Non-anemic Mothers Research Articles

The association between maternal anemia and neonatal anemia: a systematic review and meta-analysis

ImportanceNeonatal anemia has a long-term effect on children's growth and development. Anemia during pregnancy is also the most widespread nutritional deficiency among pregnant women in the world; If it leads to anemia in newborns, it will affect a wide range of people and be a public health problem worthy of attention.ObjectiveTo study the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.Data sourcesPubMed, Web of science, Scopus, MEDLINE, Embase, ProQuest, Dissertations & Theses Global, The Cochrane Library, China Biology Medicine Database, Chinese CNKI Database, and Chinese Wanfang Database were systematically searched from inception to August 31, 2022.Study selectionThe meta-analysis included all original studies which pertain to cohort studies, case-control studies or cross-sectional studies that investigated the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.Data extraction and synthesisHemoglobin level of both anemic and non-anemic pregnant mothers and their paired newborns were pooled from the selected studies. The random-effects model was used to assess the risk of getting a lower neonatal hemoglobin level between mothers with and without pregnant anemia. Data analyses were performed from September 5, 2022, to March 10, 2023.Main outcomes and measuresMaternal anemia during pregnancy is a risk factor of lower neonatal hemoglobin levels.ResultsThe initial search yielded 4267 records of which 116 articles underwent full-text evaluation, which identified 18 articles and a total of 1873 patients that were included. The findings of the meta-analysis showed a significant difference between the two groups(MD=-1.38; 95%CI:[-1.96,-0.80]. p<0.01), while the co-effect showed that the neonatal hemoglobin value of anemic mothers was 1.38g/dL lower than that of non-anemic mothers(-1.96,-0.80), suggesting a correlation between maternal anemia lower neonatal hemoglobin levels.Conclusions and relevanceThis systematic review and meta-analysis demonstrated that maternal anemia during pregnancy were associated with a lower level of newborn hemoglobin levels. This may enable a better understanding of neonatal anemia and provide guidance towards future development of nutritional supplementation during pregnancy and the prediction of postpartum outcomes.Trial registrationPROSPERO Identifier: CRD42022352759.

Birth weight mediates the association of maternal undernutrition with child undernutrition prevalence in West Africa.

Maternal nutritional status before and during pregnancy is an important determinant of foetal health. In West Africa, maternal and child undernutrition remains a major public health problem and it is important to establish the mechanistic pathway linking the two disorders to help address the problem. We therefore assessed the mediating role of low birth weight (LBW) in the relationship of maternal undernutrition with child undernutrition in West Africa. We included recent (2010-2019) DHS data from thirteen West African countries. Poisson regression model with robust standard errors was used to assess the relationship between maternal undernutrition (body mass index and anaemia) and child undernutrition (stunting, wasting, underweight, and anaemia). Structural equation modelling was used to conduct the mediation analysis. Prevalence of stunting, wasting, underweight, and anaemia among under-five children in West Africa was found to be 32.4%, 8.1%, 20.1%, and 71.5%, respectively. We found children of underweight mothers to be more likely to be undernourished (stunted, wasted, and underweight) and anaemic compared to children of normal-weight mothers. Also, children of anaemic mothers were more likely to be stunted and anaemic but not wasted compared with children of non-anaemic mothers. LBW mediated the observed relationships between maternal BMI and childhood stunting (22.6%), and maternal anaemia and childhood stunting (24.9%), wasting (11.7), and anaemia (6.6%). We found maternal undernutrition to be associated with child undernutrition in West Africa with LBW noted to be a mediator of the observed relationship. We recommend that, to address the child undernutrition problem in West Africa, governments and policymakers must integrate measures to address the burden of LBW.

