This paper studies the microstructure, phase composition and tribological response of BT22 bimodal titanium alloy samples, which were selectively laser-processed before nitriding. Laser power was selected to obtain a maximum temperature just a little above the α↔β transus point. This allows for the formation of a nano-fine cell-type microstructure. The average grain size of the nitrided layer obtained in this study was 300-400 nm, and 30-100 nm for some smaller cells. The width of the "microchannels" between some of them was 2-5 nm. This microstructure was detected on both the intact surface and the wear track. XRD tests proved the prevailing formation of Ti2N. The thickness of the nitride layer was 15-20 μm between the laser spots, and 50 μm below them, with a maximum surface hardness of 1190 HV0.01. Microstructure analyses revealed nitrogen diffusion along the grain boundaries. Tribological studies were performed using a PoD tribometer in dry sliding conditions, with a counterpart fabricated from untreated titanium alloy BT22. The comparative wear test indicates the superiority of the laser+nitrided alloy over the one that was only nitrided: the weight loss was 28% lower, with a 16% decrease in the coefficient of friction. The predominant wear mechanism of the nitrided sample was determined to be micro-abrasive wear accompanied by delamination, while that of the laser+nitrided sample was micro-abrasive wear. The cellular microstructure of the nitrided layer obtained after the combined laser-thermochemical processing helps to withstand substrate deformations and provide better wear-resistance.