New Paradigm Of Cooperation Research Articles

Development Dynamics in South-Eastern Europe: The Challenge of the New Paradigm of Cooperation

At the core of the process of revisiting the contemporary viewpoints regarding the issue of Development and International Relations, lies the Dynamic of Globalization. This does not cease to transform the evolutionary nature of global capitalism in all its dimensions, in all business, spatial and sectoral contexts. The Dynamic of Globalization which effectively makes a dent in the logic of the hedged about National Socioeconomic Space challenges our conventional wisdom. It also does not cease to build an unbreakable evolutionary unity of the different socioeconomic agents, gradually becoming more and more dense and strong in interactions and co-determinations, in uniform spatial terms. The issue of Competitiveness in the context of globalization is gradually emerging as the new epicenter of the Development and International Relations debate. Specifically, in globalizing process, Competitiveness is simultaneously produced by A) the accommodating Socioeconomic Space B) the incumbent Businesses and C) by materialization within the specific historical context of productive and Industrial Structures and dynamics articulated on a global scale. Searching Competitiveness the different socio-economic spaces, agents and industries are structurally unified in progressive manner. This approach of Competitiveness and Development in Global scale can help towards the progressive formation of a new Paradigm of Cooperation, which requires the upending of several conceptual fixations of the past.

Cross-border Downstream Benefit Sharing in Reservoir Type Hydropower Projects: Case of Budhi Gandaki Storage Project in Nepal

This paper analyses the role of the principle of downstream benefit sharing under international water law regime in the management of cross-border water courses. This paper argues that the principle of downstream benefit sharing may play a key role in wiping away the long-existing distrust between countries as well as hold the potential to usher in a new phase of cooperation between riparian neighboring countries, such as Nepal and India. If pursued in good faith the downstream benefit principle would enjoin erstwhile losers of the vast potential to a cooperative mechanism where they could find themselves in a win-win situation. The Budhi Gandaki Storage Project presents a unique opportunity for employing this new paradigm of cooperation between two countries: Nepal and India. In this paper, we present the example of India that is facing a water and energy crisis for which it may ease to a considerable extent its problem by depending on Nepal for these resources. Downstream benefit sharing may provide India an opportunity to gain the confidence of the Nepalese people for developing many hydro projects with or without water augmentation resulting into multiple benefits downstream in India. Employing the downstream benefit sharing principle might requirere visiting treaties like Gandak Project Agreement.DOI: http://dx.doi.org/10.3126/hn.v14i0.11267HYDRO Nepal JournalJournal of Water, Energy and EnvironmentVolume: 14, 2014, JanuaryPage: 59-64

Unexpected paracrine action of prostate cancer cells harboring a new class of androgen receptor mutation—A new paradigm for cooperation among prostate tumor cells

The emergence of mutations in the androgen receptor (AR) gene is a recurrent event during progression of prostate cancer (PCa) on androgen ablation therapy. In this study, we show that nonsense mutations that lead to carboxyl-terminal end truncated ARs are found at high frequency in metastatic PCas. Transcriptional activities of the Q640X mutant AR in the androgen-sensitive LNCaP cell line differ to those of the wild-type AR. Indeed, this mutant AR exhibits strong and ligand-independent transcriptional activities from an artificial promoter construct containing two repeats of androgen-responsive elements, but is inactive on the human PSA gene promoter. Nevertheless, the expression of the Q640X mutant AR in LNCaP cells is accompanied by an increase in the level of PSA protein, and by an increase in the expression of the endogenous AR gene. This enhanced expression of the endogenous AR gene is not limited to the sole transfected cells, but is observed in non-transfected neighboring cells. Additionally, in co-cultures of transfected and non-transfected LNCaP cells, the Q640X mutant AR leads to an unpredicted nuclear localization of the endogenous AR protein in the two cellular populations and this, in the absence of androgen. These data indicate that cells expressing the Q640X mutant AR acquire the property to emit a signal that activates the AR in neighboring cells by a paracrine mechanism and in a ligand-independent manner. Our data strongly support the notion of cooperation among tumor cells in PCa and could be of relevance for the understanding of progression on androgen ablation therapy.