Study on the Effect of Maternal Haemoglobin on Birth Weight of Newborn Babies

Background: Anemia is a very common condition found in pregnant women, which has a deleterious effect on foetal wellbeing including weight gain of fetus. Studies indicate that anemia in pregnancy is a risk factor low birth weight and possibly for inferior neonatal health. The present study is done to determine the effect of the maternal hemoglobin on birth weight. Methods: An observational cross-sectional study was carried out at a tertiary care hospital in Mumbai. All pregnant females with single live pregnancy were included in this study. After the selection criteria was satisfied, all term babies born to pregnant females with single live pregnancy were examined and birth weight was recovered on a digital weighing scale. Results: Among the anemic mothers, 39 (27.3%) had mild anemia (Hb: 10 – 10.9), 32 (22.4%) had moderate anemia (Hb: 7 – 9.9) and 9 (6.3%) had severe anemia (Hb: &lt;7). Of the 143 newborns born to those mothers, 74 (51.7%) weighed between 2500 – 3500 grams, 56 (39.2%) were low birth weight (&lt;2500g) babies and only 13 (9.1%) were above 3500 grams. Conclusions: According to our study, anemic mothers delivered babies with low birth weight than nonanemic mothers. Present study showed prevalence of low-birth-weight babies to be 39.2%. Interventions to reduce low birth weight should be specific for specific populations. Approaches to improve the health of the women are needed to reduce the low-birth-weight problem in India. Keywords: Maternal haemoglobin, Anemia, Low birth weight.

Determinants of normal haemoglobin concentration among under-five children in Sub-Saharan Africa: a Positive deviance inquiry using cross-sectional study design

BackgroundLow haemoglobin level in children is linked with short-term and long-term consequences including developmental delay. Globally, over half of the children under the age of five years had low haemoglobin...

HIGHER MATERNAL EDUCATION AND NON-WORKING MOTHER AS A STRONG DETERMINANT OF HIGHER MATERNAL LEVEL OF KNOWLEDGE ON IRON SUPPLEMENTATION IN BANTUL DISTRICT, YOGYAKARTA, INDONESIA

In Indonesia, maternal anemia, which affects nearly half of pregnant women, is still a growing nutritional issue. Several negative impacts of maternal anemia have been validated, including its effect on their offspring such as low birthweight and risk of being stunting. Maternal knowledge affects maternal compliance on iron supplementation consumption which significantly correlated with maternal anaemia status. This study aimed to investigate determinants of maternal knowledge on iron supplementation. A total of 121 pregnant women from Pajangan Sub-District in Bantul participated in this cross-sectional study. A bivariate and multivariate analysis conducted to investigate the correlations of each independent variable to the outcome. The crude and adjusted OR showed that higher mothers’ education level (AOR=3.77, CI=1.184 – 11.98), unemployeed mothers (AOR =2.99, CI = 1.02 – 8.77) and non-anaemic mothers (AOR=5.14, CI=1.51 – 17.45) associated significantly with higher iron supplementation knowledge. Maternal pregnancy status (gravidity and age of pregancy) as well as family income were not associated with maternal knowledge. Information regarding iron supplementation enhancer, inhibition and side effects should be promoted more among mothers. Health practitionaires should also provide health promotion at the workspace to reach employeed mothers in improving healthy pregnancy literacy.

