The need for new sources of renewable energy is something that is widely studied today. In several countries, the search for new sources of raw materials for biodiesel production is being evaluated and used. Among these sources is the use of animal fat waste. In this context, the use of fish waste is being evaluated and applied as an intensive source in the production of biodiesel. However, the development of technologies that can make the extraction of these fats viable is still a determining factor in the full use of these wastes. This study presents a review of the production of Nile Tilapia, farmed in captivity, as well as its use in the production of and application in the biodiesel production chain. This work, because it is a review of the potential for the use of waste, used a systematic assessment of the collection of studies, market assessments, and government agencies, which made it possible to obtain data on production and waste generation. For this purpose, searches were carried out on journal platforms and websites that involve the fish production chain. Thus, the verification of this new source of biomass in energy generation becomes viable for the development of new technologies that can add value to waste and reduce the environmental impacts caused by fish farming. The study indicates that there is a significant opportunity in the use of fish waste for the production of renewable fuels, specifically those that have a high lipid content, and their use for the production of biodiesel is possible.