Nevus Lipomatosus Research Articles

Clinical, dermoscopic and histopathological features of solitary nevus lipomatosus cutaneous superficialis

Clinical, dermoscopic and histopathological features of solitary nevus lipomatosus cutaneous superficialis

Telocytes/CD34+ Stromal Cells in Pathologically Affected White Adipose Tissue

We studied telocytes/CD34+ stromal cells (TCs/CD34+SCs) in pathologically affected white adipose tissue after briefly examining them in normal fat. To this aim, we reviewed pathological processes, including original contributions, in which TCs/CD34+SCs are conserved, increased, and lost, or acquire a specific arrangement. The pathologic processes in which TCs/CD34+SCs are studied in adipose tissue include inflammation and repair through granulation tissue, iatrogenic insulin-amyloid type amyloidosis, non-adipose tissue components (nerve fascicles and fibres in neuromas and hyperplastic neurogenic processes) and tumours (signet ring carcinoma with Krukenberg tumour and colon carcinoma) growing in adipose tissue, adipose tissue tumours (spindle cell lipoma, dendritic fibromyxolipoma, pleomorphic lipoma, infiltrating angiolipoma of skeletal muscle and elastofibrolipoma), lipomatous hypertrophy of the interatrial septum, nevus lipomatosus cutaneous superficialis of Hoffman–Zurhelle and irradiated adipose tissue of the perirectal and thymic regions. Two highly interesting issues emerged: (1) whether the loss of CD34 expression in TCs/CD34+SCs is by changes in marker expression or the disappearance of these cells (the findings suggest the first possibility) and (2) whether in some invasive and metastatic malignant tumours, TCs/CD34+SCs that completely surround neoplastic cells act as nurse and/or isolating cells. Further studies are required on adipose tissue TCs/CD34+SCs, mainly in lipomatosis and obesity.

Cutaneous Eccrine Adenolipoma with a Spindle Cell Component

Abstract Introduction/Objective Cutaneous adenolipoma is a rare, benign variant of solitary lipoma characterized by a mature adipocytic proliferation with entrapped eccrine or apocrine sweat glands. It is found predominately in middle-aged females, with a predilection for lower extremities including the thigh and gluteal regions. Cutaneous adenolipoma is presumed to be a hamartomatous process. Herein, we report a unique case of a cutaneous eccrine adenolipoma with a spindle cell component, namely, an early evolving spindle cell adenolipoma. Methods A 43-year-old female with a recurrent history of hidradenitis presented with a 2.7 cm x 1.5 cm x 0.7 cm soft, mobile nodule on the right posterior thigh. It had been present for at least four months and clinically resembled a lipoma. An excisional punch biopsy was performed for pathological evaluation. A concurrent nevus lipomatosus superficialis was diagnosed from the right perineum. Results Gross examination of the thigh nodule revealed fragments of a tan-yellow, lobulated, fatty lesion. Microscopic examination demonstrated a benign lipomatous proliferation with entrapped eccrine glands associated with a surrounding spindle cell stroma. Initial differential diagnosis included a cutaneous eccrine adenolipoma variant and a cutaneous mixed solitary hamartoma composed of admixed neural, eccrine and lipomatous components. Immunohistochemical staining showed uptake for CD34 and CD10 in the spindle cell stromal component, but negative for desmin and S100. Based on our histopathological findings, our diagnosis of an eccrine cutaneous adenolipoma with a spindle cell component was rendered. This unique lesion displayed features of an evolving spindle cell lipoma with entrapped sweat glands, which may be viewed as an early stage of a dermal spindle cell adenolipoma. Conclusion Cutaneous eccrine adenolipoma is a rare, benign lipomatous neoplasm with entrapped sweat glands that can also show a spindle cell component. We share this rare lesion exemplifying the histomorphological spectrum of a lipomatous hamartoma and to highlight the recognition of a cutaneous adenolipoma.

Nevus Lipomatosus Cutaneous Superficialis

Nevus lipomatosus cutaneous superficialis (NLCS) is a rare, benign cutaneous hamartoma. It is characterized by the presence of mature adipose tissue aggregates among the dermal collagen bundles. While encountering a case of NLCS, differential diagnoses of neurofibroma, angiolipoma, lipomatosis, acrochordon, fibroepithelial polyp, nevus sebaceous and connective tissue nevus should be borne in mind and ruled out. Knowledge of this uncommon neoplasm would ensure early diagnosis and counselling regarding its benign nature to alleviate anxiety of patients.