Effect of Maternal Hemogloblin on Anthropometric Measurments of Newborns

Objective: To determine the effect of maternal hemoglobin on the anthropometric measurements of newborns. Study design: Prospective cross-sectional study. Place and duration of study: Neonatal and Obstetric Department of Combined Military Hospital, Quetta Pakistan, from Jan 2020 to Jun 2020. Methodology: All newborn babies born during the study period were enrolled in the study. Anthropometric measurement of the newborn such as length, weight, fronto-occipital circumference (FOC), and mid chest circumference (MCC) were recorded. Moreover, latest maternal hemoglobin level in third trimester of pregnancy was observed. Results: Of 357 patients, mean newborn weight, length, FOC, and MCC were 3032.8±409.3 grams, 48.16±4.57 cm, 35.26±3.77 cm, and 32.15±1.94 cm respectively. Anemia was observed in 164(45.9%) mothers [118/164 (72%) had mild whereas 46/164(28%) had moderate anemia]. Amongst 118 mild anemic mothers, mean newborn weight, length, FOC, and MCC were 2994.9±351.9 grams, 48.43±4.45 cm, 35.08±3.64 cm, and 32.01±1.47 cm respectively. While amongst 46 moderate anemic mothers, mean newborn weight, length, FOC, and MCC were 2726.17±347.51 grams, 47.54±3.02 cm, 34.09±1.38 cm, and 31.14±2.36 cm respectively. Mean weight (p&lt;0.001), fronto-occipital circumference (p 0.035), and MCC (p&lt;0.001) was significantly lower among anemic mothers than non-anemic mothers. A positive significant correlation of maternal hemoglobin level was observed with newborn weight (r=0.176, p 0.001) and MCC (r= 0.194, p&lt;0.001). Conclusion: A considerably negative impact of maternal anemia was observed on weight, FOC, and MCC of the newborn.

Prevalence of anemia and comparison of perinatal outcomes among anemic and nonanemic mothers.

The prevalence of anemia is a significant public health challenge. Approximately half of all pregnant women in India experience anemia during pregnancy. This study aims to determine the prevalence of anemia and perinatal outcomes among anemic and nonanemic pregnant mothers. The quantitative research approach was adopted using a descriptive comparative design. The study was conducted in the Obstetrics and Gynecology and Pediatric departments of a tertiary care hospital. Hemoglobin (Hb) was recorded using antenatal records of pregnant mothers in their III trimester. Based on their Hb level, subjects were divided into two groups, anemic and nonanemic as per World Health Organization criteria. The subjects were followed up until the first week after birth. The prevalence of anemia was 48% [N = 410]; 70.6% had mild, 13.7% had moderate, and 15.7% had severe. The anemic group had a significantly higher incidence of low birthweight (30.9% vs 10.3%, P = 0.001) and preterm births (24.2% vs 3.2%, P = 0.001) compared to the nonanemic group. Additionally, there were significant differences in various quantitative perinatal parameters such as weight (P = 0.001), length (P = 0.001), head circumference (P = 0.001), chest circumference (P = 0.034), APGAR score at one minute (P = 0.022), and APGAR score at five minutes (P = 0.001) between the anemic and nonanemic. The maternal anemia is associated with increased risk of unfavorable perinatal outcomes. Identifying and managing anemia among pregnant women is critical to minimize adverse outcomes. Adequate antenatal care can play a significant role in preventing avoidable complications associated with anemia during the third trimester.

Impact of Umbilical Cord Milking and Delayed Cord Clamping on Hematological Parameters in Term Neonates: A Case Control Study

Introduction Placental transfusion is additional volume of blood transferred to the baby during birth. A newborn who receives placental transfusion at birth obtains 30% more blood volume than the newborn whose cord is cut immediately. Receiving an adequate blood volume from placental transfusion at birth may be protective for the distressed neonates. It provides sufficient iron reserves for the first 3 to 6 months of life there by preventing or delaying iron deficiency anemia until the use of iron fortified food is implemented. There are 2 ways of placental transfusion, they are delayed cord clamping and umbilical cord milking. Delayed cord clamping (defined as clamping till cessation of pulsations or up to 60-180 s) leads to improvement in levels of hemoglobin and hematocrit at 6 weeks of age. However, universal application is limited due to concerns for the risk of hypothermia, and delay in initiation of resuscitation if required. Umbilical cord milking involves milking the entire contents of the umbilical cord towards the baby with in 20 s. Umbilical cord milking can be used in deliveries where delayed cord clamping is not feasible. Objective Comparison of hematological parameters (cord hemoglobin at birth, hemoglobin, hematocrit, and bilirubin levels in term neonates at 48 h with umbilical cord milking and delayed cord clamping). Methods and Analysis In this study all the term neonates delivered by vaginal delivery and lower segment caesarean section born to nonanemic mothers were considered eligible. All newborns with no risk factors underwent delayed cord clamping (n = 148) and those term neonates in whom delayed cord clamping was not feasible and/or currently WHO guidelines recommend for immediate cord clamping were allocated for umbilical cord milking (n = 121). Cord hemoglobin at birth, hemoglobin, hematocrit, and bilirubin (direct and indirect) were sent at 48 h. These parameters were compared between 2 groups. Results At birth cord hemoglobin was 15.36 and 15.46 (mean difference = 0.1) in DCC and UCM, respectively. At 48 hours, mean hemoglobin was 18.73 and 18.95 (mean difference = 0.22, P = .3591). Mean hematocrit was 52.22 and 53.28 (mean difference = 1.06, P = .0989), and mean total bilirubin levels was 11.24 and 10.56 (mean difference = 0.69, P = .466). Conclusion There were no statistically significant differences in the hematological parameters in full term neonates at 48 h, between delayed cord clamping and umbilical cord milking groups.

