Abstract Objective: Aim of this study was to analyze the association of chronic kidney disease (CKD) with survival of patients after first ischemic stroke in the Croatian cohort of the ESH Stroke Survey. Design and method: Consecutive sample of 292 patients (171 m, average age 64 y) who were admitted to UHC Zagreb and diagnosed with ischemic stroke between 2011- 2014 were included in this analyses. Patients were followed-up for 2350 days. Mortality data were obtained from Croatian National Public Health archive. CKD was defined as eGFR < 60 ml/min/1,73m2 (CKD-Epi). Results: Previously we reported that hypertension, smoking, diabetes, dyslipidemia and atrial fibrillation were diagnosed in 75%, 27.3%, 24.5%, 17.4%, and 11.7% of patients, respectively. CKD was diagnosed in 51.7%. CKD stages 1, 2, 3a, 3b, 4, 5 were confrimed in 6.8%, 41%, 31.8%, 14.7%, 3.4% and 1.7% of patients, respectively. During the follow-up period 91 patients (31.1%) died from stroke, CV diseases, cancer and other causes (60.4%, 9.8%, 14.2% and 15.3%, respectively). We also reported that stroke deaths and CV composite deaths were more frequently present in CKD than in non-CKD patients p < 0.001). Here we are reporting that patients with CKD (both gender) lived significantly shorter than non-CKD patients (2290 days vs. 2546 days, p < 0.001). Even patients in CKD stages 3a/3b survived significantly shorter than patients in CKD stages 1 and 2. Conclusions: High prevalence of CKD was observed in our cohort of patients who survived first ischemic stroke. We confirmed previous results that CKD is significantly associated with survival after stroke and found that even CKD stage 3a is associated with shorter survival than non-CKD patients indicating that CKD should be considered as an independent prognostic factor in patients with ischemic stroke.