Value Of Neutrophil-to-lymphocyte Ratio In Patients Research Articles

Neutrophil- to- Lymphocyte Ratio as a Predictor of acute Appendicitis and Its Severity

Background: The Neutrophil-to-Lymphocyte Ratio (NLR) is an emerging biomarker for the diagnosis and severity assessment of acute appendicitis. This study evaluates the predictive value of NLR in patients undergoing appendicectomy.

The prognostic role of preoperative neutrophil-to-lymphocyte ratio in upper tract urothelial carcinoma.

The blood-based inflammatory marker, neutrophil-to-lymphocyte ratio (NLR), is a reliable prognostic biomarker for several cancers. Although the literature supports the correlation between preoperative NLR, clinicopathological characteristics, and oncological outcomes in upper tract urothelial carcinoma (UTUC), the cutoff of NLR is still debated. This study aimed to determine the prognostic value of NLR in patients with UTUC. This was a retrospective analysis of prospectively collected data from July 2012 to December 2022 evaluating patients with UTUC who underwent radical nephroureterectomy (RNU). NLR was calculated using the neutrophil and lymphocyte counts obtained a day before the surgery and the cutoff value was set as 2.5. Kaplan-Meier and Cox's proportional hazards regression were used to analyze the association between NLR and the oncological outcomes. The study included 91 patients (78 males, 13 females) in the final analysis with a median follow-up of 49 months (8-130). The mean age of the patients with NLR <2.5 and NLR ≥2.5 was 56.88 years and 56.35 years, respectively, and the pathological stage was pT1 in 48%, pT2 in 20.88%, pT3 in 27.47%, and pT4 in 3.30% of the patients. Multivariable Cox regression analysis showed that the preoperative NLR ≥2.5 was significantly associated (Hz = 7.17) with higher T stage, lymphovascular invasion, necrosis, nodal involvement, adjuvant chemotherapy, and worse overall survival (OS) (Hz = 9.87). The Kaplan-Meier analysis revealed an improved OS in patients with NLR <2.5, but a statistically significant difference in the recurrence-free survival was not found. Preoperative NLR is an easily available, inexpensive, and important prognostic biomarker of survival in patients with UTUC and has a potential role in risk stratification by predicting adverse clinicopathological characteristics.

Toplumdan Kazanılmış Pnömoni Hastalarında Prokalsitonin, C-Reaktif Protein, Kan Beyaz Küre Sayılarının ve Hemogram Alt Parametrelerinin Karşılaştırılması

Aims: Pneumonia is a clinically and radiologically detected inflammation of the lungs. Most of the pneumonia patients are community-acquired pneumonia cases. Hemogram and C-reactive protein (CRP) are commonly used to support diagnosis and follow-up of treatment. Procalcitonin is less accessible and expensive. And the use of hemogram subparameters is not very common. The aim of this study was to research the relationship between procalcitonin, CRP, White Blood Cell count (WBC) and hemogram subparameters in patients with CAP and the efficacy of new hematologic rates in differential diagnosis.&#x0D; Methods: Patients who were diagnosed with community acquired pneumonia by applying to the chest diseases outpatient clinic of our hospital were retrospectively analyzed. 67 patients who were clinically and radiologically diagnosed without noticing male or female were included in our study. Anamnesis data and co-morbidities of the cases were questioned. Procalcitonin, CRP and hemogram (platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and monocyte-to-lymphocyte ratio (MLR) were calculated and WBC value was examined) were recorded. The obtained data were evaluated statistically and compared in terms of variables. &#x0D; Results: The mean age of our patients was 57 (18-71) years; there were 41 (61.19%) female and 26 (38.81%) male patients. 36 (53.73%) of our patients had chronic diseases; 21 (31.34%) had heart disease, 23 (34.32%) had diabetes, and 6 (8.95%) had kidney failure. Patients; 48 (71.64%) procalcitonin, 56 (83.58%) CRP, 38 (56.71%) WBC, 52 (77.61%) NLR, 34 (50.74%) PLR and 38 (56.71%) MLR values were high. Procalcitonin, CRP and NLR values were significantly higher than other subparameters. The CRP and NLR values of patients with an additional chronic disease were higher than patients without co-morbidities. In the correlation analyses, there was a strong correlation between procalcitonin, CRP and NRL, but the correlation between the others was not significant. (p

Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients Treated with Definitive Chemoradiotherapy for Locally Advanced Oesophageal Squamous Cell Carcinoma.

