Non-clinical Sample Of Adults Research Articles

Latent Typologies of Psychiatric Symptom Comorbidity With Substance Use: Associations With Adverse Childhood Experiences

Adverse childhood experiences (ACEs) and lifetime traumatic events are closely linked to development of comorbid psychiatric symptoms and substance use. Although research shows the risk for psychiatric and substance use comorbidity conferred by early adversity, most studies have not modeled multivariate symptom patterns that include posttraumatic stress disorder (PTSD) symptom criteria (i.e., re-experiencing, effortful avoidance, numbing, and hyperarousal). The aim of the present study was to model multivariate patterns of substance use and psychiatric symptoms, including PTSD criteria, and examine associations between these patterns and early adversity. Latent profile analysis (LPA) was used in a large, nonclinical sample of community adults (N = 1,431). Relations between profile membership, cumulative ACEs, and demographic covariates were then evaluated. Results indicated four distinct profiles of psychiatric symptom comorbidity (PSC): (a) PTSD dominant with elevated illicit drug and cannabis use; (b) anxiety and depression dominant with elevated use across substances; (c) avoidance dominant with low severity of all other psychiatric symptoms and substance use; and (d) psychiatrically healthy. Analyses identified significant associations between profile membership and cumulative ACEs and other traumatic events. Cumulative ACEs and traumatic events were highest among the PTSD dominant profile. A greater understanding of heterogeneous patterns of PSC may allow for future development of treatment care paths that correspond to standard criteria of symptom presentation and severity.

Empathy, Emotion Recognition, and Paranoia in the General Population.

BackgroundParanoia is associated with a multitude of social cognitive deficits, observed in both clinical and subclinical populations. Empathy is significantly and broadly impaired in schizophrenia, yet its relationship with subclinical paranoia is poorly understood. Furthermore, deficits in emotion recognition – a very early component of empathic processing – are present in both clinical and subclinical paranoia. Deficits in emotion recognition may therefore underlie relationships between paranoia and empathic processing. The current investigation aims to add to the literature on social cognition and paranoia by: (1) characterizing the relationship between paranoia and empathy, and (2) testing whether there is an indirect effect of emotion recognition on the relationship between empathy and paranoia.MethodsParanoia, empathy, and emotion recognition were assessed in a non-clinical sample of adults (n = 226) from the Nathan Kline Institute-Rockland (NKI-Rockland) dataset. Paranoia was measured using the Peters Delusions Inventory-21 (PDI-21). Empathy was measured using the Interpersonal Reactivity Index (IRI), a self-report instrument designed to assess empathy using four subscales: Personal Distress, Empathic Concern, Perspective Taking, and Fantasy. Emotion recognition was assessed using the Penn Emotion Recognition Test (ER-40). Structural equation modeling (SEM) was used to estimate relationships between paranoia, the four measures of empathy and emotion recognition.ResultsParanoia was associated with the Fantasy subscale of the IRI, such that higher Fantasy was associated with more severe paranoia (p < 0.001). No other empathy subscales were associated with paranoia. Fantasy was also associated with the emotion recognition of fear, such that higher Fantasy was correlated with better recognition of fear (p = 0.008). Paranoia and emotion recognition were not significantly associated. The Empathic Concern subscale was negatively associated with emotion recognition, with higher empathic concern related to worse overall emotion recognition (p = 0.002). All indirect paths through emotion recognition were non-significant.DiscussionThese results suggest that imaginative perspective-taking contributes to paranoia in the general population. These data do not, however, point to robust global relationships between empathy and paranoia or to emotion recognition as an underlying mechanism. Deficits in empathy and emotion recognition observed in schizophrenia may be associated with the broader pathology of schizophrenia, and therefore not detectable with subclinical populations.

How well do the Dark Triad characteristics explain individual differences in offending in a representative non-clinical adult sample?

