You have accessJournal of UrologyGeneral & Epidemiological Trends & Socioeconomics: Evidence-based Medicine & Outcomes I1 Apr 20103 MORTALITY IN THE ELDERLY CORRELATES WITH THE FREQUENCY OF NIGHTTIME VOIDING: RESULTS OF A 5-YEAR PROSPECTIVE COHORT STUDY IN JAPAN Haruo Nakagawa, Kaijun Niu, Yasuhiro Kaiho, Yoshihiro Ikeda, and Yoichi Arai Haruo NakagawaHaruo Nakagawa Sendai, Japan More articles by this author , Kaijun NiuKaijun Niu Aendai, Japan More articles by this author , Yasuhiro KaihoYasuhiro Kaiho Sendai, Japan More articles by this author , Yoshihiro IkedaYoshihiro Ikeda Sendai, Japan More articles by this author , and Yoichi AraiYoichi Arai Sendai, Japan More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.046AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Nocturia is a common problem that increases with age. It is often the result of an overproduction of urine at night (nocturnal polyuria), but may also be associated with several pathophysiological conditions, such as cardiovascular disease, diabetes mellitus, sleep apnea syndrome, renal dysfunction, lower urinary tract dysfunction and sleep disorders. An increased mortality rate has been reported with nocturia, and may be related to these associated conditions, or independently to nocturia. This study aimed to evaluate the association between night time frequency and mortality in a community-based elderly population. METHODS We conducted a Comprehensive Geriatric Assessment of all residents aged ≥70 years in 2003 in an urban district of north Japan. The population-based cross-sectional survey was conducted using an extensive health interview for each participant. Mortality was investigated using data from the national health insurance system over 5 years. Differences in survival stratified by the night time frequency of urination were assessed with Kaplan-Meier curves. Hazard ratios (HRs) were estimated from multivariate Cox proportional hazard models. RESULTS Seven hundred and eighty-eight subjects were included in the study (28.9% participation rate; 429 females, 359 males; mean age 76.0 years: range: 70-97 years). Kaplan-Meier curves representing mortality are shown in Figure 1. After multivariable adjustment, the HRs (95% confidence intervals) for mortality were 1.59 (0.80-3.17), 2.34 (1.09-5.00) and 3.60 (1.38-9.35) for people who voided 2, 3 and ≥4 times/night compared with ≤1 per night (p-value for trend <0.01: Table 1). The number of nighttime voiding episodes was associated with a significantly increased mortality. CONCLUSIONS We conclude that there is a significantly increased mortality associated with the nighttime frequency of urination, even after adjustment for several factors that could contribute to mortality. © 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e1-e2 Peer Review Report Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Haruo Nakagawa Sendai, Japan More articles by this author Kaijun Niu Aendai, Japan More articles by this author Yasuhiro Kaiho Sendai, Japan More articles by this author Yoshihiro Ikeda Sendai, Japan More articles by this author Yoichi Arai Sendai, Japan More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...