Non-Hodgkin's Lymphoma Presenting Research Articles

HL-287: An Unusual Presentation of Discordant Classical Hodgkin and Non-Hodgkin Lymphoma in a Young Adult

Introduction Discordant lymphoma is the condition in which two subtypes of lymphoma occur synchronously in different anatomical sites. The objective is to highlight this exceptionally rare combination in order to prevent inaccurate diagnosis. Case Presentation A 20-year-old female presented with typical signs of diffuse supraclavicular and mediastinal lymph node enlargement. Based on the characteristic histological appearance of lymph nodes, she was diagnosed with classical mixed cellularity Hodgkin Lymphoma. Treatment was initiated with ABVD (adriamycin, bleomycin, vinblastine, dacarbazine) chemotherapy. Following four cycles of therapy, the patient underwent a PET scan that revealed partial remission with persistence of mediastinal lymph nodes. Two additional cycles of ABVD were initiated, followed by a repeat PET scan that revealed new anterior and mediastinal lymph nodes with a necrotic center. Radiotherapy was done with a dose of 36 Gy in 20 fractions. Three months later following therapy, the patient underwent a PET scan that showed new onset sub-diaphragmatic lymph nodes with necrotic centers, although it showed a major decrease in the mediastinal lymph nodes previously described. A biopsy was performed on the new appearing nodes and was in favour of diffuse large B cell lymphoma, most likely of non-germinal center cell of origin, and was expressing CD30. Following this discovery, additional cycles of R-DHAP (rituximab, dexamethasone, high-dose cytarabine, and cisplatin) were administered, resulting in a significant decrease in sub-diaphragmatic lymph nodes. Conclusion Even if strict guidelines are followed, we must remain aware that several types of lymphoma can coexist simultaneously, and discordant lymphoma should be considered, especially when new lymph nodes appear despite adequate therapy, and a biopsy is always recommended. Identifying this rare entity can offer a survival benefit.

Rare forms of non-Hodgkin lymphomas: experience in treatment for primary bone lymphomas

Primary bone lymphoma is a rare presentation of non-Hodgkin lymphoma. It accounts for a maximum of 1–2% of all non-Hodgkin lymphomas in adults. Primary bone lymphoma is diagnosed in focal lesions of one or more bones; soft tissue and regional lymph nodes may be involved too. The exclusion criteria are only bone marrow damage and involvement of distant lymph nodes. The first symptoms include intractable bone pain often accompanied by local edema, the formation of a tumor mass in the affected area; B symptoms occasionally join. Local lesions of long tubular bones in the diaphysis and metadiaphysis regions are more common (80%), while multifocal lesions are less frequent (20%). Diagnosis of lesions of the bone tissue in its primary and secondary involvement is based on the use of all available research methods (radiography; computed, magnetic resonance and positron emission tomography). Differential diagnosis requires an immunohistochemical study with determination of the expression of total leukocyte antigen, B-cell and T-cell markers, and clonality in one of immunoglobulin light chains κ or λ, bcl 2 and bcl 6, ALK, proliferative activity of Ki-67. Evaluation of the effectiveness of various treatments for primary bone lymphoma is complicated by a small number of observations and the absence of a uniform treatment strategy. CHOP-like chemotherapy cycles are often used as first-line therapy. Personalized therapy involves immunochemotherapy, radiation therapy and surgical treatment — endoprosthetics.