• Psychopathy, Machiavellianism and narcissism make up the Dark Triad of personality • These Dark Triad traits were proven to be related to numerous antisocial behaviors • Such research on the Dark Triad has mainly focused on adolescent (online) samples • We tested the effect of these traits on offending in a representative adult sample • Of the three, only psychopathy and Machiavellianism were related to adult offending The present study investigates to what extent the three key concepts from the Dark Triad Theory can explain individual differences in adult offending. Data were collected through a cross-sectional survey amongst a representative sample of 1587 adults, living in Ghent, Belgium (M age = 48.06, 51.4% female). Negative binomial regression analyses are run and show that Machiavellianism and psychopathy have strong independent effects on adult offending, independent of age, sex and immigrant background.

Exploring the relationship between psychological flexibility and self-report and task-based measures of cognitive flexibility

Acceptance and Commitment Therapy (ACT) interventions aim to increase psychological flexibility (PF) leading to positive treatment outcomes. It has been suggested that successful development of PF may depend on cognitive flexibility (CF). There is however a lack of clear empirical evidence accounting for the relationship between the two constructs. The current study investigated the relationship between PF and CF in a large nonclinical sample of younger adults (N = 246). Participants completed self-report measures of PF, and both self-report and task-based measures of CF. Results indicated that self-report, but not task-based, CF correlated with and predicted PF (r = −0.49, 95% BCa CI [−0.58, −0.38], R2 = 0.236). The results are discussed with reference to rule-governed behaviour, approaches to measurement, and ACT, with suggestions for future research.

The Effect of Behavioral Activation on Older Adults' Engagement and Wellbeing: A Randomized Control Trial Protocol

Meaningful activity engagement in later life is widely recognized as crucial for ageing well, but age-related changes and transitions can impede such participation. A behavioral activation framework can provide a person-centred, value-consistent therapeutic approach to increasing activity engagement that is both easy to administer, cost effective and accessible to a broad audience. Although there is evidence supporting the utility of behavioral activation as a treatment for depression in older adults, this study will be the first to examine whether a behavioral activation is more effective in increasing activity engagement and psychological wellbeing among a non-clinical sample of older adults, compared to a multi component positive psychology intervention. This randomized controlled trial will examine the impact of two therapeutic approaches on activity engagement and wellbeing among older adults. One hundred and fifty adults aged 65+ who have relatively lower scores on a measure of engagement with life will be randomized to either a behavioral activation-based intervention, or a multi-component positive psychology intervention. The interventions will involve six individual weekly sessions conducted via telephone or video conference. Participants will be assessed pre-, post-intervention, and at three months follow-up. Outcome measures will include activity engagement, positive affect, and psychological wellbeing. Intra-individual variability will also be assessed via micro-longitudinal data in the behavioral activation condition. This study will be the first to provide evidence to the effectiveness of behavioral activation as an intervention to increase activity engagement and wellbeing among older adults, compared to other therapeutic approaches to increase psychological wellbeing.

Is there an association between prenatal testosterone and autistic traits in adolescents?

Prenatal testosterone (pT) is a crucial component in physiological masculinization in humans. In line with the Prenatal Sex Steroid Theory of autism, some studies have found a positive correlation between pT and autistic traits in childhood. However, effects in adolescence have not been explored. Hormonal and environmental changes occurring during puberty may alter the strength or the nature of prenatal effects on autistic traits. The current study examines if pT relates to autistic traits in a non-clinical sample of adolescents and young adults (N = 97, 170 observations; age 13–21 years old). It also explores pT interactions with pubertal stage and timing. PT concentrations were measured from amniotic fluid extracted in the 2nd trimester of gestation via amniocentesis conducted for clinical purposes. Autistic traits were measured by self- and parent-reports on the Autism Spectrum Quotient (AQ) which provides a total score and 5 sub-scores (social skills, communication, imagination, attention switching and attention to detail). Self-reported pubertal stage was regressed on age to provide a measure of relative timing. We found no statistical evidence for a direct association between pT and autistic traits in this adolescent sample (males, females or full sample). Exploratory analyses suggested that pT correlated positively with autistic traits in adolescents with earlier puberty-onset, but statistical robustness of this finding was limited. Further exploratory post-hoc tests suggested the pT-by-pubertal timing interaction was stronger in males relative to females, in self-reported compared to parent-reported AQ and specifically for social traits. These findings require replication in larger samples. Findings have implications for understanding the effects of pT on human behavior, specifically existence of effects in adolescence.

