New Approach For Assessment Research Articles

Evolution of Maintenance Systems of Passenger and Freight Wagons from the ECM Certification Point of View

RCM and ECM are abbreviations seemingly the same though the meaning is different. However, they have lot of common as the both are aimed at increased reliability of operation and minimising risk. RCM stands for Reliability Centred Maintenance and ECM stands for Entity in Charge of Maintenance, thus maintenance is the common term for both. Indeed, maintenance is a key for increased safety and reduced risk. The paper presents basic principles and theory behind the RCM - an advanced maintenance concept with its origin in aviation and consequently applied in industries connected with high level of risk, such power generation, etc. The ECM certification is a new approach for assessment of how railway vehicles operators are managing the risks connected with operation of the rolling stock. Entities, either owners or keepers of the rolling stock, are those who are responsible for the technical condition guaranteeing safety of railway traffic. There is common European methodology (requirements) for assessing the competence of ECMs based on EC Regulation No. 445/2011. Behind this methodology are efforts to minimise risks of freight trains operation and prevent serious accidents resulting from improper maintenance and insufficient technical state. In line with these efforts is our proposal for implementation of RCM in railway vehicles maintenance.

Humans and Ecosystems Over the Coming Millennia: Overview of a Biosphere Assessment of Radioactive Waste Disposal in Sweden

This is an overview of the strategy used to describe the effects of a potential release from a radioactive waste repository on human exposure and future environments. It introduces a special issue of AMBIO, in which 13 articles show ways of understanding and characterizing the future. The study relies mainly on research performed in the context of a recent safety report concerning a repository for spent nuclear fuel in Sweden (the so-called SR-Site project). The development of a good understanding of on-site processes and acquisition of site-specific data facilitated the development of new approaches for assessment of surface ecosystems. A systematic and scientifically coherent methodology utilizes the understanding of the current spatial and temporal dynamics as an analog for future conditions. We conclude that future ecosystem can be inferred from a few variables and that this multidisciplinary approach is relevant in a much wider context than radioactive waste.

Assessment of CanMEDS roles in postgraduate training: The validation of the Compass

ObjectiveIn medical education the focus has shifted from gaining knowledge to developing competencies. To effectively monitor performance in practice throughout the entire training, a new approach of assessment is needed. This study aimed to evaluate an instrument that monitors the development of competencies during postgraduate training in the setting of training of general practice: the Competency Assessment List (Compass). MethodsThe distribution of scores, reliability, validity, responsiveness and feasibility of the Compass were evaluated. ResultsScores of the Compass ranged from 1 to 9 on a 10-point scale, showing excellent internal consistency ranging from .89 to .94. Most trainees showed improving ratings during training. Medium to large effect sizes (.31–1.41) were demonstrated when we compared mean scores of three consecutive periods. Content validity of the Compass was supported by the results of a qualitative study using the RAND modified Delphi Method. The feasibility of the Compass was demonstrated. ConclusionThe Compass is a competency based instrument that shows in a reliable and valid way trainees’ progress towards the standard of performance. Practice implicationsThe programmatic approach of the Compass could be applied in other specialties provided that the instrument is tailored to specific needs of that specialism.

Bivalent response to long‐term storage in liquid‐preserved boar semen: A flow cytometric analysis

The fertility of liquid-preserved boar semen declines during storage at 17°C, insemination trials even indicating early losses in fertilizing ability within the first 24-48 h of storage. Standard semen parameters barely reflect these changes in semen quality, and new approaches for assessment of functional changes in stored spermatozoa are needed. Capacitation, the essential prefertilization step for spermatozoa in the female genital tract, is specifically induced in vitro by bicarbonate. Therefore, we have investigated changes in responsiveness of boar spermatozoa to bicarbonate during storage. Ejaculates of 14 boars were diluted in Beltsville thawing solution, cooled to 17°C and stored for 12, 24, 72, 120, and 168 h before investigation. At each time, basic semen quality was characterized by sperm motility and viability. Subsequently, washed subsamples were incubated in variants of an in vitro fertilization (IVF) medium and assessed for kinetic changes of viability (plasma membrane integrity) and intracellular calcium concentration using flow cytometry in combination with propidium iodide and Fluo-3. By this means, it was possible to determine specific effects of bicarbonate and calcium on sperm subpopulations over incubation time. During storage, standard semen parameters remained on a high level. However, flow cytometric analysis of sperm responses to capacitating and control media revealed two opposing effects of storage. There was a loss of response to bicarbonate in part of the live sperm population but an increasing degree of instability in the rest. Assessment of response to capacitating media by flow cytometry appears a markedly more sensitive way of monitoring sperm functionality during storage than the standard semen parameters of motility and viability.