Regulation of RUNX1 Transcriptional Function by GATA-1 Kinase Recruitment: A Novel Pathway for Megakaryocytic Gene Regulation.

RUNX1 and GATA-1 both play essential roles in the transcriptional programming of normal mammalian megakaryocytic development, deficiencies of either factor having similar phenotypic consequences. We have previously characterized physical and functional interactions between these two factors, and others have confirmed analogous cooperations in Drosophila and Danio homologs. We now present data on molecular mechanisms for the cooperation of these two factors in the transcriptional activation of the megakaryocytic aIIb integrin promoter. In these studies, GATA-2 also physically interacted with RUNX1 but failed to cooperate in transcriptional activation. In fact, increasing amounts of GATA-2 repressed the functional interplay between GATA-1 and RUNX1. Through generation of GATA-2/GATA-1 chimeras, we identified a conserved subdomain within the GATA-1 amino terminus that was both necessary and sufficient for transcriptional cooperation with RUNX1. Coexpression of wild type GATA-1 or of cooperating GATA-2/GATA-1 chimeras, but not of GATA-2 or of non-cooperating chimeras, induced a mobility shift in wild type RUNX1. Using immunoprecipitation followed by immunoblot with a panel of phosphospecific antibodies, we found GATA-1 to induce RUNX1 phosphorylation at recognition sites for cyclin-dependent kinases (cdks). Treatment of cells with roscovitine, a specific cdk inhibitor, blocked the transcriptional cooperation of GATA-1 with RUNX1 and eliminated the RUNX1 mobility shift caused by GATA-1 coexpression. Mutagenesis of RUNX1 identified a cluster of serine/threonine-proline (S/TP) sites collectively required for the transcriptional augmentation and mobility shift induced by GATA-1. In addition, intact DNA binding by RUNX1 was required for cooperation with GATA-1. These results provide a new paradigm for cooperation of interacting transcription factors, in which one partner recruits a kinase leading to phosphorylation and activation of the other partner. Furthermore, these results provide a biochemical basis for the previously inexplicable functional differences between GATA-1, which promotes megakaryocytic maturation, and GATA-2 which promotes proliferation without maturation.

The impact of ISO 14000 on developing world businesses

ISO 14000 has attracted interest from industry, international organizations and governments around the globe. Policy-makers and industry both appear to be looking to the standards as a key component of a new paradigm for cooperation between regulators and industry. This realization seems to have resulted from a growing awareness that the fragmented, reactive approach to environmental management in the past has not produced optimal results. Businesses are realizing the value of integrating their compliance procedures for each regulation into a broader system. Compliance problems can often be linked to system problems such as inadequate training, lack of responsibility at the right level, inadequate data, and other related causes. An effective Environmental Management System (EMS) eliminates these pitfalls. The evolution of the EMS is being shaped by market forces, ISO 9000, regulatory shifts, public awareness, and cost implications for ISO certifications. The transformation of these management practices is not limited to industrialized countries. In anticipation of the non-tariff trade barriers that could be erected as a result of these standards, many developing countries are seeking avenues of compliance with ISO 14000's requirements. Egypt should be concerned with the implementation of this system, for firms in countries of the European Community (EC) have been given explicit instructions by the three prevalent European standard-setting organizations to “familiarize” themselves with the requirements of ISO 14000. This paper will focus primarily on the expected effects of ISO 14001

Perspectives on a New Paradigm for Cooperative Research

New partnership paradigms are appearing today as American industry seeks new ways to meet international competition. This challenge is a primary national need. Industrial cooperation with universities, government, and companies is being promoted to identify, develop, and apply technologies to new products in a more timely and effective manner. This paper gives one company's perspectives on improving cooperation to leverage resources and improve our national position in the global technology competition. To provide a perspective, the history of support of engineering and science research by the Federal government and by industry is reviewed. Several models of cooperation between universities, industry, and government are cited, noting trends and areas open for innovation. A suggested new paradigm for cooperation is described. Example cooperative projects of Control Data are identified. An implementation by Control Data of the new paradigm, the Engineering Center Network, is described in some detail.