Transcriptome-based polygenic score links depression-related corticolimbic gene expression changes to sex-specific brain morphology and depression risk.

Studies in post-mortem human brain tissue have associated major depressive disorder (MDD) with cortical transcriptomic changes, whose potential in vivo impact remains unexplored. To address this translational gap, we recently developed a transcriptome-based polygenic risk score (T-PRS) based on common functional variants capturing 'depression-like' shifts in cortical gene expression. Here, we used a non-clinical sample of young adults (n = 482, Duke Neurogenetics Study: 53% women; aged 19.8 ± 1.2 years) to map T-PRS onto brain morphology measures, including Freesurfer-derived subcortical volume, cortical thickness, surface area, and local gyrification index, as well as broad MDD risk, indexed by self-reported family history of depression. We conducted side-by-side comparisons with a PRS independently derived from a Psychiatric Genomics Consortium (PGC) MDD GWAS (PGC-PRS), and sought to link T-PRS with diagnosis and symptom severity directly in PGC-MDD participants (n = 29,340, 59% women; 12,923 MDD cases, 16,417 controls). T-PRS was associated with smaller amygdala volume in women (t = -3.478, p = 0.001) and lower prefrontal gyrification across sexes. In men, T-PRS was associated with hypergyrification in temporal and occipital regions. Prefrontal hypogyrification mediated a male-specific indirect link between T-PRS and familial depression (b = 0.005, p = 0.029). PGC-PRS was similarly associated with lower amygdala volume and cortical gyrification; however, both effects were male-specific and hypogyrification emerged in distinct parietal and temporo-occipital regions, unassociated with familial depression. In PGC-MDD, T-PRS did not predict diagnosis (OR = 1.007, 95% CI = [0.997-1.018]) but correlated with symptom severity in men (rho = 0.175, p = 7.957 × 10-4) in one cohort (N = 762, 48% men). Depression-like shifts in cortical gene expression have sex-specific effects on brain morphology and may contribute to broad depression vulnerability in men.

Trait emotional intelligence and eating problems in adults: associations with alexithymia and substance use

Background: Eating Disorders (EDs) often co-occur with substance use contributing to increasing concern about the individual’s health; both the conditions share several core features such as the tendency to use maladaptive emotion regulation strategies. The present study investigated associations between trait emotional intelligence (Trait EI), alexithymia and EDs, namely dieting, bulimia and oral control, in a nonclinical sample of adults. Moreover, the relationships with substance use frequencies were also examined with the aim of exploring the links between personality emotional competence traits (trait EI and alexithymia) and different addictive risk behaviours (EDs and substance use) in adulthood. Methods: Data were collected from a convenience sample composed of 394 (312 women; between ages 18 and 65; mean age = 32.34; SD = 11.97) participants, through online administration of questionnaires assessing trait emotional intelligence (TEIQue-SF), eating problems (EAT-26), alexithymia (TAS-20) and frequency of substance use (in the last year). Results: The group that exceeds the cut-off for EDs (n = 58; 14.7 %) has significantly lower trait EI scores (in all dimensions) and higher alexithymia scores than the other group. Some differences between the two groups were found on frequencies of nicotine and diuretics use. Age and all trait EI factors were negatively associated with eating disorders and alexithymia. Weak inverse correlations have emerged between EI and frequencies of substance use (namely cocaine, amphetamines, alcohol and tobacco). Female gender, well-being and self-control factors of EI emerged as significant predictors of EDs in adulthood. Conclusions: Our results suggest the importance of targeting emotion dysregulation for EDs and substance use behaviours. Interventions aimed at promoting healthy lifestyles could benefit from trait EI enhancement efforts. Practitioners and health educators need to recognize the potential efficacy of including trait EI within gender specific interventions planned to address ED symptoms and addictive behaviours in general.