A New Approach for Assessment of Mental Architecture: Repeated Tagging

A new approach to the study of a relatively neglected property of mental architecture—whether and when the already-processed elements are separated from the to-be-processed elements—is proposed. The process of numerical proportion discrimination between two sets of elements defined either by color or by orientation can be described as sampling with or without replacement (characterized by binomial or hypergeometric probability distributions respectively) depending on the possibility to tag an element once or repeatedly. All empirical psychometric functions were approximated by a theoretical model showing that the ability to keep track of the already tagged elements is not an inflexible part of the mental architecture but rather an individually variable strategy which also depends on conspicuity of perceptual attributes. Strong evidence is provided that in a considerable number of trials, observers tagged the same element repeatedly which can only be done serially at two separate time moments.

New approaches in assessment of tsunami deposits in Dalaman (SW Turkey)

New approaches in assessment of tsunami deposits in Dalaman (SW Turkey)

New approaches in assessment of tsunami deposits in Dalaman (SW Turkey)

Some earthquakes in the Eastern Mediterranean are tsunamigenic and some of their tsunamis affected the coastal area of the Gulf of Fethiye, SW Turkey. Recent trenching surveys on the low-lying coastal areas of Dalaman delta beach across the Rhodes Pass revealed three probable tsunami impacts as a result of the historical earthquakes of 1303, 1481 and 1741. Yet, there have been relatively few studies of the processes associated with tsunami sediment transport, their deposition and nature in geological record. In addition to the interpretation of sedimentary features, accurate paleoenvironmental assessments might be possible by distinctive biogeochemical researches on marine-sourced organic matters, geochemical properties, quantitative amounts of marine-sourced biomarkers and deterministic ratios. The identification of major lipid biomarkers (fatty acids and sterols) in the samples recovered from the sidewalls of the studied trench, for example, indicated biogenic contributions due to the presence of phytoplankton, zooplankton, dinoflagellates and bacteria. Quantitative estimation of biomarkers and deterministic ratios also indicated some evidences for marine-sourced organic matters, implying that biomarkers can be used to answer the open questions in tsunami and paleotsunami researches.

A New Approach for Assessment and Comparison of Websites: Using the Modified Balanced Scorecard and Analytical Hierarchy Process

This exploratory study was designed to develop an instrument for evaluation of websites using the modified balanced scorecard (BSC) and analytical hierarchy process (AHP), and compare its differences between the hospitality and tourism area. For the first step, the 4 evaluation perspectives and critical success factors (CSFs) were developed based on the modified BSC and a literature review. For the second step, a final website evaluation instrument was constructed through AHP. Through these processes, the final instrument was developed. The results indicated that the two CSFs—user-friendliness and user security—appeared to be the most important factors for hospitality and tourism website among CSFs. Also, customer perspective was the most important of the 4 perspectives. The present study will help broaden knowledge about website evaluation.

Left atrial flow propagation velocity: a new approach for assessment of left atrial reservoir function

To assess the feasibility of left atrial flow propagation velocity (LAFPV) measurement and to evaluate the influence of preload alterations on this new parameter of left atrial (LA) reservoir function as compared to conventional echocardiographic indices. 30 healthy volunteers (26 ± 5 years, 20 males) underwent echocardiographic examination at rest, during passive leg lifting and after sublingual administration of nitroglycerine with subsequent Valsalva maneuver. LA reservoir function was assessed by conventional indices including LA expansion index, peak velocity and velocity-time integral of pulmonary venous systolic flow. As well, LAFPV was measured by color M-mode in an apical 4-chamber view as the slope of the transatrial flow wave during LA reservoir phase. LAFPV measurement was feasible in 25 subjects (83%). All conventional parameters of LA reservoir function were significantly altered from resting values by both load-modifying conditions. However, LAPFV was not significantly altered by such maneuvers (228 ± 28 cm s⁻¹ at rest vs. 238 ± 3 cm s⁻¹ during leg lifting, P = NS, vs. 218 ± 38 cm s(-1) after nitroglycerin with Valsalva maneuver, P = NS vs. rest, P < 0.01 vs. leg lifting). LAFPV can be measured in a majority of subjects and represents a new, less load-dependent index of LA reservoir function that may more appropriately reflect LA compliance.

