U NTIL the first part of this century the medical conception of the endocrine gIands, with the exception of the thyroid, was that of anatomica structures without function. FIajani, from cIinica1 studies, had attributed function to the thyroid gland as earIy as 1802. The first two decades of this century offered proof that nearIy a11 of the endocrine gIands had a definite function, but with the exception of the cortex of the suprarena1 gIand, none w&s shown to be essentia1 to Iife. UntiI this time these gIands were thought to be functionaIIy independent and entireIy disreIated to one another or to the organs of the non-endocrine systems. Since 1922, during the Iast ten years, their functions have been intimateIy reIated to one another and definitely associated with the functions of the non-endocrine organs through the action of their hormones. Hence, it is now known that these gIands form an interreIated system. Their inter-reIationship from the interaction of their hormones serves as the best means of endocrinic interpretation. The harmonic action of distantIy seated endocrine glands upon the genita1 system pertains particuIarIy to the practice of uroIogy and gynecoIogy. This is true because the proper balance of the interna secretions from far-removed endocrine organs are the most important factors governing both the deveIopment and function of the gonads and their accessory organs. Heretofore speciaIists in these heIds have considered their systems, excIusive of brood and nerve supply and genera1 nutritiona effects, as being independent of other bodiIy organs. For exampIe, with the exception of the pathoIogica1 processes of the uroIogica1 organs such as infections, tumors, caIcuIi, and their mechanica effects, extra-uroIogicaI conditions beyond the peIvis or the kidney have received IittIe attention as possibIe causes for their abnormaIities. The endocrine relationships of the gonads have opened up a tremendous lieId, both with regard to the growth and function of the genitive organs and their accessories. In addition, this has demonstrated positive endogenous causation for many of their maIformations and abnorma1 activities heretofore considered hopeIess and incurabIe. A better understanding of this wouId present positive indication for the preventive treatment during the adoIescent age of many of the abnormahties which the uroIogist and the gynecoIogist are caIIed upon to correct during the postadoIescent periods. The genera1 scheme of inter-reIationship of these gIands, as presented by the effect & the hormones of one upon the other, is divided into two harmonic phases. The first phase is that of the action of the homones of the thyroid, pituitary, suprarenal cortex, and thepIacenta (in the female) upon the foIIicIe of the ovary, and the spermatic capsuIe of SartoIi of the testicIe. The harmonic action of these endocrine gIands induces cytoIogica1 and functiona changes in the foIIicIe and the spermatic capsuIe which in turn resuIt in a Iiberation of hormones from these structures of the ovary and the testicIe. The second phase is that resuIting from the hormones of the ovary and the testicIe upon their accessory structures such as the uterus and its endometrium, tubes, and vagina in the female, and semina1 vesseIs, prostate,