Exploring the impact of COVID-19-related fear, obsessions, anxiety and stress on psychological well-being among adults in Pakistan

Purpose Fear of COVID-19 is one of the pivotal components that have generated higher levels of stress, obsessions and anxiety among the adult population, thus creating numerous mental health issues. The purpose of this study was to evaluate psychological well-being based on COVID-19-related fear, obsessions and anxiety during the pandemic situation. Design/methodology/approach The current study aimed to evaluate the relationship between COVID-19-related fear, obsessions, anxiety, stress and well-being among adult populations. Additionally, the aim was to see the impact of COVID-19-related fear, obsessions, anxiety and stress on well-being. This was a cross-sectional study based on nonclinical sample of (n = 250) adults; data was obtained via online questionnaire survey method and analysis was performed by using the statistical package for social sciences (SPSS-22). Findings The authors’ findings based on descriptive statistics showed that COVID-19-related fear and obsessions were positively associated with COVID anxiety and stress and negatively associated with well-being. COVID anxiety was positively associated with stress and negatively associated with well-being. Moreover, perceived stress is negatively associated with well-being. The results additionally provide the outcome/conclusion that COVID-related anxiety significantly negatively predicted the psychological well-being. Overall the model explained 24% of the variance in psychological well-being. Females scored significantly high in COVID-19-related anxiety and obsessions as compared to males. Research limitations/implications A distinctive feature of this study is the understanding of COVID-19-related fear, obsessions, anxiety, stress and well-being among adult populations, and the findings are highlighting the need for psychological and social interventions for this specific population; therefore, immediate attention is needed by the clinical health professionals dealing with mental health issues. Originality/value There is a vital need to explore and develop psychological interventions aiming at the negative consequences being faced by the adult populations due to the COVID-19 pandemic and the impending second wave that will expose individuals to various mental health issues evolving because of the health crisis.

Traumatic Distress, Alexithymia, Dissociation, and Risk of Addiction During the First Wave of COVID-19 in Italy: Results from a Cross-sectional Online Survey on a Non-clinical Adult Sample.

This study aimed to explore the prevalence of post-traumatic distress, alexithymia, dissociation, and addictive behaviors during the stressful situation of the COVID-19 pandemic. It also aimed to determine whether trauma, alexithymia, and dissociation can effectively predict the risk of addiction in non-clinical subjects during the COVID-19 pandemic. Two hundred nineteen subjects completed a web survey during the first COVID-19 lockdown in Italy, including the Impact of Event Scale-Revised (IES-R), the Dissociative Experience Scale-II (DES-II), and the Addictive Behavior Questionnaire (ABQ). Females reported higher levels of COVID-19-related traumatic stress than males (p = 0.009). A greater fear of getting COVID-19 was associated with significantly high IES-R scores (p < 0.0005). IES-R total score was significantly lower in the “not internet-addicted” group than that in the “internet-addicted” group (p < 0.0005). Furthermore, DES-II total score was significantly higher in the “internet-addicted” group than that in the “non internet-addicted” group (p < 0.0005). No statistically significant score differences were highlighted in the “alcohol” group. Future research with longitudinal studies and larger samples will have to clarify whether trauma, alexithymia, and dissociation can effectively predict the risk of addiction in non-clinical subjects during the COVID-19 pandemic.

A common genetic variant in fatty acid amide hydrolase is linked to alterations in fear extinction neural circuitry in a racially diverse, nonclinical sample of adults.