Anemia in pregnancy and sleep of 6-month-old infants: A prospective cohort study.

Anemia has been reported to adversely influence sleep in infants. However, the association between anemia in pregnancy and infant sleep remains unclear. We aimed to examine the association between maternal anemia in pregnancy and sleep parameters of 6-month-old infants. We enrolled 2,410 mother-infant pairs between 2018 and 2021 in Hefei. Data on maternal hemoglobin concentration were collected at 24-28 gestational weeks from the electronic medical records of the hospitals. Nocturnal and daytime sleep duration, number of night awakenings, nocturnal wakefulness, and sleep latency of infants aged 6 months were measured using the Brief Infant Sleep Questionnaire with five items. A restricted cubic spline model was used to examine the relationship between maternal hemoglobin concentration and infant nocturnal sleep duration after adjusting for potential confounders. In our study, 807 (33.5%) mothers had anemia during pregnancy. Compared to infants born to mothers without anemia, infants born to mothers with anemia in pregnancy had shorter nocturnal sleep duration [mean (SD), 560.29 (79.57) mins vs. 574.27 (75.36) mins] at the age of 6 months. Subgroup analysis showed consistent significant differences in nocturnal sleep duration between infant born to anemic and non-anemic mothers, except in case of stratification by preterm birth [mean difference (mins), 2.03 (95% CI, -20.01, -24.07)] and pre-pregnancy obesity [mean difference (mins), -0.85 (95% CI, -16.86, -15.16)]. A J-shaped nonlinear correlation curve was observed between maternal hemoglobin concentration and infant nocturnal sleep duration. Compared with mothers without daily iron supplementation, mothers who had daily iron supplementation had higher hemoglobin concentrations [mean (SD), 112.39 (11.33) g/L vs. 110.66 (10.65) g/L] at delivery and their infants had longer nocturnal sleep duration [mean (SD), 565.99 (82.46) mins vs. 553.66 (76.03) mins]. Anemia in pregnancy may have an adverse influence on the sleep of 6-mon-old infants, and the relationship between maternal hemoglobin concentration and nocturnal sleep duration is nonlinear.

Determination of hematological response to iron and folic acid supplementation among the expectant mothers attending Kakamega County Referral Hospital, Kenya

Background Despite iron and folic acid supplementation program among expectant mothers while attending antenatal care clinic at Kakamega County, the rates of maternal and fetal morbidity and mortality due to anemia complications are still high. Aim First, we determined changes in hematological profiles following iron and folic acid supplementation. Second, we determined association between hematological changes with demographic and clinical characteristics in response to iron and folic acid supplementation. Patients and methods Full hemogram and reticulocyte profiles of 127 expectant mothers were determined at baseline and endpoint after 1 month of iron and folic acid supplementation. Full hemogram profiles were measured using a Maxim 3010 fully automated hematology analyzer, whereas reticulocyte profiles were examined microscopically at ×100 magnification. Demographic data were collected using pretested structured questionnaires. Results The end point measures of red blood cells, hemoglobin (Hb), hematocrit, mean cell volume, reticulocyte count, reticulocyte production index, and absolute reticulocyte number among the anemic mothers were significantly higher relative to baseline levels. Among nonanemic mothers, Hb and mean cell volume levels differed significantly between baseline and end point of the study. The change in erythropoietic response and adequate Hb response was significantly associated with adherence to iron and folic acid supplement. Conclusion Hematological profiles significantly changed especially among anemic mothers following iron and folic acid supplementation. Adherence to supplement is associated with positive erythropoietic response and adequate Hb response.

