New Lease Of Life Research Articles

A radio telescope in the Arctic region

A former ALMA prototype antenna has a new lease of life in the harsh conditions of Greenland, where it will play a key role in very-long-baseline interferometry observations of supermassive black holes, explain Nimesh Patel and Paul Ho.

PHOTOESSAY: Buried in debt only to have their loved ones get a burial

The photoessay Healing The Wounds From the Drug War was the trail of people’s lives that have been disrupted by this brutal campaign in the Philippines. It was about what happens to those people left behind after the killings. Some who survive end up in decrepit jails. The families of the dead, mostly from the poor who get by in hand-to-mouth existence, end up buried in debt only to have their loved ones get a burial. But it also a story of hope for those given a new lease of life by organisations willing to assist in the rehabilitation of drug addicts.

Shame in early modern thought: from sin to sociability

ABSTRACTThis article challenges the historiographical narrative that modernity saw a transition from shame to guilt. I argue not only that these two concepts overlapped, but that, if anything, a shift occurred in the opposite direction: from guilt to shame. I identify two concepts of shame: guilt-shame, focused on sinfulness and caused by mere introspection, and reputation-shame, focused on social norms and caused by the (albeit imagined) gaze of others. Looking primarily at English texts, straying often into the European republic of letters, I argue that in the seventeenth century, as Biblicist fervour gave way to natural religion and a naturalistic turn in moral philosophy, and as burgeoning public spheres needed governing, reputation-shame experienced a new lease of life. This argument, in turn, questions the characterisation of the modern self as private, insulated and autonomous, gesturing instead at open, social minds that were nonetheless deeply, passionately, interiorised. In picking apart these interwoven strands in the history of the concept of shame, I hope to make the methodological point that one cannot be essentialist about concepts. There is no concept of shame that can be analysed abstracted from time and space, only particular uses of the concept in particular utterances.

The Entanglements of Europe: History, Geography, Identity

Europe is a continent of extraordinary variety and diversity geographically, ethnically, nationally, culturally, economically and politically. Yet at the same time all its parts are and always have been so deeply linked by their destiny that this continent can accurately be described as a single albeit complex political entity. Anything crucial in any area of human endeavour occurring anywhere in Europe always has had both direct and indirect consequences for our continent as a whole. The history of Europe is, in fact, the history of a constant searching and reshaping of its internal structures and the relationship of its parts. Today, if we talk about a single European civilization or about common European values, history, traditions, and destiny, what we are referring to is more the fruit of this tendency toward integration than its cause.

Evaluation of classification performance of functional near infrared spectroscopy signals during movement execution for developing a brain–computer interface application using optimal channels

The objective of brain–computer interface application is to give a new lease of life to motor-impaired people by enabling them to communicate with the external world purely based on thoughts. Functional near infrared spectroscopy technology uses light to detect brain activations related to the motor activity performed by the subjects and an emerging modality in the brain–computer interface field. The study aims at comparing haemodynamic responses during upper limb movement tasks and resting condition over 14 channels placed equally on right and left hemispheres. Channel selection based on statistical methodology has been introduced to optimally select those channels that give statistical differences between the motor tasks. Besides using commonly used features such as mean, variance and peak of oxygenated haemoglobin signal, two other features, namely difference between mean concentration changes of oxygenated haemoglobin and deoxygenated haemoglobin and difference between mean activation level of oxygenated haemoglobin during the task condition and mean activation level of oxygenated haemoglobin during the resting state, are investigated. Their effect on the artificial neural network classifier accuracy over the selected channels is analysed. The proposed channel selection strategy is compared with the channel-averaging approach, which is one of the conventional channel selection methods. Also, performance of these methods is compared when all 14 channels are considered for classification. Classification of functional near infrared spectroscopy signals corresponding to motor tasks and rest condition gave accuracy values of (87.25 ± 8.66)% over 14 channels, (83.81 ± 5.97)% over channels selected using channel-averaging method and (84.71 ± 4.97)% over the selected subset of four channels. Hence, the results in terms of classification accuracies are promising and demonstrate the prospect of developing functional near infrared spectroscopy-based brain–computer interface application. Also, the analysis carried out in the study showed that the upper limb motor tasks evoked different haemodynamic responses in the reduced set of channels located over centro-parietal regions of the brain.

Consultant engineers give endoscopy facilities a new lease of life

Consultant engineers give endoscopy facilities a new lease of life

Digital trade coin: towards a more stable digital currency.

We study the evolution of ideas related to creation of asset-backed currencies over the last 200 years and argue that recent developments related to distributed ledger technologies and blockchains give asset-backed currencies a new lease of life. We propose a practical mechanism combining novel technological breakthroughs with well-established hedging techniques for building an asset-backed transactional oriented cryptocurrency, which we call the digital trade coin (DTC). We show that in its mature state, the DTC can serve as a much-needed counterpoint to fiat reserve currencies of today.

