WCN 2013 No: 2401 Topic: 3 — Stroke Red blood cell distribution width (RDW) association with ischemic stroke among adults younger than 55 years I. Alimehmeti, S. Grabova, E. Lekli, D. Keri, H. Doci, E. Konda, I. Zekja, S. Xhaxho, J. Kruja. Endocrinology, UHC Mother Theresa, Tirana, Albania; Neurology, UHC Mother Theresa, Tirana, Albania; Faculty of Medicine, Tirana, Albania Background: Red blood cell distribution width (RDW) measures the size variability of these cells. It has been recently reported as a novel independent marker of macrovascular disease, including stroke, even at normal range values. Objective: Evaluation of RDW values in adults younger than 55 years presenting with ischemic stroke. Patients andmethods:All patients aged under 55 years and presenting with ischemic stroke during 2012 were enrolled. Socio-demographic information was registered before clinical examination in addition to RDW, cholesterol, triglycerides, smoking, alcohol use, presence of diabetes and arterial hypertension. Cases with anemia were excluded. Results: 158 patients (133 males, 25 females), aged 16–55 years (mean 48.4 years, SD 7.22) presented with ischemic stroke. RDW values were 14.27% (SD 1.1%, normal range being 10–15%). No case presented with RDW under 12%. Cases were divided in quartiles: 9.6% had 12–13% RDW value (1st quartile), 30.8% had 13–14% RDW value (2nd quartile), 34.6% had 14–15% RDW value (3rd quartile), and 25% had N15% RDW value. Hypertension was present in 90 patients (57%). Diabetes was present in 42 patients (26.6%). 58 patients (36.7%) were smokers. 48 patients (30.9%) were alcohol users. Mean cholesterol level was 211.4 mg/dl (SD 66.71 mg/dl). Mean triglyceride level was 170.3 mg/dl (SD 95.32 mg/dl). Conclusions: Adults under 55 years of age presenting with ischemic stroke have upper normal or over the range RDW values, therefore RDWmay be of great help as a future risk marker for ischemic stroke, being a cheap and readily available clinical laboratory examination. doi:10.1016/j.jns.2013.07.966 Abstract — WCN 2013 No: 2659 Topic: 3 — Stroke Influence of antiplatelet treatment on the NIHSS score after intravenous thrombolysis WCN 2013 No: 2659 Topic: 3 — Stroke Influence of antiplatelet treatment on the NIHSS score after intravenous thrombolysis Y. Sung Hoon, H. Eisuke, N. Masao. Cerebrovascular Division, Kohnan Hospital, Sendai, Japan; Neurology and the Center for Stroke and Neurocritical Care, International University of Health and Welfare Atami Hospital, Atami, Japan Background and aims: The influence of antiplatelet treatment on the NIHSS scores and the risk of cerebral hemorrhage after intravenous rt-PA are not well known.We assessed the effect and the safety of rt-PA under antiplatelet agents (AP). Methods: We studied data from 78 patients with ischemic stroke undergoing intravenous rt-PA within 3 h after onset, between April 1, 2006 and November 30, 2011. The patients with anticoagulation were excluded. Neurological improvement is defined by reduction of 2 points in the NIHSS score within the first 24 h after intravenous rt-PA. We assessed all 6 h and 24–36 h follow-up CT and MRIs for cerebral hemorrhage. Results: 70 patients were included; 50 men, mean age of 71 ± 11, 20 patients used AP prior to rt-PA, 14 with aspirin, 1 with ticlopidine, 1 with clopidogrel, 1 with cilostazol, 1 with cilostazol and clopidogrel, and 1 with aspirin and ticlopidine. The proportion of patients with recovery on the NIHSS scores was 18 patients in the AP group, 28 patients in the non-AP. Recovery on the NIHSS scores was higher in the AP group compared to the non-AP group. Any type of cerebral hemorrhage was observed: 4 patients in the AP group, 19 patients in the non-AP group. There is no significant difference between the AP group and non-AP group. None of the patients between two groups experienced symptomatic cerebral hemorrhage. Conclusions:Our study disclosed that intravenous rt-PAwith patients using AP is effective and safe. doi:10.1016/j.jns.2013.07.967 Abstract — WCN 2013 No: 2655 Topic: 3 — Stroke Risk factors and etiology of ischemic stroke in young adults admitted to the stroke unit of Policlinico “Gemelli” of Rome WCN 2013 No: 2655 Topic: 3 — Stroke Risk factors and etiology of ischemic stroke in young adults admitted to the stroke unit of Policlinico “Gemelli” of Rome R. Renna, F. Pilato, P. Profice, V. Di Lazzaro. Dipartimento di Geriatria, Neuroscienze ed Ortopedia, Catholic University of Sacred Heart, Italy; Institute of Neurology, Campus Bio-Medico University,