Nevus Lipomatosus Cutaneous Superficialis: A Case Report and Literature Review

Introduction: Nevus lipomatosus cutaneous superficialis (NLCS) is uncommon and can be encountered in various medical specialties. In this study, we report a rare case of solitary pedunculated nevus lipomatosus cutaneous superficialis in a middle-aged female patient and highlight its clinical and histopathological features. Case Presentation: A 43-year-old Malaysian female patient presented to our center with a 2-cm long and 1-cm wide solitary, flesh-colored nodule over the anterolateral aspect of her thigh. Excisional biopsy was performed, and the histopathology report showed NLCS. There are three types of NLCS, namely the solitary, multiple, and generalized forms. The etiology of NLCS is usually idiopathic, with no gender or familial preponderance. NLCS is usually misdiagnosed and should be differentiated from nevus sebaceous, connective tissue nevus, neurofibroma, lymphangioma, hemangioma, and focal dermal hypoplasia (also known as Goltz syndrome). Conclusions: In conclusion, NLCS is rare and benign condition, which should be differentiated from other malignant skin conditions as it is commonly misdiagnosed. Therefore, physicians and surgeons should be aware of its clinical and histopathological features.

Nevus lipomatosus cutaneous superficialis (Hoffman-Zurhelle) over lower back: a rare presentation

<p>Nevus lipomatosus cutaneous superficialis is a rare benign local malformation of the skin characterized by ectopic adipocytes in the dermis. It presents as either a classical type known as Hoffman-Zurhelle or the solitary type. We report a case of the classical type with multiple soft, non-tender, cerebriform, skin-colored papules and nodules over the lower back in a 16 years old female.</p>

A case of nevus lipomatosus cutaneous superficialis complicated by fibrofolliculomas on the knee

A case of nevus lipomatosus cutaneous superficialis complicated by fibrofolliculomas on the knee

CT and MR imaging findings of solitary nevus lipomatosus cutaneous superficialis: radiological-pathological correlation.

This study assessed the CT and MRI findings of solitary nevus lipomatosus cutaneous superficialis (NLCS). Eleven patients with histopathologically and clinically confirmed solitary NLCS who underwent CT and/or MRI were enrolled. Radiological and histopathological findings of elevated lesions located above the level of the surrounding normal skin surface and coexisting subcutaneous lipoma-like lesions were assessed retrospectively. Elevated skin lesions were observed in all 11 patients; these lesions were pedunculated in 4 patients (36%) and broad-based in 7 (64%). The CT attenuation of elevated lesions was fat attenuation in 2 out of 7 patients (29%), slightly increased fat attenuation in 4 out of 7 (57%), and combined fat and soft-tissue attenuation in 1 out of 7 (14%). The MR signal intensity of elevated lesions on T1-weighted images was fat signal intensity in 2 out of 6 patients (33%), slightly decreased fat signal intensity in 3 out of 6 (50%), and combined fat signal intensity and hypointensity in 1 out of 6 (17%). Subcutaneous lipoma-like lesions with fat attenuation and/or fat signal intensity were observed in 6 out of 11 patients (55%). Histopathologically, various amounts of fatty tissue and collagenous fiber were observed within the elevated lesions in all 11 patients. The CT and MRI features of solitary NLCS were the broad-based or pedunculated elevated lesions, including fatty components. Additionally, subcutaneous lipoma-like lesions were frequently observed.

Laser treatment of epidermal nevi: A multicenter retrospective study with long-term follow-up

Patients with epidermal nevi strongly demand cosmetic improvement. Laser treatment appears appealing and is frequently used in clinical practice. Nevertheless, large series with long-term follow-up are missing, preventing definitive conclusions about its real benefit. To evaluate the long-term effectiveness and safety of lasers for epidermal nevi. Bicentric, retrospective, cohort study, including all patients treated with a laser for an epidermal nevus with more than a 1-year follow-up. Seventy patients were treated for different types of epidermal nevi, mostly with ablative lasers: 23 verrucous epidermal nevi, 16 nevi sebaceous, 26 Becker nevi, 2 inflammatory linear verrucous epidermal nevi, 1 smooth-muscle hamartoma, 1 rounded and velvety epidermal nevus, and 1 nevus lipomatosus superficialis. The follow-up period was a median of 37months (range, 12-127months). Better results, fewer recurrences, and higher patient satisfaction were noted in treatments for verrucous epidermal nevi than for nevi sebaceous. Q-switched lasers failed to show any degree of improvement in almost all patients with Becker nevus. The retrospective nature of the study. Ablative lasers can treat verrucous epidermal nevi with good long-term esthetic results but have limited long-term efficacy for nevus sebaceous. Q-switched lasers failed to improve Becker nevi.

Uncommon Elderly-Onset Nevus Lipomatosus Cutaneous Superficialis: A Case Report with Dermoscopic and Histopathologic Correlation

Uncommon Elderly-Onset Nevus Lipomatosus Cutaneous Superficialis: A Case Report with Dermoscopic and Histopathologic Correlation

Surgical Management of Multiple Nevus Lipomatosis Superficialis: A Case Report

Nevus lipomatosis superficialis is a rare skin lesion characterized by the ectopic dermal deposition of adipose tissue. While benign, it typically presents in the second to third decade of life as regional discomfort. We present the case of multiple lesions requiring serial surgical management.

