In this work attempt has been made to assess the effect of few pesticides (namely Metacid-50 or M, Kelthane (or K) and Dithane M-45 (or D) and their mixture on changes in water, lipid and non-lipid fractions (major part protein, very less carbohydrate and minerals) in a fresh water teleostean fish, Channa gachua (HAM) in their body muscles at different concentrations during different exposure times. In control group the water, lipid content and non-lipid fractions were 76.559%, 0.774% and 22.667% respectively. Increased water content in muscles were obtained after 24hrs. and 48hrs. exposure of individual or mixed pesticides condition but the lipid content decreased in all the animals. Statistical relationship between concentration of pesticides Vs muscles, water and lipid have also been established.