How retirement can give your career a new lease of life.

Scientists who step back from full-time work can find plenty of ways to remain active in their research field. Scientists who step back from full-time work can find plenty of ways to remain active in their research field.

Staurosporine: new lease of life for parent compound of today's novel and highly successful anti-cancer drugs.

Staurosporine, together with such examples as penicillin, aspirin, ivermectin and sildenafil, exemplifies the role that serendipity has in drug discovery and why 'finding things without actually searching for them' retains a prominent role in drug discovery. Hitherto not clinically useful, due to its potency and promiscuity, new delivery technology is opening up new horizons for what was previously just the parent compound of innovative, highly-successful anti-cancer agents.

Structure of 4-(Dimethylamino)benzonitrile Using Gas Electron Diffraction: A New Lease of Life for the Only Gas Electron Diffractometer in the U.K. .

The continued demand for gas-phase molecular structures has led to the recommissioning of a gas electron diffractometer, formerly housed at the University of Reading. The gas electron diffractometer, now the only one of its kind in the U.K., is currently housed at the University of York, where it is now used routinely to determine directly structures of isolated molecules in the gas phase. The instrument has been fitted with an air-heated nozzle assembly to increase the range of molecules accessible to study in the gas phase; the efficacy of this assembly is demonstrated in this article via the determination of the gas-phase structure of 4-(dimethylamino)benzonitrile (DMABN) at high temperature. A series of complementary theoretical calculations using the B2PLYP DFT functional of Grimme et al. with correlation-consistent basis sets of double, triple, and quadruple-ζ quality are also presented. The agreement between the experimental and theoretical structural parameters attests to the accuracy of the applied theoretical calculations and of our gas-phase structural solution.

Full Circle

The Boeing 787's troubled service entry and new engine technology have given the Airbus A330 a new lease of life

EDITORIAL

Both Antiquity and archaeology have changed immeasurably since O.G.S. Crawford penned this journal's first editorial in 1927. The discipline has grown in size and sophistication, and has achieved professional status and public recognition. What was novel at that time, such as aerial photography and the use of ethnographic parallels, both flagged in that first editorial, have now long been integral to archaeological theory and practice. Antiquity has documented—and often driven—these developments, itself evolving along the way. Nine decades after its foundation, Antiquity publishes more content, on more varied periods and places, and authored by an ever-more international cast of contributors. It has also changed in terms of its audience. Part of Crawford's original vision was to communicate archaeology more effectively to the general public, not least with the intention of debunking the misleading, sensationalist and downright incorrect fare peddled in the bestsellers and newspapers of the day. The content of Antiquity today is aimed at a more professional readership, what one previous editor, Martin Carver, called “the extended archaeological family” of academics and field archaeologists, and the many associated specialists in cognate disciplines with whom we work. All these developments notwithstanding, it is striking that many of Crawford's concerns and interests still continue to resonate. The disciplinary imperative to communicate with the public is stronger than ever, finding new opportunities in social media, blogs and TV programmes, and under pressure from funding bodies to demonstrate public benefit or ‘impact’. The analytical, and aesthetic, importance of aerial photography that Crawford worked hard to promote has too taken on a new lease of life through satellite imagery, LiDAR and, most recently, photography using drones or unmanned aerial vehicles (see Frontispiece 1).

The rebelling orphan: adopting the found photograph

Every day thousands of family photographs get abandoned in second hand bookshops, at flea markets, and internet auctions, losing their past and having their stories erased. Conversely, the same images get found, reappropriated, and assigned with new meanings. It is this process of giving the found photograph a new lease of life that I explore in this article. As I argue here, photographs continue to act as potent narrative tools even if we no longer have access to their subjects or producers. Not only do I show how anonymous photographs can be read and interpreted but also how they function as material objects that are collected, loved, treasured, and inevitably integrated into the lives of their new adopted families. I show, in particular, how both the content and the materiality of photographs makes them carriers of family history and private memory, as well as intersecting with other categories such as class and identity.

Recyclable Materials (Waste) Management in Enterprise’s Production Process

Currently, in view of the increasing garbage crisis, the notion of a “new lease of life” for waste becomes even more relevant. Waste recycling makes it possible not only to solve obvious environmental problems, but also to offer new resource opportunities for industries. Among the obvious economic, social and environmental advantages, however, waste recycling meets various problems. These problems and solutions for them, as well as the problems of economic efficiency improvement and recycling activities’ appeal for industrial companies in Leningrad region, are discussed in the present study.

A 'new lease of life': FnCpf1 possesses DNA cleavage activity for genome editing in human cells.

