Nifedipine Sustained-release Tablets Research Articles

Analysis of a Study of Nifedipine Sustained-release Tablets Combined with Magnesium Sulfate in the Treatment of Hypertension during Pregnancy

Analysis of a Study of Nifedipine Sustained-release Tablets Combined with Magnesium Sulfate in the Treatment of Hypertension during Pregnancy

Clinical Observation on the Treatment of Hypertension by Combination of Modified Banxia Baizhu Tianma Decoction and Auricular Acupuncture

Objective: To observe the curative effect of Jiawei Banxia Baizhu Tianma Decoction (BBTD) in combination with auricular acupuncture in the treatment of primary hypertension with phlegm-dampness syndrome. Methods: 120 patients with hypertension were randomly divided into a pure Western medicine treatment control group (referred to as the control group) and an integrated traditional Chinese and Western medicine treatment group (referred to as the treatment group), with 60 cases in each group. The control group was given nifedipine sustained-release tablets orally; the treatment group: nifedipine sustained-release tablets were given on the basis of modified BBTD combined with auricular acupuncture. The treatment course duration of the two groups was 4 weeks. Before and after treatment, the two groups were evaluated for treatment efficacy and quality of life. Results: There is statistically significant difference in blood pressure lowering between the treatment group and the control group (P?0.05); the treatment group was better than the control group in symptoms improvement of the patients (P?0.05); in terms of the improvement in quality of life , the treatment group was significantly better than the control group (P?0.05, P?0.01). Conclusion: Modified BBTD combined with auricular acupuncture method can reduce blood pressure and improve clinical symptoms in patients with primary hypertension with phlegm-dampness syndrome, and significantly improve the quality of life of patients.

Clinical Effect of Nifedipine Sustained-release Tablets Combined with Enalapril in the Treatment of Elderly Patients with Coronary Heart Disease and Hypertension

Clinical Effect of Nifedipine Sustained-release Tablets Combined with Enalapril in the Treatment of Elderly Patients with Coronary Heart Disease and Hypertension

Cost-effectiveness analysis of combining traditional Chinese medicine in the treatment of hypertension: compound Apocynum tablets combined with Nifedipine sustained-release tablets vs Nifedipine sustained-release tablets alone

BackgroundWe evaluated the long-term cost-effectiveness of antihypertensive traditional Chinese medicines (TCMs) and to compare the cost-effectiveness of a combined treatment consisting of compound Apocynum tablets and Nifedipine sustained-release tablets with the cost-effectiveness of treatment with Nifedipine sustained-release tablets alone.MethodsA Markov model was used to simulate the potential incremental cost-effectiveness per quality-adjusted life year (QALY) to be gained from compound Apocynum tablets and Nifedipine sustained-release tablets compared with Nifedipine sustained-release tablets alone. Model parameter estimates were informed by previously published studies. The direct medical costs of outpatients with hypertension were estimated from the health care provider’s perspective. A 5% annual discount rate was applied to both costs and QALYs.ResultsTCMs combined with Nifedipine sustained-release tablets group generated a total 20-year cost of 11,517.94 RMB (US $1739.87), whereas Nifedipine sustained-release tablets alone group resulted in a 20-year cost of 7253.71 RMB (US $1095.73). TCMs combined with Nifedipine sustained-release tablets group resulted in a generation of 12.69 QALYs, whereas Nifedipine sustained-release tablets alone group resulted in 12.50. The incremental cost-utility ratio was 22,443.32 RMB (US $3390.23) per QALY. Considering the threshold of 1 GDP per capita in China in 2018 (US $9764.95), the combination of compound Apocynum tablets and Nifedipine sustained-release tablets was a cost-effective strategy. One-way and probabilistic sensitivity analysis showed unchanged results over an acceptable range.ConclusionsCombining Traditional Chinese Medicines with chemical medicines is more cost-effective strategy in the treatment of hypertension.

Ethylene Vinyl Acetate Microcapsules of Nifedipine: Characterization, Release Kinetics and Pharmacokinetic Evaluation

Microcapsules ethylene vinyl acetate with nifedipine as the core were prepared by the method of emulsion solvent evaporation and studied. Microcapsules were free flowing discrete, spherical, types of multi nuclear matrix and monolithic. The efficiency of microencapsulation was of the order of 93-99 %. Differential calorimetry studies scanning and infrared spectroscopy indicates that there is no interaction between the coating, vinyl acetate and ethylene and the base nifedipine. The release rate of nifedipine from the microcapsules was very slow and depends on the coat: core ratio, the wall thickness and the size of the microcapsules. Release was controlled by diffusion mechanism and followed first order kinetics. A good linear relationship was observed between the wall thickness of the microcapsules and the drug release rate and the 50 % release time value. The amount of nifedipine release in microcapsule MC 1 (Size 20/35) was close to the required theoretical sustained release amount and also meets the official release rate specification of nifedipine sustained release tablets (United States Pharmacopoeia XXIV). Nifedipine soft capsules were quickly absorbed after administration. The absorption of nifedipine in ethylene vinyl acetate microcapsules was slower and lasts for up to 8-10 h. For ethylene vinyl acetate microcapsules, the serum nifedipine concentration was stable and maintained in a narrow range (28-43 ng/ml) for a longer period of time (1-10 h). Using ethylene vinyl acetate microcapsules, the average residence time increased from 3.34 h for soft capsules to 7.05 h. Compared with soft capsules (100 %), the relative bioavailability of ethylene vinyl acetate microcapsules was 91.5 %.

