck, potentially leading to a stroke. The aim of this paper is to provide a comprehensive study of the carotid artery under multiple stenosed conditions using Computational Fluid Dynamics. In this study, blood has been considered to be a non-Newtonian fluid exhibiting pulsatile flow based upon the Carreau model and a two-dimensional bifurcated human carotid artery has been modelled. The Navier-Stokes equations-based FVM (Finite Volume Method) is used to analyze the flow inside the artery, while RANS k-ω SST turbulence model has been applied in the analysis of parameters of blood under stenosed conditions. Four models based on different stages of stenosis (0%; 25%; 50% and 75%) have been developed with simulations run on Ansys to find the effects under stenosis. For all the simulations, 65:35 flow division has been used, indicating that 65% of the total blood flows through the Internal Carotid Artery and 35% flows through the External Carotid Artery. Velocity and pressure contour, velocity distribution on the modelled plane and wall shear stress on arterial walls are the primary parameters studied at varying timescales of a cardiac cycle. As the stenosis stage increases, the flow separation can be predicted with higher accuracy. With the help of these parameters, one can build and design better treatment choices, such as designing of stents with different materials or adding of Ag-Au (Silver - Gold) nanoparticles in the blood to change the hemodynamics.

Numerical simulation of pulsatile blood flow through eccentric double stenosed carotid artery

Purpose This study aims to perform three-dimensional numerical computations for blood flow through a double stenosed carotid artery. Pulsatile flow with Womersley number (Wo) of 4.65 and Reynolds number (Re) of 425, based on the diameter of normal artery and average velocity of inlet pulse, was considered. Design/methodology/approach Finite volume method based ANSYS Fluent 20.1 was used for solving the governing equations of three-dimensional, laminar, incompressible and non-Newtonian blood flow. A high-quality grid with sufficient refinement was generated using ICEM CFD 20.1. The time-averaged flow field was captured to investigate the effect of severity and eccentricity on the lumen flow characteristics. Findings The results show that an increase in interspacing between blockages brings shear layer instability within the region between two blockages. The velocity profile and wall shear stress distribution are found to be majorly influenced by eccentricity. On the other hand, their peak magnitude is found to be primarily influenced by severity. Results have also demonstrated that the presence of eccentricity in stenosis would assist in flow development. Originality/value Variation in severity and interspacing was considered with a provision of eccentricity equal to 10% of diameter. Eccentricity refers to the offset between the centreline of stenosis and the centreline of normal artery. For the two blockages, severity values of 40% and 60% based on diameter reduction were permuted, giving rise to four combinations. For each combination, three values of interspacing in the multiples of normal artery diameter (D), viz. 4D, 6D and 8D were considered.

The emerging concept of glycocalyx damage as the trigger of heart failure onset and progression

The suppression of adrenergic and renin-angiotensin-aldosterone system (RAAS) activity, exaggerated due to hypoperfusion-related hypoxia and/or sodium retention, is crucial for drugs’ efficacy in heart failure (HF). Both, insufficient oxygenation and excess sodium impair the glycocalyx-dependent microcroperfusion and peripheral metabolism, therefore enhancing the adrenergic and RAAS activity. The local renal and pulmonary RAAS activity and hypoxia increase sodium retention. Interstitial sodium accumulation activates interstitial inflammation and coagulation disorders that further diminish glycocalyx-supported microperfusion and peripheral metabolism. The main trigger of glycocalyx damage in reduced ejection fraction (EF) HF is hypoxia; whereas, in HF preserved EF sodium retention prevails; both stimulate left ventricular (LV) cardiac output (CO), however, impair microperfusion and metabolic heat production. Infrared-dependent, surface-induced flow (SIF) and diamagnetic properties of oxygenated haemoglobin; both improve non-Newtonian blood flow. Therefore, the temperature-driven SIF augments the deoxygenated erythrocytes' flow, while the pulmonary oxygenation of haemoglobin, by diamagnetic properties, enables frictionless erythrocytes’ flow in the oxygenated blood compartments complementing the cardiac function in HF.