Varied Presentations of Non-Hodgkin Lymphoma in Head and Neck Region

Introduction
 Majority of lymphomas involving the head and neck are Non-Hodgkin lymphoma (NHL). Most of them present as cervical lymphadenopathy. The objectives of this study are to present the problems encountered in the diagnosis of extra-nodal NHL in head and neck region and show the importance of thorough clinical examination and proper investigation.
 Materials and Methods
 A prospective study was done in the department of ENT in a tertiary care hospital of West Bengal from July 2015 to June 2018. Patients diagnosed as NHL on the basis of histopathology and immunohistochemistry were included in this study. Patients who were lost in follow up were excluded from the study. Patients were treated with chemotherapy and radiotherapy by Oncologist. All patients were followed up routinely both by Otorhinolaryngologist and Oncologist. 
 Results
 There were 26 male and 11 female patients in this study. Patients were between 22 years to 76 years of age with highest incidence in 6th decade of life. Patients presented with only cervical lymphadenopathy; asymmetrical tonsillar enlargement with cervical lymphadenopathy; unilateral tonsillar enlargement only; huge inta-oral mass with stridor; parotid gland swelling; thyroid swelling with multiple cervical lymphadenopathy; epistaxis, palatal ulcer and cheek swelling; severe trismus with inconspicuous retro-mandibular mass. Majority of patients did well with chemoradiotherapy. Two patients succumbed to death, one with huge intra-oral NHL and another with nasal T/NK-cell lymphoma. 
 Conclusion
 Good knowledge of the clinical characteristics of extra-nodal NHL and the methods to establish the diagnosis are essential for a correct and timely therapy of the disease.

Isolated Medical Rectus Palsy as an Initial Presentation of Non Hodgkin Lymphoma

Isolated Medical Rectus Palsy as an Initial Presentation of Non Hodgkin Lymphoma

Non-Hodgkin Lymphoma Presenting as Tonsillitis

Non-Hodgkin Lymphoma Presenting as Tonsillitis

An unusual presentation of non-hodgkin's lymphoma

An unusual presentation of non-hodgkin's lymphoma

A case report on concurrent presentation of non-Hodgkin lymphoma and multiple myeloma

Background: The concurrent presentation of non-Hodgkin lymphoma and multiple myeloma is a very rare condition and only few cases have been reported. Case Presentation: In this case report, we discuss a patient who presented with abdominal pain, weight loss, and melena. After the patient’s admission, several examinations were conducted. Microscopic findings in pathological studies and immunohistochemistry staining studies revealed a malignant non-Hodgkin B-cell lymphoma. A monoclonal free light chain protein was documented in the urine protein electrophoresis. Serum protein electrophoresis was reported to be normal. Bone marrow biopsy demonstrated cellularity plasma cell aggregations as multiple myeloma. Small bowel segmental resection surgery was the treatment plan. To prevent the relapse of chemotherapy, rituximab in combination with cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy was tolerated by the patient. Finally, melena did not last after the resection and hemoglobin returned to its normal range. Conclusion: In conclusion, this case report suggests that both multiple myeloma and non-Hodgkin’s lymphoma are hematopoietic malignancies which originate from B-cell lymphocytes. To understand, properly manage, and treat this rare condition, multiple studies are required, and this can be achieved by comparing similar cases.

Clinicoepidemiological profile of extranodal lymphoma: The experience of a tertiary care center in India

Introduction: Lymphoma is a neoplastic proliferation of lymphoid cells at various stages of differentiation and affects lymph nodes, with infiltration into the bone marrow, spleen, and thymus, which form the primary lymphatic organs. Extranodal lymphoma, by definition, involves sites other than lymph nodes, spleen, thymus, and the pharyngeal lymphatic ring. Extranodal involvement is less common with Hodgkin lymphoma (HL) than with non-Hodgkin lymphoma (NHL). Materials and Methods: A single-center retrospective observational study was conducted over the period of 2017–2019. Age, gender, histologic type, location, type of clinical presentation, histologic diagnosis, and presence of specific symptoms were recorded, as were the specialty of the physician initially consulted and of the physician taking the diagnostic sample. Results: Twenty-seven cases of extranodal lymphoma were diagnosed: 12 (44.4%) were male and 15 (56.6%) were female patients. The median age for males was 49.6 years and for females was 45.7 years. In this study, we had varied presentations of the lymphoma with involvement of various structures. We had few patients with very rare site of involvement like an elderly female patient presented with firm swelling over the right forearm which on excision turned out to myeloid sarcoma. Similarly, an elderly woman had presented with pyrexia of unknown origin that was later diagnosed as having primary bone Hodgkin lymphoma (HL) which is a very rare diagnosis and rarely has been described in world literature. The most common site of extranodal lymphoma was gastrointestinal tract (7 out of 27 patients; 25.9%); the other sites reported were testis (14.8%), breast (7.4%) thyroid, and ovary. Few rare sites reported were bone, central nervous system, and mediastinum. We report an extremely rare patient who had presented with anterior chest wall swelling, and on evaluation was detected to have primary mediastinal B cell lymphoma. Conclusion: Extranodal lymphoma is the rare presentation of NHL and extremely rare for HL. As it is a very rare disease, there are very limited studies available for its staging and management. We have presented a case series of extranodal lymphoma with few very rare presentations.