Poor fear extinction learning and recall are linked to the development of fear-based disorders, like posttraumatic stress disorder, and are associated with aberrant activation of fear-related neural circuitry. This includes greater amygdala activation during extinction learning and lesser hippocampal and ventromedial prefrontal cortex (vmPFC) activation during recall. Emerging data indicate that genetic variation in fatty acid amide hydrolase (FAAH C385A; rs324420) is associated with increased peripheral endocannabinoid (eCB) levels and lesser threat-related amygdala reactivity. Preclinical studies link increased eCB signaling to better extinction learning and recall, thus FAAH C385A may protect against the development of trauma-related psychopathology by facilitating extinction learning. However, how this FAAH variant affects fear extinction neural circuitry remains unknown. In the present study, we used a novel, immersive-reality fear extinction paradigm paired with functional neuroimaging to assess FAAH C385A effects on fear-related neural circuitry and conditioned fear responding (US expectancy ratings, subjective units of distress, and skin conductance responding) in healthy adults from an urban area (Detroit, MI; N=59; C/C=35, A-carrier=24). We found lesser amygdala activation in A-allele carriers, compared to C/C homozygotes, during early extinction recall. Likewise, we found lesser dorsal anterior cingulate cortex and greater hippocampus activation in early extinction learning in A-carriers compared to C/C homozygotes. We found no effects of FAAH C385A on vmPFC activation or behavioral fear indices. These data support and extend previous findings that FAAH genetic variation, associated with increased eCB signaling and subsequent enhanced fear extinction, may predict individual differences in successful fear learning.

Affective correlates of negative mood regulation expectancies: A systematic review and meta-analysis

Negative mood regulation expectancies (NMRE) are individuals’ beliefs about their ability to ease unpleasant emotions. Such beliefs may influence affective states; there is, however, little knowledge on what types of affect are related to NMRE. The current review aims to identify and discuss the affective correlates of NMRE in non-clinical adult samples. We found 44 studies exploring 22 affective correlates of NMRE. There is strong and consistent evidence of relations between NMRE and depression, anxiety, stress, negative affect, and positive affect, with low NMRE related to high negative affect variables and low positive affect variables. Limited evidence indicates negative relationships of NMRE to burnout, shame, and loneliness. The results are relevant to clinical practice, research, and theory development.

Mentalizing mediates the association between emotional abuse in childhood and potential for aggression in non-clinical adults

BackgroundEmotional abuse in childhood has been linked to a higher expression of aggressive behavior in adulthood. The identification of protective factors that mitigate this association is needed. Mentalizing—the capacity to understand behavior in terms of intentional mental states—appears to be a promising candidate factor that possibly modifies maladaptive consequences of early emotional abuse. ObjectiveThis study investigated associations between the history of emotional abuse, aggressive behavior in adulthood and mentalizing capacities in a non-clinical sample of adults. Methods214 healthy adults completed questionnaires measuring retrospectively rated experiences of emotional abuse in childhood, mentalizing capacities and aggressive behavior in a cross-sectional design. ResultsResults indicated associations between emotional abuse in childhood, uncertainty about mental states, and aggressive behavior in adulthood. Moreover, certainty about mental states counteracted the negative effect of emotional abuse and partially mediated the associations between emotional abuse and aggressive behavior in adulthood. ConclusionThis study extends current research and sheds further light on the relationship between emotional abuse in childhood, the health-promoting capacity of mentalizing, and aggressive behavior in non-clinical adults.

Compliance With Mobile Ecological Momentary Assessment of Self-Reported Health-Related Behaviors and Psychological Constructs in Adults: Systematic Review and Meta-analysis.