Influence of parent vessel feature on the risk of internal carotid artery aneurysm rupture via computational method

In this study, the role of sac section area and parent vessel diameter on the hemodynamic feature of the blood flow in selected internal carotid artery (ICA) aneurysms is comprehensively investigated. The changes of wall shear stress, pressure, and oscillatory shear index (OSI) of blood stream on the vessel for various aneurysms with coiling treatment. To attain hemodynamic factors, computational technique is used for the modeling of non-Newtonian transient blood flow inside the three different ICA aneurysms. Three different saccular models with various Parent vessel mean Diameter is investigated in this study. The achieved outcomes show that increasing the diameter of the parent vessel directly decreases the OSI value on the sac surface. In addition, the mean wall shear stress decreases with the increase of the parent vessel diameter.

Numerical analysis of the behavior of two-phase blood flow in locally magnetized vessel

The main purpose of this study is to analyze the behavior of non-Newtonian blood flow under localized magnetic field. To that end, we consider a 2-dimensional and two-phase fully-developed biomagnetic fluid model in a rectangular artery. The blood flow model considers the ferrohydrodynamic (FHD) and magnetohydrodynamics (MHD) parameters, which differ from the traditional model based upon Navier-Stokes equations. An external user-defined (UDF) source code was used to define fully-developed flow, viscosity, FHD and MHD properties in magnetic and non-magnetic regions. The numerical outcomes are evaluated in consideration of their potential uses in the field of magneto-hemorheology. All the physical parameters used to interpret the findings are consistent with the pathological conditions. The solutions are displayed as velocity, stream function, temperature contours. The study reveals that blood flow can be regulated by modifying the magnetic field strength, artery diameter, and concentration of red blood cells within the artery. In particular, it could be useful for surgical treatments of cancer and dengue diseases in the extraction of affected red blood cells from the bloodstream.

MHD blood flow effects of Casson fluid with Caputo-Fabrizio fractional derivatives through an inclined blood vessels with thermal radiation

This study investigates a fractional-order time derivative model of non-Newtonian magnetic blood flow in the presence of thermal radiation and body acceleration through an inclined artery. The blood flow is formulated using the Casson fluid model under the control of a uniformly distributed magnetic field and an oscillating pressure gradient. Caputo-Fabrizio's fractional derivative mathematical model was used, along with Laplace transform and the finite Hankel transform technique. Analytical expressions were obtained for the velocity of blood flow, magnetic particle distribution, and temperature profile. These distributions are presented graphically using Mathcad software. The results show that the velocity increases with the time, Reynolds number and Casson fluid parameters, and diminishes when Hartmann number increases. Moreover, fractional parameters, radiation values, and metabolic heat source play an essential role in controlling the blood temperature. More precisely, these results are beneficial for the diagnosis and treatment of certain medical issues.

Investigation of the Effects of an Inferior Vena Cava Filter and Captured Clot Size on the Hemodynamic Parameters in Non-Newtonian Turbulent Pulsatile Blood Flow

In this computational fluid dynamics (CFD)-based study, the effects of inferior vena cava (IVC) filter implantation on the risk of IVC thrombosis have been investigated using different hemodynamic parameters, including time-averaged wall shear stress (TAWSS), the oscillating shear index (OSI), and the relative residence time (RRT). The boundary conditions in this study have been based on physiological pulses. Additionally, the k–ω model and the Carreau model have been chosen to represent the turbulent flow regime and non-Newtonian blood, respectively. For this purpose, three blood clots with the largest cross-sectional diameters of 30%, 50%, and 70% of the filter diameter have been used. Capturing a small clot in the filter has the minimum effect on the hemodynamic parameters, while by increasing the size of the captured clot, OSI and RRT parameters increase in areas downstream of the filter on the wall. The presence of a filter and clot increases the risk of thrombosis. In the case of capturing large clots, there is the possibility of damage to endothelial cells or platelet activation. Captured clots lead to the formation of plaque and thrombus on the IVC wall. However, the possibility of thrombus growth on its surface is not negligible, particularly if larger clots are trapped in the filter.