Gastrointestinal (GI) Involvement with Non-Hodgkin's Lymphoma (NHL) Impacts Outcome; A Retrospective Single Tertiary Care Center Analysis of Clinico-Pathologic Characteristics Provides an Alternate Insight to Presentation and Outcome

Introduction Historically, the GI tract is involved in 10-15% of patients with newly diagnosed NHL. Despite being the predominant extranodal site for lymphoma involvement little is known about its pathophysiologic presentation given its overall rarity. Nonetheless its evaluation, diagnosis, prognosis and management is distinct from lymphomas at other sites hence their recognition irrespective of whether being the primary site is prudent. Methods We performed a single center retrospective study of patients to describe clinical characteristics and outcome of newly diagnosed NHL presenting with GI involvement defined by tissue biopsy between January 2003 and April 2019. Descriptive statistics were calculated by Fisher's exact test and Chi2 test for categorical variables and rank-sum analyses for continuous variables. Results We identified 91 patients with one patient presenting with 2 different GI NHL involvement. The median age at presentation was 70 years (range 33-92) and 61 were male. 41 (45%) patients had diffuse large B cell lymphoma (DLBCL) and 5 had concomitant low grade component, 28 (30.8%) mucosal associated lymphoid tissue (MALT) lymphoma, 10 (11%) mantle cell lymphoma (MCL), 4 (4.4%) enteropathy associated T cell lymphoma (EATL), 3 (3.3%) follicular lymphoma, 2 (2.2%) Burkitt's lymphoma and 2 (2.2%) EBV driven lymphoproliferative disorder (LPD). There were 1 case each of plasmablastic lymphoma and extranodal NK/T-cell lymphoma, nasal type. 37 with DLBCL and 2 with MCL had primary GI involvement. Gastric involvement was the commonest site, 43 (55.8%) cases followed by the large intestine, 22 (28.6%). PET-CT scan was done in 42 cases with high grade NHL; GI involvement by FDG avidity was noted in 23 cases and negative in 19 (45.2%). Serum albumin at presentation was available in all patient. Patients with presenting serum albumin < 25 g/L were more likely to die in the first 30-days post diagnosis; p<0.0001. A total of 20 patients died as a result of lymphoma; presenting serum albumin was significantly lower in that group (mean 29 g/L versus 37 g/L; p=0.0077). H pylori status was assessed by either antigen testing in stool and/or histology. This was known in 50 patients and was available by the 2 assessment methods in 31 cases but discordant in 17. A positive result was more likely noted with the antigen test. None of the T-cell LPD were H pylori positive. 12 of the 26 DLBCL and 9 (53%) of the 17 MALT lymphoma patients were H pylori status was known were positive. Nonetheless all H pylori negative MALT lymphoma cases were localized to the stomach and responded to triple eradication therapy and Rituximab monotherapy +/- surgical resection. In the DLBCL cohort, the cell of origin was known in 22 of 39 cases; 17 were non-germinal center phenotype. In the MCL cohort, all patients whom underwent surveillance endoscopies irrespective of symptoms and/or radiologic finding had histologic evidence of GI involvement with lymphoma with only 3 (18%) patients being symptomatic +/- had radiologic finding in keeping with GI involvement. Conclusions Despite the relatively small sample size this real-world data of GI lymphomas outlines some of its recognized features; advanced age at diagnosis, male prevalence and gastric involvement as the commonest site of involvement. Presenting serum albumin <25 g/L was associated with higher 30-day mortality highlighting its relevance and need for its inclusion as a biomarker in risk stratification of NHL where GI tract is involved. There is however several other significant findings not previously recognized; the incidence of GI involvement in MCL is much higher than reported; 100% in all patients whom have undergone endoscopy in our cohort suggesting that GI involvement is a feature of MCL. With only 53% of MALT lymphoma being H pylori positive which is much lower than previously described this renders the prototypical association of H pylori infection in MALT lymphoma pathogenesis void and suggests an alternate etiology. Nonetheless their response to antibiotic therapy with only minimal additional systemic therapy in some indicates that H pylori status does not necessary predict its efficacy and should be considered when treating MALT lymphomas irrespective of H pylori status. CT scans but also PET-CT scans are insensitive in detecting GI involvement even in high grade NHL. Endoscopy with random mapping biopsies even with normal macroscopic GI findings remains the gold standard. Disclosures No relevant conflicts of interest to declare.