PCV56 COST- EFFECTIVENSS ANALYSIS OF COMBINING TRANDITIONAL CHINESE MEDICINE IN THE TREATMENT OF HYPERTENSION

To explore pharmacoeconomic model based on blood pressure variability to simulate the long-term economic outcomes of antihypertensive Traditional Chinese Medicines (TCMs); and compare the cost-effectiveness of combining treatment of the compound apocynum tablets and nifedipine sustained-release tablets with nifedipine sustained-release tablets alone. A Markov model was constructed based on disease progression of hypertension. Clinical studies which measured blood pressure variability as primary outcomes were collected to extract essential clinical parameters and calculate transition probability. QALYs of each state were extract from literatures. Direct medical costs of outpatients of hypertension were estimated from health care provider's perspective. A 5% yearly discount rate was applied to both costs and QALYs. The expected mean cost and quality-adjust life-years were, respectively, 10096 RMB(US $1525.51) and 12.09QALYs for patients receiving TCM combining treatment and 7599 RMB(US $1148.21) and 11.92QALYs for those receiving nifedipine sustained-release tablets alone. The incremental cost-utility ratio was 14688.24 RMB(US $2219.41) per QALY. Considering the threshold of 1 GDP per capita in China in 2017(US $9014.63), the combination of compound apocynum tablets and nifedipine sustained release tablets was a cost-effective strategy. The univariate sensitivity analysis was performed to evaluate the robustness of the results. Using appropriate clinical indicators such as blood pressure variability as model parameters, long-term economics evaluation shows combining Traditional Chinese medicines in treatment of hypertension is cost-effective.

Analysis of clinical treatment of 233 obstructive sleep apnea hypopnea syndrome patients complicated with hypertension

Objective To analyze the anti hypertensive drugs use of clinical characteristics of obstructive sleep apnea hypopnea syndrome(OSAHS) patients complicated with hypertension. Methods 233 obstructive sleep apnea hypopnea syndrome patients complicated with hypertension were enrolled, and they were theated with three different therapy methods.After the treatment, the situations of kind, effect and combined use of oral antihypertensive drugs were statistically analyzed. Results The most frequently used drugs were calcium channel blocker(CCB), especially nifedipine sustained-release tablets[75.5%(176/233)]; the combined prescription was 63.9%(149/233) of all prescriptions, but the data reduced to 57.1%(133/233) after OSAHS therapy. Conclusion There is a good condition regarding using oral antihypertensive drugs in Weihai.However, some antihypertensive drugs are used irrationally. Key words: Antihypertensive agents; Sleep apnea, obstructive

Effect of Jingui Shenqi pill combined with nifedipine for the treatment of elderly hypertensive patients with spleen-kidney Yang deficiency syndrome

Totally 96 elderly patients with spleen-kidney Yang deficiency type hypertension were selected in this study. Patients were randomly divided into study and control group. It was treated with the Jingui Shenqi pill combined nifedipine sustained-release tablets in the study group and only nifedipine sustained-release tablets for the control group. Meanwhile, the clinical features including reducing blood pressure, blood lipid and traditional Chinese medicine (TCM) syndromes of the two groups were observed pre and post treatment. Finally, the results showed that it could significantly reduce the hypertensive, hyperlipidemia and TCM syndromes in the study group compared with the control group (P < 0.05), which indicated that the combination of the Jingui Shenqi pill with nifedipine sustained-release tablets was effective for the patients with hypertension with spleen-kidney Yang deficiency type, especially for decreasing TCM syndromes and the blood lipid.