BackgroundMobile ecological momentary assessment (mEMA) permits real-time capture of self-reported participant behaviors and perceptual experiences. Reporting of mEMA protocols and compliance has been identified as problematic within systematic reviews of children, youth, and specific clinical populations of adults.ObjectiveThis study aimed to describe the use of mEMA for self-reported behaviors and psychological constructs, mEMA protocol and compliance reporting, and associations between key components of mEMA protocols and compliance in studies of nonclinical and clinical samples of adults.MethodsIn total, 9 electronic databases were searched (2006-2016) for observational studies reporting compliance to mEMA for health-related data from adults (>18 years) in nonclinical and clinical settings. Screening and data extraction were undertaken by independent reviewers, with discrepancies resolved by consensus. Narrative synthesis described participants, mEMA target, protocol, and compliance. Random effects meta-analysis explored factors associated with cohort compliance (monitoring duration, daily prompt frequency or schedule, device type, training, incentives, and burden score). Random effects analysis of variance (P≤.05) assessed differences between nonclinical and clinical data sets.ResultsOf the 168 eligible studies, 97/105 (57.7%) reported compliance in unique data sets (nonclinical=64/105 [61%], clinical=41/105 [39%]). The most common self-reported mEMA target was affect (primary target: 31/105, 29.5% data sets; secondary target: 50/105, 47.6% data sets). The median duration of the mEMA protocol was 7 days (nonclinical=7, clinical=12). Most protocols used a single time-based (random or interval) prompt type (69/105, 65.7%); median prompt frequency was 5 per day. The median number of items per prompt was similar for nonclinical (8) and clinical data sets (10). More than half of the data sets reported mEMA training (84/105, 80%) and provision of participant incentives (66/105, 62.9%). Less than half of the data sets reported number of prompts delivered (22/105, 21%), answered (43/105, 41%), criterion for valid mEMA data (37/105, 35.2%), or response latency (38/105, 36.2%). Meta-analysis (nonclinical=41, clinical=27) estimated an overall compliance of 81.9% (95% CI 79.1-84.4), with no significant difference between nonclinical and clinical data sets or estimates before or after data exclusions. Compliance was associated with prompts per day and items per prompt for nonclinical data sets. Although widespread heterogeneity existed across analysis (I2>90%), no compelling relationship was identified between key features of mEMA protocols representing burden and mEMA compliance.ConclusionsIn this 10-year sample of studies using the mEMA of self-reported health-related behaviors and psychological constructs in adult nonclinical and clinical populations, mEMA was applied across contexts and health conditions and to collect a range of health-related data. There was inconsistent reporting of compliance and key features within protocols, which limited the ability to confidently identify components of mEMA schedules likely to have a specific impact on compliance.

Does physical appearance perfectionism predict disordered dieting?

Despite that disordered eating has been repeatedly associated with perfectionism, the results are inconsistent as to which exact dimensions of perfectionism it is related to. Moreover, the increasing evidence that perfectionism is best conceptualized as a domain-specific, as opposed to a global, trait contribute to the lack of clarity. Therefore, the aim of this study was to examine which dimensions of global and physical appearance perfectionism statistically predict disordered dieting in a non-clinical adult female sample. In total 437 participants completed the Short Almost Perfect Scale, which distinguishes between adaptive and maladaptive perfectionism, the Physical Appearance Perfectionism Scale, which distinguishes between hope for perfection and worry about imperfection, and the Dieting subscale of the Eating Attitudes Test-26. A hierarchical regression analysis revealed that only maladaptive, as opposed to adaptive, global perfectionism statistically predicted disordered dieting. Furthermore, both dimensions of physical appearance perfectionism statistically predicted disordered dieting, although worry about imperfection, its maladaptive dimension, was the strongest statistical predictor. The present results demonstrate that worry about imperfection is an effective statistical predictor of disordered dieting among women, possibly serving as a starting point for further research investigating the utility of its incorporation in prevention and treatment protocols for disordered eating.