Adult T-type lymphoblastic lymphoma presenting as hypercalcemic crisis and aplastic anemia: a case report

BackgroundHypercalcemia and aplastic anemia are two uncommon presentations of non-Hodgkin lymphoma that potentially worsen the disease prognosis. Although hypercalcemia has been reported in the B-cell subtypes and some T-cell subtypes of non-Hodgkin lymphoma, it has not been described in T-cell lymphoblastic lymphoma. The same applies to aplastic anemia, which is also not described in T-type lymphomas.Case presentationWe report a case of a 52-year-old Cameroonian man with acute kidney injury who presented with confusion, abdominal pain, constipation, polyuria, polydipsia, calciphylaxis, enlarged lymph nodes, tachycardia, and a blood pressure of 170/88 mmHg. Laboratory investigations revealed hypercalcemia (total/ionized 199.5/101.75 mg/L), normal serum phosphorus (40.20 mg/L), and a low intact parathyroid hormone (9.70 pg/ml). Complete blood count revealed pancytopenia. Peripheral blood smear confirmed thrombocytopenia but showed neither blasts nor flower cells. Bone marrow aspirate revealed hypocellularity with no blasts or fibrosis. Lymph node biopsy was suggestive of T-cell precursor lymphoma. T-lymphoblastic lymphoma presenting with hypercalcemic crisis and aplastic anemia was diagnosed, and the patient received the cyclophosphamide-doxorubicin-vincristine-prednisone protocol of chemotherapy together with filgrastim and whole-blood transfusion for aplastic anemia. The short-term outcome was fatal, however.ConclusionsSevere hypercalcemia and aplastic anemia are potential paraneoplastic syndromes of adult T-type lymphoblastic lymphoma, with fatal short-term outcome.

