For pupil-offset off-axis reflective astronomical telescopes with designed tilts and decenters, owing to the absence of symmetry, axial and lateral misalignments exhibit strong coupling. The astigmatic and coma aberration fields of the misaligned optical systems are not only effected by lateral misalignments but also closely related to axial misalignments. However, the traditional misalignment algorithm based on nodal aberration theory (NAT) usually ignore the effect of axial misalignments on the aberration fields of optical systems when constructing calculation models. As a result, the presence of axial misalignments in pupil-offset off-axis telescopes with designed tilts and decenters will invalidate the traditional NAT-based lateral misalignment algorithm, which makes it difficult to be applied to actual computer-aided alignment experiments. In order to solve this issue, on the framework of modified NAT, third-order astigmatic, third-order coma, and third-order spherical net aberration fields of pupil-offset off-axis systems with designed tilts and decenters induced by axial and lateral misalignments are separated from the total aberration fields, and their inherent relations are analytically expressed. On this basis, in order to construct a solution model that can simultaneously and quantitatively calculate the axial and lateral misalignments, a method is proposed to fit the partial derivative coefficient matrix of misalignments according to field dependence of the net aberrations induced by misalignments. The simulation and actual alignment experiments were performed on a real wide-field off-axis three-mirror telescope using the constructed solution model, which proved the feasibility of the proposed method. Simulation experiments show that for different misalignment conditions generated randomly, both axial and lateral misalignments have achieved convergent solution results. In the actual alignment experiment, the average RMS wavefront errors of the nine field of views is corrected from 1.9 λ to 0.12 λ (λ = 632.8nm) through 3-5 iterations.
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