Événements traumatogènes, âge de survenue, symptômes anxio-dépressifs et comportements addictifs dans un échantillon de jeunes adultes recruté en ligne

ObjectivesIn France, the prevalence of post-traumatic stress disorder is estimated around 3,9 %, yet very few studies have been conducted on potentially traumatic events in French samples, in particular in a population of young adults. Moreover, the severity of the act (violence and repetition) and the age of the victim seem to be aggravating factors in the development of psychiatric symptoms. Our main objective was to examine the distribution of potentially traumatic events in a non-clinical sample of young adults and to study their relationships between traumatic events, addictive behaviors, and depressive and anxiety symptoms. We also paid particular attention to the impact of their age at the time of the events and the repetition of these events. Materials and methodsA sample of 735 participants, aged from 18 to 35 years (M=22.6; SD=4) completed a questionnaire on the Internet. Several scales have been used including the Trauma History Questionnaire, the Impact of Event Scale-Revised, the Center for Epidemiologic Studies Depression Scale, the Penn State Worry Questionnaire, and the Shorter Promis Questionnaire for assessing addictive behaviors. Sub-groups, according to the age of the person at the time of the first potentially traumatic event and the type of the event, were created in order to identify risk groups. ResultsOur results showed that more than 90 % of the sample reported at least one potentially traumatic event while approximately 60 % reported repeated traumatic events. There were 21 % to significantly suffer from post-traumatic stress symptoms, 29 % from generalized anxiety symptoms and 37 % from depressive symptoms. The higher risk periods for being the victim of sexual or physical assaults were preadolescence and adolescence. Among addictive disorders, substances, tobacco and alcohol had higher mean scores; among behaviors, it was bulimia, work and shopping. Besides these, compulsive helps had scores around twice higher than the other relationships. There was a correlation between traumatic events and anxiety disorders, depressive symptoms, and addictive behavior related to sex, work, sport, and relationship. Multiple regression analysis revealed that depressive symptomatology was highly explained by the presence of some addictive behaviors while generalized anxiety and post-traumatic stress symptoms were less explained by these behaviors. ConclusionsOur study showed that potentially traumatic events appear more frequently than on other studies. Moreover, these events were associated with numerous psychiatric symptoms, including multiple addictive behaviors. Those events and post-traumatic stress symptoms had a more sizable presence, compared to results in previous studies. Descriptive analysis underlined the vulnerability of children confronted with repeated traumatic events. These results suggest the importance of setting specific preventive actions up, according to age, in particular with adolescents and pre-adolescents, who seem to be the most affected by physical and sexual aggressions.

Ability to initiate relationships and sense of loneliness mediate the relationship between low self-esteem and excessive internet use

The purpose of the study was to identify possible mechanisms underlying the relationship between low self-esteem and excessive Internet use in a non-clinical sample of young adults. Basing on the theoretical framework and results of existing studies we hypothesized that the association between self-esteem and excessive Internet use will be serially mediated by the ability to initiate contact with others and sense of loneliness. The study sample consisted of 506 participants (60% women) aged between 18 and 35 years (mean = 19). The following questionnaires were administered: the Rosenberg Self-Esteem Scale, the UCLA Loneliness Scale, the Interpersonal Competence Questionnaire and the Excessive Internet Use Scale. The last measure was prepared by authors for the purpose of the study. Serial mediation analysis was conducted. In line with our hypotheses the link between low self-esteem and excessive Internet use was found to be sequentially mediated by the capability to initiate social contacts and chronic loneliness. Difficulty in engaging in social interaction leading to the sense of loneliness may explain the link between low self-esteem and excessive Internet use. These results may help to design early intervention programs.