3044 Malignant Non-Hodgkin Lymphoma Presenting Only in the Sigmoid Colon as Suspicious Mass

INTRODUCTION: Non-Hodgkin Lymphoma (NHL) is defined as a myriad of malignant neoplasms derived from B, T, Mature B, Mature T, and NK cells. The clinical presentation of NHL varies depending of the type and the areas of involvement. Most typical can be classified into aggressive and indolent. Aggressive present acutely with a rapidly growing mass and systemic B symptoms. These include diffuse large B cell lymphoma, Burkitt lymphoma, precursor B and T lymphoblastic leukemia,/lymphoma, and Adult T cell leukemia-lymphoma. Indolent lymphomas are more insidious in nature and are slower in growth. They demonstrate slow growing hepatomegaly, splenomegaly, or cytopenias. Examples of lymphomas that typically have indolent presentations include follicular lymphoma, chronic lymphocytic leukemia/small lymphocytic lymphoma, and splenic marginal zone lymphoma. Gastrointestinal Lymphoma presents with anorexia, weight loss, nausea and vomiting. Some patients can present with GI hemorrhage and early satiety along with the mentioned symptoms listed above. CASE DESCRIPTION/METHODS: Patient is a 52 year old Hispanic woman presented outpatient for several days of diarrhea and bright red blood in the bowl. Outpatient imaging with contrast showed a soft tissue density in the left lower quadrant demonstrating inflammatory changes. Patient had no family history of CRC, other CA's or hereditary disorders. Labs demonstrated microcytic anemia and Hgb of nine. The patient received a flexible sigmoidoscopy and “25 cm from the anal verge demonstrated a large abscess appearing mass in the sigmoid colon attributable to diverticulitis.” Antibiotics were administered followed by a colonoscopy in three months. Colonoscopy demonstrated “Abscess formation 25 cm from anal verge larger than previously noted on flexible sigmoidoscopy and multiple biopsies taken and sent to pathology.” Pathology revealed “monotonous atypical infiltrate with ulceration and necrosis highly suspicious for a malignant non-Hodkin Lymphoma.” The patient was then referred to oncology and oncological surgery. DISCUSSION: This case was chosen because cases in NHL are majority male (5 to1), found on the right side of the colon (70-75% in the cecum vs 1.2-5% in the Sigmoid colon), and have B-symptoms. In our patient she had no B-symptoms and the primary presentation was in the sigmoid colon. Also, the NHL to be intramural accounts for less than 4% of all extranodal NHL. Primary site for NHL in the colon accounts for less than 1% of all acute NHL.

Pericardial effusion as initial presentation of non-hodgkin lymphoma

Pericardial effusion as initial presentation of non-hodgkin lymphoma

Primary cardiac Hodgkin lymphoma: Case report

Primary cardiac tumors are rare, with an incidence of 0,056%. The most of primary cardiac tumors are benign tumors, only 10% are malignant, and 1% from malignant tumors are primary cardiac lymphoma (PCL). From the clinical standpoint, PCL is a non-Hodgkin lymphoma presenting as cardiac disease in rightsided chambers in elderly population. It has been presented young man with Hodgkin PCL, that has been successfully treated with transplantation of the hematopoietic stem cells, leading to stable remission of the disease that has been maintained for 12 years.

Unusual Presentation of Non-Hodgkin Lymphoma of the Palate and Parotid Glands

A 57-year-old man was referred with a swelling of 10 months' evolution in the right preauricular region . Extraoral examination revealed bilateral fibroelastic preauricular swellings and a supra-auricular lymph node on the left side. Intraoral examination revealed large bilateral swellings of the hard palate, with evident surface telangiectasia. Computed tomography analysis showed hyperdense nodular images in both the superficial parotid glands. Incisional biopsy under local anesthesia was performed in the hard palate nodules, and fine-needle aspiration was performed in the right preauricular mass. Histopathologic and cytopathologic analyses were compatible with non-Hodgkin lymphoma (NHL), follicular type. Immunohistochemical positivity was detected for CD-20, CD-10, CD-79A, Bcl- 2, and Ki-67. The patient was referred to a clinical oncologist and is currently undergoing the second chemotherapy cycle with rituximab. After 15 months of follow-up, he no longer exhibits the head and neck manifestations of NHL.

Impact of HIV Infection on the Clinical Presentation and Survival of Non-Hodgkin Lymphoma: A Prospective Observational Study From Botswana.

