We present a theory for plasmonic crystal instability in a semiconductor field-effect transistor with a dual grating gate array, designed with strong asymmetry in the elementary cell of this “crystal”. We demonstrate that, under the action of a dc current bias, the Bloch plasma waves in the plasmonic crystal formed in this transistor develop the Dyakonov–Shur instability. By calculating the energy spectrum and instability increments/decrements—which govern the growth/decay of excitations within the plasmonic crystal—we analyze the dependence of the latter on the electron drift velocity and the extent of the structural asymmetry. In contrast with the corresponding problem for gate arrays with symmetric unit cells, the presence of finite plasma instability increments across the entire Brillouin zone is established. This important difference points to the possibility of exciting sustained, radiating, non-linear electron plasma oscillations in the instability endpoint of the asymmetric array. These structures should be readily implementable in common semiconductor heterostructures, using standard nanofabrication techniques, enabling operation at room temperature. Long-range coherence of the unstable plasma oscillations, generated in the elementary cells of the crystal, should dramatically increase the radiated THz electromagnetic power, making this approach a promising pathway to the generation of THz signals.