Numerical studies of flow in square enclosures attain great interest due to their wide applications in engineering, such as in the meteorology, navigation, mechanology and mining, etc. In this paper, the solutions are obtained to the square lid driven cavity describing classical mixed convection in the presence of an inclined magnetic field, chemical radiation and heat absorption/generation. The problem is mathematically reduced into Navier-Stokes equations. The Coiflet wavelet homotopy approach, a newly suggested computational technique, is then used to solve these nonlinear partial differential equations with their non-homogeneous boundary conditions. The numerical solutions for streamlines, isotherms, iso-concentrations contours, Nusselt number are carefully determined. The solutions so obtained are analyzed through various plots to demonstrate the effects of several physical parameters such as Reynolds numbers (Re), Richardson number (Ri), Grashof number (Gr), Hartman number (Ha), thermal radiation parameter (NR), chemical reaction coefficient (K), heat generation/absorption coefficient (Qh), the angle of inclination of magnetic field (γ), slipping parameter (λ) and Schmidt number (Sc) and their physical insights are also reported. Rigid comparison of with previous studies shows excellent computational effectiveness of newly proposed method. Additionally, according to the results, our recently proposed approach has superior characteristics and strong nonlinear processing capabilities, which render it more appropriate than the Coiflet wavelet analysis method and the traditional homotopy analysis method for tackling complex nonlinear problems.