Ratio of Placenta to Birth Weight in Anemic and Non-Anemic Mothers

Background: The placenta is a uterine organ in pregnancy which facilitates exchange of materials between maternal and fetal circulation. Decreased maternal hemoglobin decreases oxygen supplementation to fetus among anemic mothers which may cause low birth weight. The aim of this study was to compare the ratio of placenta to birth weight among anemic and non-anemic mothers.&#x0D; Materials and Methods: A comparative cross-sectional study was conducted in 82 anemic pregnancies and 203 non-anemic pregnancies in Department of Obstetrics &amp; Gynecology, Nobel Medical College Teaching Hospital, Biratnagar. Participants with haemoglobin concentration lower than 11 g/dl were included in anemic group and 11g/dl or more in non-anemic group. The difference of means of placental weight, birth weight and placenta to birth weight ratio in anemic and non-anemic groups was determined by Student’s t-test.&#x0D; Results: In anemic group, mean placental weight was 578.78±141.80 g, mean birth weight was 2973.17±680.97 g and mean placenta to birth weight ratio was 0.20±0.05. In non-anemic group, mean placental weight was 575.96±128.88 g, mean birth weight was 3125.91±590.89 g and mean placenta to birth weight ratio was 0.19±0.05. Significant difference was observed in means of placenta to birth ratio in anemic and non-anemic groups (p-value 0.05).&#x0D; Conclusion: Mean placental weight and mean ratio of placenta to birth weight was higher in pregnant women with anemia than in non-anemic pregnant women and significant difference was observed in means of placenta to birth ratio between anemic and non-anemic groups.

The Effect of Maternal Anemia on Low Birth Weight: Meta Analysis

Background: Low birth weight is still a global public health problem that is associated with a number of risks. One of the factors that influence the occurrence of LBW is anemia. This study was aimed to estimate the risk of anemia in pregnant women to the incidence of LBW in several countries.Subjects and Method: This study is a meta-analysis with PICO, Population: pregnant women. Intervention: maternal anemia. Comparison: no maternal anemia. Result: LBW. The articles used in this study were obtained from three databases namely Google Scholar, Pubmed, and Science Direct with a cohort study design from 2015 to 2022 that reported Adjusted Odds Odds Ratio in its multivariate analysis. The selection of articles was carried out using the PRISMA flow chart. Analysis of articles using the Review Manager 5.3 application.Results: A total of 9 cohort studies involving 75,807 pregnant women from Taiwan, China, Japan, India, Bangladesh, Iran, and Colombia were selected for systematic review and meta-analysis. The data collected showed that pregnant women who were anemic during pregnancy had a 1.3 times higher risk of giving birth to babies with low birth weight than non-anemic mothers, but this result was not statistically significant (aOR= 1.30; 95% CI= 0.89 to 1.88; p= 0.170). With an intuitive index of 84%, so the effect between the studies is heterogeneous.Conclusion: Mothers who experience anemia during pregnancy have a risk of giving birth to babies with low birth weight. Keywords: anemia, pregnancy, low birth weight Correspondence:Fahmi Adhimukti. Study Program of Midwifery, Diploma IV, Health Polytechnics, Ministry of Health Surakarta. Jl. Tata Bumi 3, Sleman, Yogyakarta, Indonesia. Email: fahmiadhimukti13@gmail.com. Mobile: 085743155133.

