SUMMARYThis pilot study describes the effect of wheelchair use on the quality of life of persons with multiple sclerosis (MS), and examines the clinical utility of the Psychosocial Impact of Assistive Devices Scale (PIADS) as an outcome measure for use by occupational therapists. Sixteen hospitalized adults with MS were interviewed using the PIADS. Descriptive comparisons of PIADS subscale scores (competence, adaptability, self-esteem) were conducted for participants using different types of wheelchairs, daily versus non-daily wheelchair users, and participants who required different levels of assistance to propel their wheelchairs. Results suggest that using a wheelchair has a positive impact on the quality of life of persons with MS. The PIADS was found to be clinically useful for exploring person-environment interactions and appears to be well suited to the goals and values of occupational therapy. Recommendations for future research and for incorporating the PIADS into occupational therapy practice are discussed.