Acne Research Articles

Targeted precision cryotherapy for acne vulgaris.

Acne vulgaris poses a significant dermatological challenge, necessitating alternative treatments due to limitations and side effects associated with current therapies. This pilot clinical trial investigated the feasibility and efficacy of precision cryotherapy for acne vulgaris. A total of 20 volunteers underwent targeted precision cryotherapy using a carbon dioxide-based device. Treatment outcomes were assessed using various parameters, including Investigator Global Assessment (IGA) score, acne lesion count, erythema index (EI), global evaluation score, and participant satisfaction. Safety monitoring included adverse event reporting and physical examination. Precision cryotherapy demonstrated a significant reduction (90.25%) in the acne lesion count by week 4, with clinical improvement indicated by IGA score reduction (p<0.001). The EI showed notable improvements at weeks 1, 2, and 4. The global evaluation score demonstrated a 75%-100% clinical improvement at Visit 4. Participants reported high satisfaction (6.75±0.79) with the procedure. No adverse event or discomfort was reported. Precision cryotherapy effectively improved acne lesions, which was safe and satisfactory for participants. These findings suggest its potential as an alternative therapeutic modality, especially for populations with limited treatment options. Further research is needed to validate the results and explore underlying mechanisms.

53899 Treatment success with sarecycline for treatment of acne vulgaris (AV): Comparison of results from randomized controlled trials (RCTs) and the real-world (RW) PROSES study

53899 Treatment success with sarecycline for treatment of acne vulgaris (AV): Comparison of results from randomized controlled trials (RCTs) and the real-world (RW) PROSES study

54052 Safety of sarecycline for treatment of acne vulgaris (AV): Real-world results from the PROSES study

54052 Safety of sarecycline for treatment of acne vulgaris (AV): Real-world results from the PROSES study

50810 Beyond the Face: Treatment of Truncal Acne with Daily Use Regimen of OTC Exfoliating Cleanser and Soothing Body Moisturizer

50810 Beyond the Face: Treatment of Truncal Acne with Daily Use Regimen of OTC Exfoliating Cleanser and Soothing Body Moisturizer

51688 Acne Diagnosis and Treatment Patterns in Underrepresented Groups: An All of Us Database Analysis

51688 Acne Diagnosis and Treatment Patterns in Underrepresented Groups: An All of Us Database Analysis

Impact of Isotretinoin on Blood Lipids and Liver Enzymes: A Retrospective Cohort Study in Saudi Arabia.

Isotretinoin is an effective treatment for acne but can cause side effects such as changes in blood lipids and liver enzymes. Laboratory monitoring is essential during treatment, but there is variation in monitoring practices. This study aims to investigate the relationship between isotretinoin therapy and its effects on complete blood count in Saudi Arabia to improve patient outcomes. The study was a retrospective cohort study conducted at King Khalid University Hospital in Riyadh, Saudi Arabia, between January 2016 and December 2020. Following the inclusion and exclusion criteria, 515 patients were randomly selected for the study. The data was analyzed using SPSS, and descriptive statistics and paired samples t-tests were employed to analyze the data. In this study, 515 patients were enrolled. Of these participants, 76.7% (n=395) were females and 23.3% (n=120) were males. The mean age of the study participants was 23.98±7.4 years and ranged between 16 and 65 years. The mean dose of Isotretinoin administered was 27.65±9.6 mg/day, with a range of 10-60 mg/day. The mean BMI of the study participants was 24.3±4.1 kg/m2, ranging from 14.3 to 44.8 kg/m2. Regarding the effect of Isotretinoin on laboratory measures, significant statistical differences were found in hemoglobin measurements (t=-3.379, p=0.001), platelets (t=-3.169, p=0.002), neutrophils (%) (t=3.107, p=0.002), total cholesterol (t=-13.017, p=0.000), AST (t=-6.353, p=0.000), ALT (t=-4.352, p=0.000), HDL (t=2.446, p=0.015), and LDL (t=-12.943, p=0.000). However, there were no significant statistical differences in the measurements of WBC, neutrophils (count), or triglycerides. In the Chi-square analysis and Fisher's Exact test to identify the interaction between BMI, dose, and gender on abnormal lab results, significant interaction was found between participants' BMI and abnormal HDL measurements (p=0.006). Furthermore, there were significant interactions between Isotretinoin dose (either less than 30 mg/day or 30 mg/day or more) and abnormal neutrophil count (p=0.04), abnormal HDL measurements (p=0.010), and abnormal triglycerides measurements (p=0.020). Moreover, a statistically significant interaction was found between participants' gender and abnormal hemoglobin measurements (p=0.006), abnormal total cholesterol (p=0.016), abnormal AST measurements (p=0.001), abnormal ALT measurements (p=0.000), abnormal HDL measurements (p=0.000), and abnormal triglycerides measurements (p=0.007). In conclusion, the study found that isotretinoin therapy has significant effects on several laboratory measures, including hemoglobin, platelets, neutrophils, total cholesterol, AST, ALT, HDL, and LDL. The study also revealed significant interactions between BMI, dose, gender, and abnormal lab results.

