In this study, we synthesized the new 2,4,6-triaryl pyridine by reacting alkoxy chalcone with ammonium acetate, followed by extensive characterization utilizing a variety of spectral techniques such as FT-IR, NMR, Mass, and X-ray analysis. In addition, a comparison was made between the compound's X-ray structure and its optimized molecular structure based on bond lengths and angles. Furthermore, theoretical investigations were conducted to elucidate the physical properties of both the starting compounds and the produced compound and to study their electrochemical behavior to understand their oxidation and reduction processes. The ADME analysis showed the insolubility of these compounds and directed us to use them in insecticidal activities on two insect species, Plodia interpunctella, and Nilaparvata lugens. The results showed efficacy comparable to the Thiamethoxam drug and these biological results were confirmed with molecular docking simulation on different proteins.