PurposeBotswana has a high prevalence of HIV infection. Currently, there are few data regarding the sociodemographic factors, clinical characteristics, and outcomes of non-Hodgkin lymphoma (NHL)—an AIDS-defining cancer—in the country.Patients and MethodsThis study used a prospective cancer registry to identify patients with a new diagnosis of NHL reporting for specialty cancer care at three hospitals in Botswana between October 2010 and August 2016. Treatment patterns and clinical outcomes were analyzed.ResultsOne hundred four patients with a new diagnosis of NHL were enrolled in this study, 72% of whom had HIV infection. Compared with patients not infected with HIV, patients infected with HIV were younger (median age, 53.9 v 39.1 years; P = .001) and more likely to present with an aggressive subtype of NHL (65.5% v 84.0%; P = .008). All patients infected with HIV received combined antiretroviral therapy throughout the course of the study, and similar chemotherapeutic regimens were recommended for all patients, regardless of subtype or HIV status (six to eight cycles of cyclophosphamide, doxorubicin, vincristine, and prednisone; or cyclophosphamide, doxorubicin, vincristine, and prednisone plus rituximab). There was no difference in 1-year mortality among patients not infected with HIV and patients infected with HIV (unadjusted analysis, 52.9% v 37.1%; hazard ratio [HR], 0.73; P = .33; adjusted analysis, HR, 0.57; P = .14). However, when compared with a cohort of patients in the United States matched by subtype, stage, age, sex, and race, patients in Botswana fared worse (1-year mortality, 22.8% v 46.3%; HR, 1.89; P = .001).ConclusionAmong patients with NHL reporting for specialty cancer care in Botswana, there is no association between HIV status and 1-year survival.

Non-Hodgkin Lymphoma of External Auditory Canal – Uncommon Location and Related Risk Factors

Objective: Presentation of rare case report of primary non-Hodgkin Lymphoma of temporal bone secondary to immunodeficiency after prolonged steroid administration in a diabetic patient. Then review the literature of similar case reports. Method: 49 years old female presented with hearing loss, facial paralysis and otalgia. Biopsy revealed high grade non Hodgkin’s B-lymphoma. She underwent chemotherapy and had remarkable response. Result: Rapidly progressive deafness, facial paralysis and otalgia are common presentations of external canal Non-Hodgkin lymphoma. The disease is common in middle age, females and has a fair response to chemotherapy, good to radiotherapy. Surgery is an alternative method in isolated lesions or recurrent cases. Conclusion: High dose steroid and type II diabetes are potential risks for acquired immunodeficiency. External Auditory canal lymphoma is uncommon sequel. Chemotherapy is very effective in treatment of isolated cases without B symptoms

Significance of upper and lower gastrointestinal endoscopy for screening small intestinal lesions in non-Hodgkin's lymphoma

The gastrointestinal tract is a common site for the occurrence of non-Hodgkin's lymphoma (NHL). NHL with gastrointestinal lesions may lead to clinically relevant intestinal complications such as obstruction, perforation, and exsanguination during the course of the disease. Consequently, patients with NHL are often examined by means of upper and lower gastrointestinal endoscopy at the initial visit. There are no clear guidelines regarding which patients should undergo capsule endoscopy (CE) and balloon enteroscopy for detecting small intestinal lesions. We retrospectively examined the feasibility of detecting small intestinal lesions in NHL using upper and lower gastrointestinal endoscopy. Between January 2007 and October 2015, 198 patients with primary NHL were admitted to our hospital. We collected data from 51 patients with NHL with gastrointestinal lesions diagnosed through upper and lower gastrointestinal endoscopy, CE, or double balloon enteroscopy (DBE). We chosed these cases that gastrointestinal lesions was doubted by an examination for image. Nineteen of these patients presented with lymphoma at the duodenal bulb/descending part when examined by upper gastrointestinal endoscopy and at the distal ileum when examined by lower gastrointestinal endoscopy. Ectopic jejunoileal lymphoma was simultaneously detected in 13 of the 19 patients (68.4%) through the use of CE or DBE. Conversely, of the 32 patients who did not exhibit lesions at the duodenal bulb/descending part or at the distal ileum, 6 patients (18.8%) presented with small intestinal lesions, indicating a smaller percentage compared to the patients with ectopic jejunoileal lymphoma. Based on these findings, a proactive search for small intestinal lesions using CE or DBE is recommended in patients with NHL presenting with lymphoma at the duodenal bulb/descending part or at the distal ileum, as examined using both upper and lower gastrointestinal endoscopy during the initial visit.

