You have accessJournal of UrologyKidney Cancer: Localized: Surgical Therapy I (PD02)1 Apr 2020PD02-06 CLINICAL CHARACTERISTICS, PERIOPERATIVE AND ONCOLOGICAL OUTCOMES FOLLOWING SURGICAL TREATMENT FOR RENAL CELL CARCINOMA IN PATIENTS ≤40 YEARS: DATA FROM THE LATIN AMERICAN RENAL CANCER GROUP (LARCG) Adrian Garza-Gangemi*, Ricardo A. Castillejos-Molina, Alejandro Nolazco, Buenos Aires, José Campos-Salcedo, Edgar Bravo, Ignacio Tobia, Buenos Aires, Ana Maria Autrán-Gomez, Joan Palou, Diego Abreu-Clavijo, Stenio de Cassio Zequi, and Francisco Rodríguez-Covarrubias Adrian Garza-Gangemi*Adrian Garza-Gangemi* More articles by this author , Ricardo A. Castillejos-MolinaRicardo A. Castillejos-Molina More articles by this author , Alejandro NolazcoAlejandro Nolazco More articles by this author , Buenos AiresBuenos Aires More articles by this author , José Campos-SalcedoJosé Campos-Salcedo More articles by this author , Edgar BravoEdgar Bravo More articles by this author , Ignacio TobiaIgnacio Tobia More articles by this author , Buenos AiresBuenos Aires More articles by this author , Ana Maria Autrán-GomezAna Maria Autrán-Gomez More articles by this author , Joan PalouJoan Palou More articles by this author , Diego Abreu-ClavijoDiego Abreu-Clavijo More articles by this author , Stenio de Cassio ZequiStenio de Cassio Zequi More articles by this author , and Francisco Rodríguez-CovarrubiasFrancisco Rodríguez-Covarrubias More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000822.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Renal Cell carcinoma is rare in patients under 40 years of age and data regarding presentation and clinical outcomes in this patient population is limited and inconsistent in literature. The aim of this study was to describe the characteristics, perioperative and oncological outcomes of renal cell carcinoma (RCC) surgery in patient’s ≤40 years of age. METHODS: This is a retrospective study of prospectively collected data of 4101 patients who underwent treatment for RCC from 1990-2015 in 28 centers from 8 Latin American countries and Spain. We compared baseline characteristics as well as clinical, perioperative and oncological outcomes according to age groups (≤40 vs. > 40 years). Surgical complications were classified with the Clavien-Dindo score. We calculated overall survival, cancer specific survival and progression free survival using Kaplan-Meier method and log-rank test. RESULTS: The median follow-up was 20 ± 42 months. There were 332 patients (8.1%) ≤40 years of age. On bivariate analysis, younger patients had a better performance status (ECOG 0-1 in 5.4% vs. 6.7% p< 0.01) and lower ASA score. Earlier clinical stages (CS) were more frequent in patients under 40 years of age (CS I-II in 82.9% vs 70.3%, p<0.01) as well as other histologic subtypes (non clear cell RCC), specifically chromophobe RCC (8.5% vs. 4.6%, p<0.005). Additionally, Multifocality and a lower pT stage were more commonly observed in younger patients. There were no differences in surgical time, surgical margins, and overall complication rates. The primary tumor treatment modality of choice more commonly performed was partial nephrectomy in patients ≤ 40 years. There were no differences in cancer specific survival (p= 0.06) and progression free survival (p= 0.45) between study groups. CONCLUSIONS: Latin American patients under 40 years of age are more commonly associated with an early clinical stage at presentation, smaller pT tumors and non-clear cell histology, particularly chromophobe RCC. Perioperative and oncological outcomes are similar compared to their older counterparts. Source of Funding: None © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e68-e68 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Adrian Garza-Gangemi* More articles by this author Ricardo A. Castillejos-Molina More articles by this author Alejandro Nolazco More articles by this author Buenos Aires More articles by this author José Campos-Salcedo More articles by this author Edgar Bravo More articles by this author Ignacio Tobia More articles by this author Buenos Aires More articles by this author Ana Maria Autrán-Gomez More articles by this author Joan Palou More articles by this author Diego Abreu-Clavijo More articles by this author Stenio de Cassio Zequi More articles by this author Francisco Rodríguez-Covarrubias More articles by this author Expand All Advertisement PDF downloadLoading ...