50905 Gastrointestinal comorbidities of acne vulgaris in Taiwan: a 13-year population-based retrospective study

50905 Gastrointestinal comorbidities of acne vulgaris in Taiwan: a 13-year population-based retrospective study

53728 Reflectance confocal microscopy and clinical evaluation of a product containing Silybum marianum fruit extract (SMFE) in monotherapy for acne vulgaris treatment: a prospective study

53728 Reflectance confocal microscopy and clinical evaluation of a product containing Silybum marianum fruit extract (SMFE) in monotherapy for acne vulgaris treatment: a prospective study

52036 Comparative Study on the Effectiveness and Safety of 0.13% CBD Acne Cream with 2.5% Benzoyl Peroxide versus 1% Standardized Clindamycin Gel with 2.5% Benzoyl Peroxide for the Treatment of Acne Vulgaris: A Randomized Controlled Trial

52036 Comparative Study on the Effectiveness and Safety of 0.13% CBD Acne Cream with 2.5% Benzoyl Peroxide versus 1% Standardized Clindamycin Gel with 2.5% Benzoyl Peroxide for the Treatment of Acne Vulgaris: A Randomized Controlled Trial

49342 First FASN inhibitor ASC40 to treat acne vulgaris patients: final results form a Phase 2 trial

49342 First FASN inhibitor ASC40 to treat acne vulgaris patients: final results form a Phase 2 trial

Should Serum Levels of Creatine Kinase be Evaluated in Patients with Acne Vulgaris Treated with Systemic Isotretinoin

The laboratory tests that should be performed and their frequency during isotretinoin treatment are controversial. We wanted to investigate muscle and joint pain and laboratory tests in acne patients who received isotretinoin. Between April 2019 and February 2023, serum CK, AST, ALT, and GGT levels were retrospectively evaluated in acne patients before and three months after systemic isotretinoin treatment. This study included 410 patients. The median serum AST, ALT, and GGT levels significantly increased, whereas serum CK levels were similar in all patients three months after treatment. 23 (5.6%) patients revealed muscle or joint pain after treatment. No significant difference was detected in patients with or without pain in the median serum CK, AST, ALT, and GGT levels after treatment. Isotretinoin treatment at a dose of 10 mg/day was more common in patients with pain than in those without pain, whereas none of the patients who received isotretinoin 40 mg/day developed muscle or joint pain. We suggest that routine evaluation of serum CK levels is unnecessary in acne patients treated with isotretinoin. However, muscle and joint pain may develop even at doses as low as 10 mg/day. Furthermore, monitoring AST, ALT, and GGT levels may be beneficial in acne patients treated with isotretinoin.

54413 Efficacy of a dermocosmetic cream compared to benzoyl peroxide gel on acne vulgaris treatment

54413 Efficacy of a dermocosmetic cream compared to benzoyl peroxide gel on acne vulgaris treatment

53944 Facial Distribution Patterns in Tyrosine Kinase Inhibitor-Induced Acneiform Eruption versus Acne Vulgaris: A Retrospective Study in a Taiwanese Tertiary Medical Center

53944 Facial Distribution Patterns in Tyrosine Kinase Inhibitor-Induced Acneiform Eruption versus Acne Vulgaris: A Retrospective Study in a Taiwanese Tertiary Medical Center

49157 Acne vulgaris in black pediatric patients: clinical presentation, treatment patterns, and unique needs

49157 Acne vulgaris in black pediatric patients: clinical presentation, treatment patterns, and unique needs

54092 The Development of Treatment Guidelines for Acne Vulgaris During Pregnancy and Lactation: A Delphi Consensus Study

54092 The Development of Treatment Guidelines for Acne Vulgaris During Pregnancy and Lactation: A Delphi Consensus Study

51725 Importance of a tailored skin care routine for patients with moderate acne vulgaris and post-inflammatory hyperpigmentation treated with topical trifarotene