The curative effect of comprehensive treatments for senile hypertension

Objective To study comprehensive methods for senile hypertension and compared with conven-tional western medicine treatment, and provide reference to guide clinical hypertension treatment for the future. Methods 162 cases with senile hypertension were selected in our hospital, according to the order of treatment and the principle of informed consent, they were randomly divided into observation group and control group. The control group was given conventional western medicine treatment, the Nifedipine sustained release tablets joint irbesartan tab-lets. Based on the thinkings of health management, we established health records for observation group firstly, then as-sessed cardiovascular risk among patients. The patients with low, moderate risk were conducted the continuous monito-ring of blood pressure,health education,the key intervention in their way of life, established a good mentality.If the blood pressure was still unstable and out of control, we began to consider the use of drug. For patients with high risk or very high risk, besides the treatment considered, they needed immediate medical treatment supplemented by traditional Chinese medicine. Observation group was followed up for 1 time, and lasting for 6 months, then their blood pressure was measured again, the treatment effect and adverse reactions were evaluated. Results The total effective rate of observation group was 96.7%(89／92), which was significantly higher than that of control group 82.8%(58／70),χ2＝9.12,P＜0.01, the difference was statistically significant. After following up for 6 months, the systolic blood pressure of observation group fell to(126.1±21.5)mmHg,t＝7.548,P＜0.01;diastolic blood pressure fell to (79.5±9.5)mmHg,t＝10.703,P＜0.01, the change was significantly different than before. The systolic blood pres-sure of control group fell to(145.3±26.7)mmHg,t＝1.979,P＜0.05, there was markedly reduced, diastolic blood pressure decreased too, but there was no statistical difference(P＞0.05). So the effect of observation group was better than control group. Meanwhile, some adverse reaction occurred in both groups, but there was no significant difference. Conclusion With the thinking of health management for aged patients with hypertension, offer full-course treatment for them in order to increase the awareness of hypertension and establish healthy lifestyle, guide scientific and rational drug use. The integrated use of these methods can effectively improve the effect of the treatment of senile hyperten-sion, which is worthy of popularization and application. Key words: Comprehensive method; Aged people; Hypertension

A More Rapid, Sensitive, and Specific HPLC-MS/MS Method for Nifedipine Analysis in Human Plasma and Application to a Pharmacokinetic Study

A more rapid, sensitive and specific high-performance liquid chromatography coupled to -tandem mass spectrometry (HPLC-MS/MS) was developed and validated for the quantification of nifedipine in human plasma, and applied to the pharmacokinetic study of nifedipine in Chinese healthy volunteers. Nifedipine and internal standard (IS) acetaminophen in plasma were extracted with ethyl acetate, separated on a C18 (150 mm×4.6 mm, 5 µm) reversed-phase column, eluted with acetonitrile mixed with 5 mM ammonium acetate solution (pH=6.62) (60:40, v/v), ionized by negative ion pneumatically assisted electrospray and detected in the multi-reaction monitoring mode using precursor→product ions of m/z 354.1→222.2 for nifedipine and 150.1→107.1 for the IS. A single oral dose of 20 mg nifedipine sustained release tablets and blood samples (4 mL) was collected before and 1, 2, 2.5, 3, 3.5, 4, 4.5, 5, 6, 8, 12, 24, and 36 h after administration. The main pharmacokinetic parameters of nifedipine, as Tmax, t1/2α, t1/2β, t1/2z, Cmax, AUC0~36, AUC0~∞ were 2.80±0.50 h, 6.78±2.52 h, 6.82±2.53 h, 6.69±2.22 h, 76.69±19.51 (ng/mL), 546.49±162.28 (ng · h/mL) and 564.05±176.74 (ng · h/mL), respectively. The calibration curve was linear over the concentration range of 0.17-102 ng/mL (r2>0.99, n=5) with a lower limit of quantification (LLOQ) of 0.17 ng/mL. The intra- and inter-day precision was less than 15% for all quality control samples at concentrations of 0.42, 6.53 and 81.60 ng/mL and the accuracy (relative error, RE) was - 3.92% to 7.31% at 3 quality control levels. The specificity, matrix effect, recovery, sensitivity, linearity, accuracy, precision and stabilities were validated, and can fulfill the requirement of pharmacokinetic study of nifedipine sustained release tablets in Chinese volunteers.

Clinical observation of effect of acupuncture combined with Chinese medicine footbath on hypertension treatment

Objective To observe the effect of acupuncture combined with Chinese medicine footbath on treatment of hypertension.Methods 80 cases of essential hypertension patients were randomly divided into observation group and control group. Both groups took oral Nifedipine sustained release tablets while the observation group received acupuncture combined with Chinese medicine footbath additionally. Effect of blood pressure control, symptom control and recurrence were compared.Results Total rate of blood pressure control of the observation group and the control group were 97.5% and 90%, respectively. There was no significant difference between the groups (χ2=1.81,P>0.05). The observation group showed significantly better symptom control than the control group (χ2=2.904,P<0.05). The control group showed significantly higher recurrence than the observation group (χ2=10.78,P<0.05).Conclusions Acupuncture combined with Chinese medicine footbath could effectively reduce blood pressure, improve symptoms and stabilize blood pressure. Key words: Hypertension; Acupuncture therapy; Chinese medicine footbath

E0580 Combined Nifedipine sustainedrelease tablet with betaloc to treat essential hypertension

ObjectiveTo investigate the clinical efficacy of the treatment of essential hypertension combined nifedipine sustained-release tablets with betaloc.Methods60 cases of essential hypertension discovered recently were divided into two groups in random,...