Maternal Anemia as a Risk Factor for Preterm Delivery and Low Birth Weight

Aim: Maternal anemia as a risk factor for preterm delivery and low birth weight Methods: A cross-sectional study using pregnant women as participants to screen for pregnancy endpoints and perform a hemoglobin test. A logistic regression model was used. The adjusted odds ratios and 95% confidence intervals were utilized in this investigation to determine if maternal anemia, preterm labor and low birth weight were associated. Results: The mean maternal age was 27.8±6.4 in anemic women and 28.2±5.9 in non-anemic women. Preterm birth was 26.3% in anemic women and 10% in women who were not anemic. Low birth weight babies accounted for 32.5% of the anemic group and 10% of non-anemic mothers gave birth to low birth weight babies. Conclusion: Pregnant mothers who were anemic had a greater chance of having a low birth weight babies. Keywords: Pregnancy, low birth weight, Labor

Effects of maternal iron deficiency anemia on placenta and cord blood iron status with specific reference to the iron transport protein ferroportin 1

Introduction: Iron deficiency anemia is the most prevalent nutritional deficiency disorder in pregnant women. During pregnancy, nutrients, including iron, are transferred from the mother to the fetus through the placenta, in which the placental transport protein Ferroportin1 (FPN1) plays a crucial role. It has been frequently observed that developing fetus is immune to anemia despite the presence of anemia in the mother, the mechanisms underlying which have not been identified. We, therefore, planned the present study to explore the effect of maternal iron deficiency anemia on the expression of FPN1 in the placenta. Material and Methods: Two hundred pregnant women recruited were divided into anemic and nonanemic groups based on their predelivery hemoglobin levels (<11 g/dl and ≥11 g/dl, respectively). After delivery, placental expression of FPN1 was studied by immunohistochemistry and mRNA analysis, and neonatal anthropometry was performed. Results: Of the 200 women, 59% were anemic. FPN1 protein immunohistochemical staining in placenta showed a statistically significant increase with increasing severity of anemia. Similarly, placental mRNA expression levels of the FPN1 gene were observed to be higher in anemic mothers when compared with nonanemic mothers. Discussion and Conclusion: Thus, our study for the first time shows that maternal iron deficiency increases placental FPN1 protein and mRNA expression, thereby probably facilitating increased transport of iron from the mother to the fetus.

Association between maternal anemia and poor pregnancy outcome in selected hospitals of Ujjain districts of the central part of India

Background: Anaemia is one of the most important factors influencing maternal morbidity and mortality and also the health of the newborn. It is a global health issue affecting nearly half of pregnant women. This study aimed to assess the association of maternal anemia with poor pregnancy outcomes.Methods: It was a cross-sectional study that included 2 study centers. As per inclusion/exclusion criteria, this study included 650 post-partum mothers. Using Stratified random sampling study participants were enrolled. Data were collected and analyzed in SPSS 23. Using statistical tests i.e., Chi-square, t-test, etc data was analyzed.Results: Anaemic mothers had a statistically significant association with low birth weight (χ2-9.099, p -0.003) and babies born dead (χ2-8.045, p -0.005). Using the student t-test, there was a significant mean birth weight difference of 114 gms of newborns among anemic and non-anemic mothers (p-0.003).Conclusions: Improving anemic status during pregnancy can reduce the burden of poor pregnancy outcomes.

Gestational Anemia and its effects on neonatal outcome, in the population of Hyderabad, Sindh, Pakistan