Pedunculated nevus lipomatosus cutaneous superficialis of the scrotum successfully removed by excision

Nevus lipomatosis cutaneous superficialis is a rare cutaneous condition characterised by mature adipocytic hamartoma in the dermis amongst and splitting the collagen bundles. It was first reported in 1924. The first case report from India was in the year 1994. There is only 1 previous case report of the nevus occurring in the scrotum. The following case is reported for its rarity both in incidence and also the site involved. The lesion is asymptomatic and needs no treatment usually but since the lesion occupied a large area of scrotum we went ahead and did an excision of the nevus.

Solitary form of nevus lipomatosus cutaneous superficialis: A rare entity with review of literature

A 45-year-old female presented with a history of pedunculated, soft, nodule on the right leg in popliteal region for 5 years. The lesion started as a small nodule and increased in size for 2 years and remained unchanged thereafter. The histological examination confirmed ectopic mature adipose tissue within dermis that supported the clinical diagnosis of nevus lipomatosus. This case report is of a solitary form of nevus lipomatosis cutaneous superficialis or pedunculated lipofibroma.

Congenital Midline Nasal Anomalies

Congenital midline nasal anomalies are rare, with a prevalence of 1 in 20,000 to 40,000 births and with 5% to 7% of them being nasal glioma. Differential diagnoses of nasal anomalies include nasal dermoid cysts, gliomas, encephaloceles, nasal polyps, and some other rare anomalies. Due to current medical technological advancements, most of these anomalies are easily correctable, though delaying management may lead to fatal effects. This report describes two cases–one of nasal glioma and one of nevus lipomatosus cutaneous superficialis–that presented as respiratory distress in a newborn. Approximately 10 to 20 cases of these two conditions have been described; notably, this is the second documented case of nevus lipomatosus cutaneous superficialis with nasal presentation.

Nevo lipomatoso cutáneo superficial. Comunicación de 4 casos incluyendo una presentación inusual asociada a lipoma gigante y lipomatosis difusa

Nevus lipomatosus cutaneus superficialis is a rare, hamartomatous disorder, characterized by the presence of ectopic mature adipose tissue within the superficial dermis. Lesions occur within the first three decades of life. We report four new cases, including a patient with the most extensive affectation reported to date, which was associated with massive lipomas in the subcutaneous cell tissue and diffuse lipomatosis. To our knowledge, it is the first report of this disorder in Cuba.

Nevus Lipomatosus Cutaneous Superficialis with Unusual Presentation over the Nipple.

Nevus Lipomatosus Cutaneous Superficialis with Unusual Presentation over the Nipple.

A Case of Acquired Mucinous Nevus in Nevus Lipomatosus Cutaneous Superficialis.

A Case of Acquired Mucinous Nevus in Nevus Lipomatosus Cutaneous Superficialis.

Is nevus lipomatosus superficialis derived from pericyte around vessel?

Is nevus lipomatosus superficialis derived from pericyte around vessel?

Nevus Lipomatosus Cutaneous Superficialis: A Report of Two Cases.

Nevus Lipomatosus Cutaneous Superficialis: A Report of Two Cases.

A GIANT PERINEAL NEVUS LIPOMATOSUS SUPERFICIALIS: CASE REPORT

Nevus lipomatosus superficialis is a rare hamartomatous malformation which is composed of ectopic adipocytes in the dermis. It was first reported in 1921 by Hoffmann and Zurhelle. Two clinical forms of nevus lipomatosus superficialis have been described: classical (multiple) and solitary. Classical form of nevus lipomatosus superficialis is usually found on pelvic girdle, trunk, buttocks and thighs as soft, skin colored papules or nodules. It is usually present at birth or it appears in the first two decades of life. The solitary form of lipomatosus superficialis appears as a solitary papule or nodule on the back, scalp and arms of the patients with late onset. The lesions are usually asymptomatic, however some patients may complain about pain and itching. Malignant transformation of nevus lipomatosis superficialis has not been reported yet. Therefore, surgical intervention is only necessary for the patients who have cosmetic concerns. Recurrence after surgical removal is very rare. Perineum is an uncommon localization for nevus lipomatosus superficialis. Hereby, we report a 55-year-old Caucasian female with a 6x5,5x4 cm mass in the perineal region. The patient had cosmetic concerns, therefore she wanted the lesion to be removed surgically. The lesion was surgically removed. The histopathological evaluation of the specimen revealed nevus lipomatosus superficialis. A solitary type of giant nevus lipomatosus superficialis in the perineal region of a patient over the age of 50 is a very rare condition. Even rarely seen, nevus lipomatosus superficialis should be kept in mind in the differential diagnosis of perineal masses.