Cpf1 nucleases were recently reported to be highly specific and programmable nucleases with efficiencies comparable to those of SpCas9. AsCpf1 and LbCpf1 require a single crRNA and recognize a 5′-TTTN-3′ protospacer adjacent motif (PAM) at the 5′ end of the protospacer for genome editing. For widespread application in precision site-specific human genome editing, the range of sequences that AsCpf1 and LbCpf1 can recognize is limited due to the size of this PAM. To address this limitation, we sought to identify a novel Cpf1 nuclease with simpler PAM requirements. Specifically, here we sought to test and engineer FnCpf1, one reported Cpf1 nuclease (FnCpf1) only requires 5′-TTN-3′ as a PAM but does not exhibit detectable levels of nuclease-induced indels at certain locus in human cells. Surprisingly, we found that FnCpf1 possesses DNA cleavage activity in human cells at multiple loci. We also comprehensively and quantitatively examined various FnCpf1 parameters in human cells, including spacer sequence, direct repeat sequence and the PAM sequence. Our study identifies FnCpf1 as a new member of the Cpf1 family for human genome editing with distinctive characteristics, which shows promise as a genome editing tool with the potential for both research and therapeutic applications.

Why Money Cannot Buy Happiness. The Painful Truth about Traditional Proverbs and Their Modifications

Can one imagine language without proverbs? Do we really need these somewhat cliched adages like An apple a day keeps a doctor away, Once bitten, twice shy, or Crime doesn’t pay? Are they still influential, or perhaps modern society should give them a new lease of life? This paper aims to reveal the “painful truth” behind traditional proverbs and especially their modified versions. Leading paremiologists (Wolfgang Mieder, Nihada Delibegovic Džanic, Anna Litovkina) introduce a number of terms in reference to the latter, and so this study discusses the etymology and the semantic import of such labels as anti-proverbs, twisted proverbs, quasi-proverbs, and pseudo-proverbs. However, its basic aim is to propose a classification of modified proverbs based on a number of examples, such as Man proposes, mother-in-law opposes; A good beginning is half the bottle; Crime pays – be a lawyer; A new broom sweeps clean, but the old one knows the corners, and many others. Finally, based on Ronald Langacker’s conception of the profile-base distinction, deriving from the figure-ground alignment, this paper makes an attempt to prove the necessary link between traditional proverbs and their innovative modifications.

Reforestation in Algeria: History, current practice and future perspectives

Reforestation in Algeria has been recognized as a priority in different programs for the development and enhancement of forest heritage. Degradation factors of forest and soil contribute significantly to the decline in land values. The Algerian forests in the past, during the colonial period suffered considerable degradation. The degraded forest heritage has been undertaken with serious programs since independence. Several programs for the development of the forest sector through reforestation have been carried out. Unfortunately, the achievements were still below expectations. The launch of the National Reforestation Plan in 2000 has given the forestry sector a new lease of life with a vision that incorporates the productive aspect of reforestation, the industrial aspect, and the recreational aspect. Before the end of the NRP timeline, significant reforestation projects are completed. In a future projection, reforestation is integrated into the land use planning within the framework of the National Plan of Land Use Planning.

Students’ Perception Towards National Examination 2017: Computer-Based Test or Paper-Based Test

Abstract Today, technological development has given a new lease of life in language learning and teaching field. Particularly in terms of evaluation, some schools in Indonesia conduct national examination using computer-based test. Traditionally, testing in a class involves paper-based test which is familiar to students. A substantial number of studies have been conducted to compare both of the tests. The researcher investigated what activities were performed by the students throughout the tests, what kind of multiple choice tests the students prefer to do, and what the positive and negative side of those tests. This study presents a wonder share quiz creator (WSQC) program to facilitate the teachers to design a test. The data was collected by questionnaire, interview, observation, and quiz. In this study, the authors concluded that students in senior high school of Kendari prefer paper-based test for national examination.

A new lease of life for a controversial wonder-drug? The latest on statins

A new lease of life for a controversial wonder-drug? The latest on statins

MOTOR IMAGERY – A CONCISE REVIEW ON ITS HISTORICAL DEVELOPMENT, ITS PRESENT USE AND FUTURE APPLICATION

Not long after Motor Imagery established itself as an effective training tool in professional sports, it found its way into therapy. Mental execution of single-movements and movement sequences has henceforth been compared to actual movements and revealed surprising similarities. Different forms have been created and assessments for testing individual abilities have been developed and refined. Until now, Motor Imagery has been successfully integrated into the treatment of several patient categories. Present-day imaging modalities allow for in-depth understanding of underlying mechanisms. Several neuroplastic alterations and mechanisms of adjusted cortical excitability are explainable, by now. Motor imagery can nowadays be implemented or supported by technologies and therefore is finding a new lease of life by reinventing itself. However, Motor Imagery has repeatedly been a subject of debate. Therefore, a concise review is given, retrospecting the historical background, naming similarities and differences of actual and imagined movement, shedding light on underlying neuronal mechanisms and critically discussing the implementation of Motor Imagery in various fields of therapy. Lastly, future development of Motor Imagery is discussed.