New approach for assessment of potential ethnic differences in parallel phase l/ll studies in the United States and Asia.

2549 Background: Potential ethnic differences such as drug metabolism between Asian and U.S. patients has been considered one of the major obstacles for simultaneous drug development. To evaluate t...

Application of Objective Structured Clinical Examination in Community Health Nursing Course: Experience of Staff Members and Students

Objective Structured Clinical Examination (OSCE) is the most valid and reliable tool for evaluation of performance competency. There are different formats of OSCE to assess the cognitive and psychomotor skills as well as the knowledge recall and communication skills in an objective and consistent manner. It is important to involve students and examiners in changing or innovating of evaluation pattern. The present study aimed to investigate the perception and experience of staff members and students toward introducing OSCE as a new approach of assessment in community health nursing course. In addition to compare the applicability of using three different structured methods of simulated patient (Lay person with staff members, Staff members play double roles and two staff members), in order to find out the most appropriate simulated patient method. The study is a mix of quantitative and qualitative design. It was carried out at the fourth year community health-nursing students, totaling 160 students. All examiners (n= 16) and only 60 students participated at the focus group sessions. Results revealed that most of students and examiners were satisfied with the objectivity of OSCE and the variety of questions that increase the chance of gaining marks. The students' level of performance ranged from good to excellent in all stations for most of students. The study recommends introducing OSCE into the curriculum of community health nursing course and holding comprehensive training for staff members on being a simulated patient and examiner at the same time.

Mapping knowledge investments in the aftermath of Hurricane Katrina: a new approach for assessing regulatory agency responses to environmental disaster

Abstract In the aftermath of large-scale disasters, the public's dependency on federal and state agencies for information about public safety and environmental risk is acute. While formal rules and procedures are in place to guide policy decisions in environmental risk assessment of spatially concentrated hazards such as regulated waste sites or vacant city lots, standard procedures for risk assessment seem potentially less well-suited for urban-scale disaster zones where environmental hazards may be widely dispersed and widely varying. In this paper we offer a new approach for the social assessment of regulatory science in response to large-scale disaster, illustrating our methodology through a socio-spatial analysis of the U.S. Environmental Protection Agency's (EPA) hazard assessment in New Orleans, Louisiana, following Hurricane Katrina in 2005. We find that the agency's commitment of epistemic resources or “knowledge investments” varied considerably across the flood-impacted portion of the city, concentrating in poorer and disproportionately African American neighborhoods previously known to be heavily contaminated. We address some of the study's social and policy implications, noting the multidimensionality and interactive nature of knowledge investments and the prospects for deepening and extending this approach through comparative research.

Periodic squat‐stand: A new approach for assessment of cardiac baroreflex function in humans

A new approach for assessment of baroreflex function in humanss was developed in this study. Arterial pressure and R‐R interval were recorded in 10 healthy young (30 ± 5 yrs) and 8 elderly subjects (66 ± 6 yrs). Periodic squat‐stand maneuvers were performed at the frequencies of 0.05 and 0.1Hz respectively to produce large oscillations in arterial pressure to stimulate the baroreflex. Transfer function between changes in arterial pressure and R‐R interval was estimated to assess the cardiac baroreflex sensitivity (gain) and the temporal relations (phase) between these variables. During squat‐stand maneuvers, spectral power of oscillations in systolic blood pressure at the frequency of 0.05 Hz was 374 ± 191 mmHg2 in young and 561± 321 mmHg2 in the elderly, and at the 0.1Hz was 253 ± 119 mmHg2 in young and 203 ± 87 mmHg2 in the elderly. In response to these changes in arterial pressure, large oscillations in R‐R interval also were created at the frequencies of 0.05 and 0.1Hz respectively. When compared with the young, transfer function gain was reduced, while the phase became more negative in the elderly. In conclusion, periodic squat‐stand maneuvers produced large and coherent oscillations in arterial pressure and R‐R interval. Transfer function analysis between these variables provides a new and widely available method for assessment of dynamic baroreflex function in humans. Application of this method showed that not only was cardiac baroreflex sensitivity was reduced, but also the heart rate response to changes in arterial pressure was delayed in the elderly.

