Nodular Lymphocyte Predominance Research Articles

Hodgkin's disease stage I and II.A comparison between two different treatment policies

A retrospective analysis was performed on 145 patients with Stage I and II Hodgkin's disease treated over an 11-year period. Sixty-two patients (Group I) received a mantle field without systematic irradiation of the para-aortic lymph nodes. Eight-three patients (Group II) received radiotherapy according to the folowing policy: all Stage IB and IIB and all mixed cellularity and lymphocytic depletion types received total nodal irradiation while stage IA and IIA nodular sclerosing and lymphocytic predominance cases received irradiation to a mantle field and to the para-aortic lymph nodes. The characteristics of the two groups were roughly comparable in age range, sex, staging, histopathologic subtypes and total irradiation doses. All patients had lymphangiograms although not all underwent staging laparotomies. The staging laparotomy did not appear to have an influence within each group. The extent of irradiation did significantly affect both the incidence of further manifestation of disease as well as survival rates. The frequency of lymph node extension, organ extension and local recurrence for Group I was 24%, 14%, and 3%, while for Group II it was 4%, 6%, and 6%, respectively. The seven-year absolute survival rate for Group I was 57% while for Group II it was 93%.

A case control study on immunity to two epstein‐barr virus‐associated antigens, and to herpes simplex virus and adenovirus in a population‐based group of patients with hodgkin's disease in denmark, 1971–73

One hundred and eighty-five patients with untreated Hodgkin's disease (HD) comprising 86% of all new cases diagnosed in Denmark over a 2-year period, were individually matched with healthy controls of the same age, sex, and social class. In comparison to controls, HD patients showed significantly elevated mean antibody titres to Epstein-Barr viral capsid antierences in mean titres were found for adenovirus common antigen. Subdivision of the patients by age, sex, social class, HL-A antigens, stage of disease and histology did not alter this pattern, except that significant case-control differences in EB-VCA titres could be demonstrated only for the nodular sclerosis and lymphocyte predominance subgroups. After 1 year of treatment, a significant rise in EB-VCA mean titre had taken place. Splenectomy seemed to promote this titre elevation. Neither the initial titres to EB-VCA and EBV-EA nor changes in titres over time were related to prognosis. The results of our study, which are more representative of a population of HD patients and controls than previously reported studies, confirm that the reported relationship between EBV and HD exists, but that the elevated EBV titres are probably not of etiologic significance in most HD patients.

Relationship of Visceral Lesions and Histological Type in Hodgkin's Disease

60 autopsies of patients with Hodgkin's disease (HD) were studied. In 53 cases one histological type of HD was found. Mixed cellularity HD was present in 36 cases, lymphocytic depletion in 13 and lymphocytic predominance and nodular sclerosing HD in 2 cases each. HD was confined in almost all cases to the lymph nodes, spleen, liver and lungs. The liver involvement was much more common in mixed cellularity HD that in the cases with lymphocytic depletion, and the reverse was true of the lung lesions. Six cases showed vein invasion by HD in the lymph nodes, spleen and liver. The cases with lymphocytic depletion HD died mainly of their tumor. In cases with mixed cellularity, HD as a cause of death was as frequent as death from other causes, mainly bacterial infections. In the few cases with nodular sclerosis and lymphocytic predominance, HD was not directly responsible for the death of the patients. In only four of the 60 cases, two histological types of HD were found in the different organs, and in three cases no HD was present at autopsy. Our findings show differences in the frequency of organ involvement and the cause of death between the histological varieties of HD. In almost all cases only one type of HD was found at autopsy confirming previous results in tissue obtained at laparotomies performed in the course of the initial evaluation of a patient with HD. In dieser Arbeit werden die Obduktionen von 60 Patienten, die an einem Morbus HODGKIN erkrankt waren, ausgewertet. Bei 53 Fällen konnte die Erkrankung auch noch an der Leiche nachgewiesen werden. Unter Berücksichtigung der verschiedenen HODGKIN-Formen (36 gemischte, 13 lymphozytenarme, 2 lymphozytenreiche und 2 nodulär-sklerosierende) werden die allgemeine Häufigkeitsverteilung, Organbefall (Lymphknoten, Milz, Leber und Lungen) sowie die Todesursachen untersucht. Patienten mit einem M. HODGKIN vom lmphozytenarmen Typ waren vorwiegend an ihrem Grundleiden gestorben, während Patienten mit einer lymphozytenreichen oder einer nodulär-sklerosierenden Form an den Folgen einer komplizierenden bakteriellen Erkrankung starben. Weiter konnte festgestellt werden, daß bei 4 Fällen 2 oder 3 verschiedene HODGKIN-Formen gleichzeitig vorlagen. An Hand dieses Obduktionsmaterials kann festgestellt werden, daß beim M. HODGKIN Abweichungen in der Organlokalisation und im klinischen Verlauf vorkommen, die von dem histologischen Typ der Erkrankung abhängig sind.