The nanofluids have well-known implications in pharmaceutical industries, microelectronics, heat exchangers, engine cooling, hybrid-powered engines, thermal management of vehicles, refrigerator, machining, chillers, grinding, and in boiler fuel to reduce the gas temperature. Due to such dominant implications of nanofluids, the boundary layer Reiner-Rivlin nanomaterial flow over chemically reactive stretched sheet is considered. Radiation term is incorporated in the energy equation for heat transportation analysis. Newtonian thermal and solutal conditions are implemented at the boundaries of the surface. Similarity variables are utilized for the conversion of nonlinear partial differential equations into the system of one independent variable equations. The resulted system of equations is calculated analytically with the help of homotopy analysis method. Convergence of the calculated results is verified through plots and numeric benchmark. The results of various pertinent parameters on quantities of physical importance are drawn and discussed in detail. Results revealed that the incremented cross viscous constraint resulted higher velocity and lower temperature profiles. An augmentation in radiative constraint gives rise to temperature field. Concentration and temperature have reverse trends against the rising Brownian motion constraint values.