We reviewed the records of 68 consecutive patients with localized or locally advanced prostate carcinoma treated with definitive radiation from 1959 through 1970. In patients followed over 5 years, the lymphatics within the true pelvis received at least 5000 rads in 5 to 6 1/2 weeks, and the primary received 6000 to 7500 rads in 7 to 11 weeks. There were 64% 5-year and 38% 10-year actuarial survivals, and clinical local control in 91% of the 5- to 12-year survivors (21/23). Additionally, negative prostate biopsies were obtained in 76% of the patients sampled more than 1-year after treatment (16/21). This report offers further evidence that carcinoma of the prostate, even if inoperable, is curable with radiation, but we could not demonstrate an improvement in 5-year survival, 10-year survival, or disease-free rate with pelvic nodal treatment.