A new approach for assessment of wear in metal-backed acetabular cups using computed tomography: A phantom study with retrievals

Background and purpose Polyethylene wear is an important cause of aseptic loosening in hip arthroplasty. Detection of significant wear usually happens late on, since available diagnostic techniques are either not sensitive enough or too complicated and expensive for routine use. This study evaluates a new approach for measurement of linear wear of metal-backed acetabular cups using CT as the intended clinically feasible method.Material and methods 8 retrieved uncemented metal-backed acetabular cups were scanned twice ex vivo using CT. The linear penetration depth of the femoral head into the cup was measured in the CT volumes using dedicated software. Landmark points were placed on the CT images of cup and head, and also on a reference plane in order to calculate the wear vector magnitude and angle to one of the axes. A coordinate-measuring machine was used to test the accuracy of the proposed CT method. For this purpose, the head diameters were also measured by both methods.Results Accuracy of the CT method for linear wear measurements was 0.6 mm and wear vector angle was 27°. No systematic difference was found between CT scans.Interpretation This study on explanted acetabular cups shows that CT is capable of reliable measurement of linear wear in acetabular cups at a clinically relevant level of accuracy. It was also possible to use the method for assessment of direction of wear.

Isolation and selection of Bacillus spp. as potential biological agents for enhancement of water quality in culture of ornamental fish

To isolate, select and evaluate Bacillus spp. as potential biological agents for enhancement of water quality in culture of ornamental fish. Natural isolates obtained from mud sediment and Cyprinus carpio were purified and assessed in vitro for efficacy based on the inhibition of growth of pathogenic Aeromonas hydrophila and the decrease in concentrations of ammonium, nitrite, nitrate and phosphate ions. Based on suitability to predefined characteristics, the isolates B001, B002 and B003 were selected and evaluated in vitro in the presence of Aer. hydrophila and in a preliminary in vivo trial with C. carpio. The inhibitory effect on pathogen growth and the decrease in concentrations of waste ions was demonstrated. Based on 16S RNA sequence homology, the isolates were identified as Bacillus subtilis, Bacillus cereus and Bacillus licheniformis, respectively. Isolate B002 did not contain the anthrax virulence plasmids pOX1, pOX2 or the B. cereus enterotoxin. Selected isolates effected synergistic reduction in pathogen load and the concentrations of waste ions in vitro and in vivo and are safe for use in ornamental aquaculture. A new approach for assessment of biological agents was demonstrated and has yielded putative isolates for development into aquaculture products.

Evaluation of the damage in fish spermatozoa cryopreservation

Cryodamages occur during sperm cryopreservation. Cryopreservation of fish sperm usually results in marked decrease in sperm quality, such as swelling or disruption of the plasma membrane, mitochondrial dysfunction, diminished sperm motility, impaired velocity, shorter motility period, denaturation, and release of some enzymes from spermatozoa. In this paper, damages in morphology, physiology, biochemistry and metabolism, and genetic integrity of fish semen after cryopreservation are discussed. New approaches in assessment of fish thawed sperm quality such as computer assisted sperm analysis, flow cytometic analysis combined with fluorescent probes and single cell gel electrophoresis are also briefly reviewed.

Transbronchial Biopsy Guided by Low-Dose MDCT: A New Approach for Assessment of Solitary Pulmonary Nodules