Linfoma no Hodgkin de Mama en el Instituto Nacional de Oncología de Cuba, en el período comprendido entre 1980 y 2010.

Introducción: Los Síndromes Linfoproliferativos son procesos neoplásicos que se originan en el tejido linfoide tanto central como periférico. La presentación de Linfomas no Hodgkin de mama es infrecuente, por lo que se presenta una serie de casos de esta patología en un centro oncológico nacional en la Habana-Cuba. Métodos: El presente estudio observacional, retrospectivo fue realizado en el Instituto Nacional de Oncología de Cuba. Se revisaron historias clínicas y registros de anatomía patológica de pacientes con cáncer de mama del Instituto Nacional de Oncología y Radiobiología de Cuba, de los períodos comprendidos de enero de 1980 a diciembre de 2010. El tipo de muestreo fue no probabilístico de conveniencia. Las variables estudiadas fuero sexo, edad, diagnóstico anatomopatológico, localización de las lesiones y supervivencia. Se utiliza estadística descriptiva para datos descriptivos y Kaplan Meier para el reporte de supervivencia. Resultados: Se analizaron 14 registros de pacientes mujeres con edad media de 54.7 ±18 años. La duración de los síntomas promedio de 9.2 ±18 meses. 13 casos fueron localizados en la mama derecha (92.86 %). En diez casos (71.53 %) se presentaron con un estadio clínico I. El diagnóstico histopatológico más prevalente fue el de Linfoma No Hodgkin (LNH) difuso de células grandes B con 3 casos (21.4 %) y LNH difuso mixto de células pequeñas y grandes hendidas con 3 casos (21.4 %). Trece de los casos (92.86 %) fueron sometidos a cirugía de mastectomía, 13 casos (92.86 %) fueron sometidos a Quimioterapia y en 6 casos (42.86 %) se aplicaron sesiones de radioterapia. La supervivencia del grupo de pacientes fue reportada en 74 ±16.5 meses, (IC 95% 41.6 – 106.4). Conclusión: En esta serie de casos presentada la incidencia de Linfoma No Hodgkin de mama fue de 14 casos, el gran porcentaje en mama derecha, la supervivencia del grupo de pacientes fue de 70 meses. La histología prevalente fue de células B y Linfoma No Hodgkin difuso mixto de células pequeñas y grandes hendidas.

Case report of a rare case of Non-hodgkin Lymphoma presenting as sternal mass

Primary or metastatic tumors of the chest wall constitute 5% of all thoracic tumors and lymphoma comprises about 2% of all chest wall tumors. We report a case of a 23year old male presenting with anterior chest wall mass for the past 6 months which was slowly growing in size. There was no other symptoms of respiratory difficulty, cough, and hemoptysis. HRCT chest revealed soft tissue attenuated lesion in mid chest wall and infiltration to the anterior mediastinum with erosion of sternum and the 8th rib. FNAC of the site revealed Non-Hodgkin Lymphoma. Diagnosis is based on morphological features, FNAC, cell block.

Non-Hodgkin's Lymphoma Presenting as an Isolated Vertebral Collapse

AbstractNon-Hodgkin's lymphoma (NHL) presenting as an isolated vertebral collapse is a very rare condition. We present a case of non-Hodgkin's lymphoma presenting as L3 vertebral body collapse on MRI. Isolated vertebral involvement was seen without evidence of any lesion elsewhere. Workup for systemic evidence of malignancy with contrast-enhanced CT of chest and abdomen did not reveal any other lesion. The patient was operated for L3 transpedicular decompression and L2–L4 pedicle screw rod fixation. Biopsy revealed diffuse large B cell lymphoma (DLBCL), NOS. Diagnosis was further confirmed by a postoperative PET scan, which showed multiple deposits in perinephric fat and retroperitoneal lymph nodes. Patient was treated with CHOP-based chemotherapy.