We present and discuss a set of data, mainly swath bathymetry, backscatter images and a few seismic data, that have been recently recorded over large areas of the Nile deep-sea fan between water depths of 1200 and 3000 m. These data demonstrate the presence of at least three distinct morphostructural provinces where interacting sedimentary, tectonic, and salt tectonic processes control the present day morphology and the recent evolution of the major Mediterranean deep-sea fan. The role of the ongoing collision presently occurring between the continental Eratosthenes Seamount and the Cyprus Arc may have been, and still is, a determining parameter for the development of the Nile deep-sea fan.