The objective of our study was to determine whether transbronchial bronchoscopic biopsy of solitary pulmonary nodules under CT guidance using a low-dose protocol can increase diagnostic yield in patients who had undergone unsuccessful conventional bronchoscopic biopsy. We included 33 consecutive patients (25 men; mean age +/- SD, 64 +/- 9.6 years) with solitary pulmonary nodules at different sites and with a lesion-to-pleura distance of at least 2 cm who previously underwent conventional bronchoscopy that did not result in histologic diagnosis. All patients were prospectively investigated with transbronchial bronchoscopic biopsy under MDCT guidance. Examinations were performed with the patient in conscious sedation using a low-dose protocol (80 kV, 20 mAs, 5-mm collimation, 10-mm slices). The position of the tip of the biopsy device was confirmed and documented before biopsies were performed. All specimens were examined by standard histopathologic techniques. The effective radiation dose was calculated for every patient. The diagnostic yield was 24 in 33 selected patients (overall accuracy, 72.7%): 13 (54%) had primary lung cancer and 11 (46%) had benign diagnoses. The formal operative characteristics were sensitivity, 59%; specificity, 100%; positive predictive value, 100%; and negative predictive value, 55%. The final diagnoses of the remaining nine patients in whom transbronchial bronchoscopic biopsy was not diagnostic were non-small cell lung cancer (n = 3); small cell lung cancer (n = 3); and alveolar carcinoma, carcinoid tumor, and hemorrhaged bulla (n = 1 each). All nonmalignant diagnoses were confirmed by 6 months radiographic and clinical follow-up. The mean duration of the procedure was 39 +/- 15 minutes, and the average effective dose was 0.7 mSv (range, 0.5-1.1 mSv). One case of pulmonary hemorrhage (3%) occurred after the procedure. MDCT-guided transbronchial bronchoscopic biopsy is a promising and safe tool for the diagnostic pathway of solitary pulmonary nodules in previously undiagnosed patients. Image quality was sufficient with low-dose protocols, which resulted in low radiation exposure for patients and personnel.

Real-World Cognitive--and Metacognitive--Dysfunction in Schizophrenia: A New Approach for Measuring (and Remediating) More "Right Stuff"

While the role of impaired cognition in accounting for functional outcome in schizophrenia is generally established by now, the overlap is far from complete. Moreover, little is known about the potential mechanisms that bridge between cognition and functional outcome. The aim of this article is to aid in closing this gap by presenting a novel, more ecologically valid approach for neuropsychological assessment. The new approach is motivated by the view that metacognitive processes of self-monitoring and self-regulation are fundamental determinants of competent functioning in the real world. The new approach incorporates experimental psychological concepts and paradigms used to study metacognition into current standard neuropsychological assessment procedures. Preliminary empirical data that support and demonstrate the utility of the new approach for assessment, as well as remediation efforts, in schizophrenia are presented and discussed.

Gene expression profiling in peripheral blood leukocytes as a new approach for assessment of human stress response

Stress is the coordinated physiological processes to maintain a dynamic equilibrium under stressful conditions. The equilibrium is threatened by certain physiological and psychological stressors. Stressors trigger physiological, behavioural, and metabolic responses that are aimed at reinstating homeostasis. The hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic nervous system play an essential role in the stress response. Excessive,prolonged, or inadequate response that is termed as "allostasis" or "allostatic load" leads to pathological outcomes. Dysregulation of the HPA axis activity is involved in the pathogenesis of stress-related disorders including major depression. The complex brain-immune-endocrine network regulates the HPA axis, and hereditary predisposition as well as environmental factors such as traumatic experiences in early life also modifies the capacity of an individual to cope. Therefore, it is difficult to correctly assess the complex stress response. We have developed a microarray carrying 1,467 cDNAs that were selected to specifically measure stress response in peripheral blood leukocytes. Using this tool, we have succeeded to objectively assess individual response to acute psychological stress and to detect unique expression profiles in patients with depression. Gene expression profile in peripheral blood leukocytes may be a potentially useful for the detection of disease-associated, abnormal stress responses.

New approaches for assessment of occupational exposure to metals using on-site measurements.

Traditional assessment of occupational exposure to metals typically involves static or personal aerosol sampling on a membrane filter followed by a laboratory determination of the metal content on the filter sample. These techniques give results with high accuracy and low detection limits. However, they all have a drawback in that, since the samples have to be analysed in a laboratory, the results will usually be obtained days or weeks after the sampling took place. Today there is available a new generation of portable electronic micro-balances and instruments for metal analysis based on X-ray fluorescence. These instruments will make on-site measurements of metal exposure possible, which opens the way for new approaches for assessment of occupational exposure to metals. In combination with high-flow pumps, short-term sampling is possible, which allows monitoring of the exposure variation during a work shift as well as the exposure during individual work tasks of short duration. Screening measurements and emission measurements are other examples of monitoring that are facilitated using on-site determinations. Measure control monitoring can effectively be performed using on-site measurements and is an effective tool in the assessment of workplace improvements. On-site determinations can also form an effective and pedagogic tool showing workers how to perform specific tasks and demonstrating the effectiveness of different measures intended to improve their work environment. Other examples are the assessment of skin exposure using aerosol deposition on pads and screening of contamination using bulk samples.