On the (lack of) association between theory of mind and executive functions: a study in a non-clinical adult sample

We investigated in a sample of non-clinical adults the association between Theory of Mind (ToM) and Executive Functions (EFs), that is the set of skills that allow people to control and modulate lower-level cognitive processes in order to produce appropriate behaviour. To this aim, we assessed both affective (i.e., understanding other people’s emotions and feelings) and cognitive (i.e., understanding others’ beliefs and intentions) ToM, as well four subcomponents of EFs, that is Updating, Shifting, Inhibition, and Access. The association between ToM and non-verbal fluid intelligence, verbal reasoning, and cognitive estimation abilities was also investigated. Eighty-one healthy participants were recruited, and a set of psychometrically validated tests was administered. Multiple regression analyses were run to assess significant predictors of ToM performance when potentially confounding predictors (sociodemographic variables) were controlled for. Results showed a lack of association between affective/cognitive ToM and EFs, whereas non-verbal fluid intelligence for cognitive ToM and verbal reasoning for affective ToM were found to be significant predictors of ToM performance. These results represent a contribution toward a deeper understanding of the ToM-EFs relationships and highlight the importance of broadening the analysis of these relationships to the role played by other domain-general functions in both affective and cognitive ToM.

Effects of childhood trauma experience and BDNF Val66Met polymorphism on brain plasticity relate to emotion regulation

Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism may modulate the link between childhood trauma experience and psychopathology by altering trophic signaling on neuroplasticity. However, few multimodal magnetic resonance imaging (MRI) researches have investigated this gene-environment interaction on both structural and functional plasticity, thereby advancing knowledge about the etiology, prevention, and customized therapeutic directions of mental disease in individuals with childhood trauma experience. We recruited a large non-clinical sample of young adults that completed Childhood Trauma Questionnaire (CTQ), behavioral scores, multimodal MRI scans, and genotyping. Morphometric similarity network (MSN) and independent component analysis were adopted to quantify brain structural and functional changes. Gene-environment-brain-behavior relationships were identified by multiple regression and mediation effect analysis. CTQ score was positively associated with depression and anxiety scores. We found interactions on MSN in sensorimotor, temporal, and orbitofrontal cortex. For intra-network connectivity, significant interaction was noted in clusters within sensorimotor network. For inter-network connectivity, connectivity between dorsal attention network and salience network showed an interactive effect. For mean connectivity strength of each network, we found a main effect of CTQ score on self-reference network that was an outstanding mediator supporting the relationship between CTQ score and anxiety. Our findings demonstrate that childhood trauma and the BDNF Val66Met polymorphism are associated with brain plasticity involving emotion regulation, structurally and functionally, which may contribute to understanding psychotic mechanisms and predicting differential susceptibility. Imaging genetics may be useful as biomarkers to provide early assessment and guide cognitive interventions to avoid or decrease the risk of developing psychopathology.

Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study.

Childhood adversity may act as a stressor to produce a cascade of neurobiological effects that irreversibly alter neural development, setting the stage for developing psychopathology in adulthood. The catechol‐O‐methyltransferase (COMT) Val158Met polymorphism has received much attention as a candidate gene associated with environmental adversity, modifying risk for psychopathology. In this study, we aim to see how gene × brain × environment models give a more integrative understanding of brain modifications that contribute to predicting psychopathology related to childhood adversity. A large nonclinical sample of young adults completed Childhood Trauma Questionnaire (CTQ), behavioral scores, multimodal magnetic resonance imaging (MRI) scans, and genotyping. We utilized graph‐based connectivity analysis in morphometric similarity mapping and resting‐state functional MRI to investigate brain alterations. Relationships among COMT genotypes, CTQ score, imaging phenotypes, and behavioral scores were identified by multiple regression and mediation effect analysis. Significant main effect of CTQ score was found in anatomic connectivity of orbitofrontal cortex that was an outstanding mediator supporting the relationship between CTQ score and anxiety/harm‐avoiding personality. We also noted the main effect of childhood trauma on reorganization of functional connectivity within the language network. Additionally, we found genotype × CTQ score interactions on functional connectivity of the right frontoparietal network as well as anatomic connectivity of motor and limbic regions. Our data demonstrate childhood adversity and COMT genotypes are associated with abnormal brain connectivity, structurally and functionally. Early identification of individuals at risk, assessment of brain abnormality, and cognitive interventions may help to prevent or limit negative outcomes.