As a general education course, College English had both instrumental and humanistic attributes (Cai, 2017), and it was an important carrier of ideological and political education. Starting from the current research status of ideological and political education of College English, this research carried out the exploration and practice of the construction approaches of it. Integrating theory with teaching practice, this research took the third version and book 3 of New Horizon College English as an example, chose part of the students of non-English majors of Grade 2019 in a university as the experimental class, and adopted the qualitative and quantitative analysis to explore the construction and practice approaches of the ideological and political education of College English from three aspects, ie. teacher’s quality, teaching resources and teaching content, so as to improve the teaching effect of ideological and political education of College English, and provide a set of approaches and methods which was universal for ideological and political education of College English. This research could also give some inspiration and guidance for the teaching reform and practice of ideological and political education of the foreign languages and other courses.