In this paper, the problem of adaptive neural network prescribed performance tracking control for a class of non-strict feedback time-delay systems constrained by full-state is studied. Radial basis function (RBF) neural networks (NNs) are integrated into the backstepping medium to deal with the uncertain functions and the barrier Lyapunov function (BLF) technique ensures that the state of the system does not exceed its limits. Subsequently, integrated with the Lyapunov–Krasovskii functional, the proposed control scheme makes the tracking errors converge to the preset region while the state constraint is not violated. Finally, the effectiveness of the scheme is supported by two simulation experiments.