Two new fields are introduced to the sensor community: strained induced piezotronics for smart CMOS and a nanogenerator that harvests mechanical energy for powering nanosystems. Fundamentally, due to the polarization of ions in a crystal that has non-central symmetry, such as ZnO, GaN and InN, a piezoelectric potential (piezopotential) is created in the crystal by applying a stress. We have replaced the externally applied gate voltage to a CMOS field effect transistor by the strain induced piezopotential as a “gate” voltage to tune/control the charge transport from source to drain. The devices fabricated by this principle are called piezotronics, with applications in strain/force/pressure triggered/controlled electronic devices, sensors and logic units. The principle of harvesting irregular mechanical energy by the nanogenerator relies on the piezopotenital driven transient flow of electrons in external load, which can be resulted from body motion, muscle stretching, breathing, tiny mechanical vibration/disturbance, sonic wave etc. As of today, a gentle straining can output 1-3V at an instant output power of ∼2μW from an integrated nanogenerator of a very thin sheet of 1cm2 in size. This technology has the potential applications for power MEMS/NEMS that requires a power in the μW to mW range.