51725 Importance of a tailored skin care routine for patients with moderate acne vulgaris and post-inflammatory hyperpigmentation treated with topical trifarotene

53923 Efficacy of a dermocosmetic acne treatment in reducing post-inflammatory hyperpigmentation in subjects with phototypes IV to VI

53923 Efficacy of a dermocosmetic acne treatment in reducing post-inflammatory hyperpigmentation in subjects with phototypes IV to VI

Assessment of disability index and dermatological life quality among acne vulgaris patients attending tertiary care centre in south India: A Cross Sectional Study

Background: Individuals with Acne vulgaris experience significant psychological and social disability, struggling with self-consciousness and personal relationships. Aim &amp; Objective: to determine the psychological influence of acne on QOL (quality of life) of adolescents in both rural and urban areas. Settings and Design: tertiary care hospital and cross-sectional study design Methods and Material: Total 229 study participants were selected using a purposive sampling method from the Dermatology OPD. A pretested semi-structured questionnaire was used as the study tool, which included CADI, DLQI. Data was collected by interviewing the study participants. Statistical analysis used: Descriptive statistics and kruskal wallis test were applied Results: Most common type of acne was facial acne observed in 88.7% of study participants. The majority fell into the low-grade category of the CADI, comprising 53.04% of the study participants. 25.65% reported a very large effect on their life as indicated by the DLQI grades

The History and Current Status of Platelet-Rich Plasma Therapy in Dermatology.

Since the 1800s, platelet-rich plasma (PRP) has been used as a treatment for a wide range of medical conditions with a concomitant effect of tending to reduce the need for some invasive procedures. The aim of this narrative review was to concisely document the history and current usage of PRP specifically in the field of dermatology. Four databases (PubMed, Google Scholar, CINAHL, and Web of Science) were searched for primary articles written in English that evaluated human subjects and focused on PRP use in dermatology. Initial search terms included "platelet rich plasma,""alopecia,""androgenic alopecia,""dermatology,""PDGF,""aging,""skin rejuvenation,""diabetic ulcers,""venous leg ulcers," "acne,""acne scars,""scars,""hyperpigmentation,""melasma,""hypopigmentation,""vitiligo,"and "PRP."After review, articles were excluded if they were commentaries, editorials, animal studies, review articles, or were unrelated to dermatology. The bibliography of retrieved articles was also searched for relevant articles.The present review results describe the function of PRP from its first usage for thrombocytopenia to its usage for melasma. In this time frame, its use in dermatology has gone through many evolutions from using its healing factors for treating wounds to using it as the treatment for wrinkles, hair loss, scars, ulcers, and skin pigmentation disorders. Its anti-inflammatory and growth factors have been shown to initiate a healing cascade that promotes the growth and regeneration of tissues. It is hoped that this review will help educate patients and physicians about the efficacy of PRP therapy and thereby help avoid unnecessary invasive procedures for certain conditions.

Relationship between acne vulgaris and attention deficit hyperactivity disorder in adolescent: A cross-sectional study.

High androgen hormone exposure in intrauterine life is held to be responsible for the etiopathogenesis of both acne vulgaris (AV) and attention-deficit hyperactivity disorder (ADHD). In this study, we aimed to investigate the prevalence of ADHD in AV patients. Patients between the ages of 12 and 17, diagnosed with AV and a control group were included in the study. The Conners-Wells Adolescent Self-Report Scale-Long Form (CASS-L) was applied to both groups to determine the severity of the ADHD. Ninety-eight patients diagnosed with AV and 96 healthy controls participated in the study. All parameters of the CASS-L were found to be significantly higher in AV patients compared to the control group. In addition, with the severity of the Global Acne Grading System, a positive low level among conduct problems (r = 0.223), cognitive problems (r = 0.271), ADHD index (r = 0.238), inattention (r = 0.238), and a positive moderate level among hyperactivity (r = 0.349), hyperactivity-impulsivity (r = 0.414), and total score (r = 0.429). According to our results, patients diagnosed with AV were more prone to ADHD than the control group. Our study showed that adolescent patients diagnosed with AV were more prone to ADHD than people of similar age and gender without a diagnosis of AV. It should be noted that AV is not only a dermatological disease but may also be accompanied by psychiatric morbidities.