BackgroundAnemia in pregnancy is a globally health-related issue, that affects both mothers and their newborn. Anemia during pregnancy across the world involves approximately 38% of the world population. To evaluate the effect of gestational anemia on perinatal outcome in the population. The aim of present study is to evaluate the effect of gestational anemia on perinatal outcome in the population of Hyderabad, Sindh, Pakistan.MethodsA cross-sectional comparative analysis was conducted among pregnant mothers who were listed to give birth at Liaquat University of medical and health sciences Jamshoro/Hyderabad during the period of September 2018 to September 2019. The study population 400 were selected by convenient random sampling, and grouped into 2 on the basis of their Hb levels, with Hb < 11 gm% they were classified as anemic mothers, Hb ≥ 11 gm% were termed as non-anemic mothers, data was collected on the preformed questionnaire, and was analyzed on SPSS 21.ResultsThe prevalence of anemia was 51.5% in in total population out of which, the incidence of normocytic normochromic anemia was highest 52.4 %microcytic hypochromic anemia was found in 19.4%, Overall, extremely low Apgar was found in 53 anemics, and 8 non. anemic mother’s infants, LBW incidence was 47.5 %; in anemic mothers, and 15.4 % in non-anemic group, the term, small for gestational age infants were 14.5% in anemic mothers, and 3.6% in non-anemic mothers, there were 36 preterm births to anemic mothers and 10 in non-anemic mothers. The incidence of caesarian section is 53.3% in anemic mothers compared to 30.9% in non-anemic mothers.ConclusionsAnemia in pregnancy significantly increases risks of low Apgar, LBW, term SGA, preterm birth, and an increase incidence of caesarian section.

Maternal health status and household food security on determining childhood anemia in Bangladesh -a nationwide cross-sectional study

BackgroundThe aim of this study was to examine the effect of household food security on childhood anemia in Bangladesh while controlling for socioeconomic and demographic factors.MethodsWe used nationally representative Bangladesh Demographic Health Survey (BDHS) 2011 data for this study, the only existing survey including anemia information and household food security. The sample included 2171 children aged 6–59 months and their mothers. Differences between socioeconomic and demographic variables were analyzed using Chi-square test. Univariate and multivariate logistic regression analyses were performed to estimate the effects of different socioeconomic and demographic factors on childhood anemia. We also performed mediation analysis to examine the direct and indirect effect of household food security on childhood anemia.ResultsIn Bangladesh, 53% male (95% CI: 50–56) and 51% female (95% CI: 47–54) children aged 6–59 months were anemic in 2011. The food insecure households have 1.20 times odds (95% CI: 0.97–1.48) of having anemic children comparing to food secure households in the unadjusted model. On the other hand, anemic mothers have 2 times odds (95% CI: 1.67–2.44) of having anemic children comparing to non-anemic mothers. However, household food security is no longer significantly associated with childhood anemia in the adjusted model while mothers’ anemia remained a significant factor (OR 1.87: 95% CI: 1.53–2.29). Age of children is the highest associated factor, and the odds are 4.89 (95% CI: 3.21–7.45) for 6–12 months old children comparing to 49–59 months in the adjusted model. Stunting and household wealth are also a significant factor for childhood anemia. Although food security has no significant direct effect on childhood anemia, maternal anemia and childhood stunting mediated that relationship.ConclusionsFuture public health policies need to focus on improving mothers’ health with focusing on household food security to eliminate childhood anemia.

Trans-placental exchanges of serum iron, hemoglobin and ferritin at the end of gestation in the human species

This study relates to the determination of the concentrations of trans-placental exchanges of iron, hemoglobin and ferritin at the end of gestation according to the maternal martial status and the birth weight of the newborn. A total of 97 mother-newborn couples were included for this study in Algeria. Hemoglobin, iron and ferritin levels were measured in the maternal anticubital vein as well as in the umbilical vein after cord clamping. The mothers were classified into two groups, according to their hemoglobin and serum ferritin concentrations, into anemic and non-anemic mothers. Newborns were classified into three groups according to their birth weights: nnormotrophs, hypertrophes and hypotrophs. The prevalence of iron deficiency anemia in our women was 40.2%. All concentrations of trans-placental exchange of hemoglobin, iron and ferritin were positive; and no significant difference was observed in the mean values of exchange of the parameters studied between anemic and non-anemic mothers. The hemoglobin trans-placental exchange concentrations were significantly higher (P<0.001) and for ferritin were significantly lower (P<0.05) in hypotrophic neonates compared to normotrophs and hypertrophies; on the other hand for the iron were similar. Our results confirm the adaptive metabolic function of the placenta to ensure normal growth of the fetus.

