The “Substitute Frame” (SF) model, which is a simplified MDOF system consisting of a one-bay multistory frame, has recently been introduced by the authors to predict the static and dynamic response of RC building frames, especially in terms of Interstory Drift Ratio (IDR) and plastic hinge rotation. It is known that incremental dynamic analysis (IDA) is one of the most accurate nonlinear seismic analyses that is of course a time-consuming method, having a high computational cost. Hence, this paper aims to focus on the accuracy and speed of the Substitute Frame (SF) as a simplified frame model in performing IDA, fragility analysis, and other probabilistic analyses. If the desired result is achieved, this can be promising to perform extensive probabilistic analysis efficiently. To this end, three 8-, 12-, and 20-story benchmark RC moment frames were selected and the corresponding simplified SF models were generated. To accurately perform the required analyses, the OpenSEES software by implementing modified Ibarra-Medina-Krawinkler springs with deteriorating peak-oriented behavior was used to apply Nonlinear Time-History Analysis (NTHA) using the Hunt-Fill algorithm for IDA analyses. The results showed that the SF model can be reliably applied to perform IDA analyses and developing fragility curves and it is computationally efficient and robust. The selected OpenSEES example files for the present study, are shared through the link “https://web.nit.ac.ir/~h.hamidi/software_data.htm”.