STUDY OF MORPHOLOGY AND HISTOLOGY OF PLACENTA AND ITS CORRELATION WITH MATERNAL PARAMETERS AND BIRTH WEIGHT OF NEWBORN IN ANAEMIC MOTHERS

Abstract: The aim of this study was to determine whether maternal anaemia [Hb &lt;11gm/dl]would affect the morphology and histology of placenta and and correlate it with maternal parameters and birth weight of newborn and compare this with that of non-anaemic mothers. It was a cross-sectional comparative study carried out at the maternity ward and anatomy department of NSCB MEDICAL COLLEGE JABALPUR. Background &amp; Method: Background &amp; Method: The study was carried out on 100 placentae, mothers and their babies. The placenta was collected from Obstetrics and Gynaecology, Department of NSCB Medical College, Jabalpur. Out of 100 placentae 50 from anaemic and 50 from NON anaemic mothers. &#x0D; As soon as the placenta was delivered, the umblical cord was cut it was put into formal saline. It was kept in a tray, to the membranes were trimmed off cord was cut about 10 cm from the insertion. The blood clots adherent to maternal surface were picked up. Morphological parameters like placental weight, volume. diameter, thickness, no of cotyledons were measured .Any abnormality like calcification, accessory lobe, haematoma, etc were noted. histological slides were made and stained with H and stain and Masson’s Trichrome stain. Result: A Macroscopic study of the placenta revealed placental weight, placental volume, diameter, placental thickness were more than non anaemic group and number of cotyledons were less in study group. Mean placental weight in study group was 474gm and in control group was 425 (p&lt;0.05). Mean placental volume in study group &amp; control group were 393.23and352 ml respectively (p&lt;0.05). Mean number of cotyledons were 13.24and 16 in study &amp; control group significant[p&lt;0.05] and mean diameter 18.30cms and17.05cms in study and control group. Mean placental thickness 2.4cms in study and 2.1 in control group respectively. There was an accessory lobe present in one patient of anaemic group. All morphometric parameters of placenta weight, volume, diameter, thickness were increased ,no of cotyledons were reduced .Histological findings were placental tissues shows intense congestion of septal capillaries.In the present study age, parity, height, weight, built, doesn’t found to be related with morphology of placenta. Maternal blood Hb found to be +vely correlated with weight, volume, diameter, thickness and –vely correlated with no of cotyledons and birth weight of baby. Conclusion: From the study it is concluded anaemia in pregnancy affects morphology and histology of placenta and it is correlated with various maternal parameters and birth weight of baby.&#x0D; Keywords: morphology, histology, placenta, anaemia, birth weight &amp; mothers.

Effect of maternal anemia on breast milk iron status

Objectives: Nutritional anemia is highly prevalent in lactating mothers. It is postulated that anemic pregnant women secrete less iron in their breast milk. This study was aimed to compare the iron levels in breast milk samples of anemic and non-anemic lactating pregnant women and to correlate breast milk iron levels with the hemoglobin (Hb) status of anemic and non-anemic mothers. Materials and Methods: A case–control study was conducted on 120 pregnant women aged 20–30 years having a normal antenatal history. They were classified into non-anemic and anemic groups based on their Hb status; Group 1: Hb ≥11 g/dl and Group 2: Hb 7–10.9 g/dl, respectively. Results: Maternal blood Hb was significantly different between the groups (11.8 ± 0.6 vs. 10.2 ± 0.5 g/dL, P &gt; 0.05). Breast milk iron levels did not vary significantly between the groups (938.8 ± 465.6 vs. 1084.8 ± 440.8 μg/dl). No correlation was observed between maternal Hb levels of anemic lactating mothers and breast milk iron status (r = 0.054, P = 0.424). Conclusion: Our research study validates the finding that maternal anemia did not affect breast milk iron concentration during the early post-natal period by showing the optimum iron levels in it. Therefore, exclusive breastfeeding is the ideal nutrition for infants.