The neutrophil-to-lymphocyte ratio (NLR) has been shown to have prognostic value in several common cancers. This study aimed to investigate the prognostic value of NLR in patients with advanced oesophageal squamous cell carcinoma (ESCC) after definitive chemoradiotherapy (dCRT). A retrospective analysis was performed on 158 patients with advanced ESCC who received dCRT from January 2012 to December 2018. The NLR for different treatment stages was calculated based on laboratory test results. The Kaplan-Meier (KM) method and Cox proportional regression model were used to analyse the relationship between NLR and overall survival (OS). The mean NLR of 158 patients with ESCC was 3.403 ± 2.479. The pre-treatment NLR cut-off was 4.839, and patients were divided into the low NLR group (NLR < 4.839) and the high NLR group (NLR ≥ 4.839). NLR in patients with ESCC was related to N stage (P < 0.05). The KM analysis showed that the median OS of all enrolled patients was 29.3 months, the median OS periods of patients in the high and low NLR groups were 15.6 and 35.8 months, respectively, and the OS of the low NLR group was better than that of the high NLR group (P < 0.001). In the multivariate analysis, NLR was an independent prognostic factor that affects the prognosis of patients with ESCC receiving dCRT. Furthermore, patients who maintained a high NLR before and after treatment showed worse clinical outcomes than the other groups. Our findings suggest that NLR can effectively assess the prognosis of patients with advanced ESCC undergoing dCRT.

Neutrophil-to-lymphocyte ratio is a potential prognostic biomarker for extramammary Paget disease: A retrospective study.

The neutrophil-to-lymphocyte ratio (NLR) is a useful prognostic biomarker for many cancer types. However, the prognostic value of NLR in patients with extramammary Paget disease (EMPD) remains unclear. This study aimed to determine whether NLR is associated with overall survival (OS) in patients with EMPD. In this single-center retrospective case series, we analyzed data of 109 patients with previously untreated EMPD who presented to our hospital. Data on age, sex, primary tumor site, invasion level, presence of lymph node and distant metastases, baseline NLR, and OS were analyzed. The enrolled patients were classified into the metastatic or non-metastatic EMPD groups. The metastatic EMPD group had higher invasion level and NLR value (p< 0.001 and p= 0.005, respectively) compared with the non-metastatic EMPD group. Cox proportional hazards model analysis showed invasion level (p= 0.0093) and NLR value (p= 0.019) to be independent prognostic factors for OS. Notably, multivariate analysis revealed that invasion level (p= 0.045) and NLR value (p= 0.036) were independent prognostic factors for OS in the metastatic EMPD group. The limitations of this study include the small number of participants and its retrospective nature. In conclusion, since NLR can be routinely assessed with high feasibility, it might be a useful biomarker for predicting prognosis in patients with EMPD.

Dynamics of neutrophil-to-lymphocyte ratio predict outcomes of metastatic colorectal carcinoma patients treated by FOLFOX.

Peripheral blood cell count is the most common clinical laboratory test. Neutrophil-to-lymphocyte ratio (NLR) as an economic marker has been reported in various cancer types. It is believed that NLR is associated with the prognosis and treatment outcomes of some cancers. Low baseline NLR has been reported as associated with better overall survival (OS) in advanced cancer patients. In this study, we aimed to determine whether the changes of NLR may predict the outcome of metastatic colorectal carcinoma (mCRC) patients treated with folinic acid, fluorouracil, and oxaliplatin (FOLFOX) combined with bevacizumab/cetuximab. The clinical data obtained from 128 mCRC patients between January 2014 and December 2018 were retrospectively analyzed. The NLR values of patients were calculated after 4 cycles of treatments. Kaplan-Meier analysis and Cox regression modeling were performed to assess the impact of NLR dynamics on OS and progression-free survival (PFS). Among the 128 participants, the optimum pre-treatment NLR cutoff value was 3. A total of 70 (54.7%) participants had a pre-treatment of NLR lower than 3. The median of PFS was 9.1 months for NLR <3 compared with 6.1 months for pre-treatment NLR >3. A lower pre-treatment NLR was significantly associated with better PFS (P<0.001), but not associated with OS (P=0.064). A total of 94 (73.4%) participants had a post-treatment NLR <3, which was associated with better PFS and OS (P=0.007). However, changes in NLR significantly affected PFS and OS. Decrease in post-treatment NLR was associated with longer PFS and OS. Patients with changes from low pre-treatment NLR to high post-treatment NLR had worse OS and PFS than that of NLR changes from high to low. It is not the NLR but the changes of NLR that may predict the efficacy of FOLFOX treatment in mCRC patients.

Peripheral blood neutrophil-to-lymphocyte ratio in inflammatory bowel disease and disease activity: A meta-analysis

ObjectiveThe peripheral blood neutrophil-to-lymphocyte ratio (NLR) is a valuable predictor of clinical disease activity in inflammatory bowel disease (IBD). Therefore, we conducted a meta-analysis to evaluate the clinical significance of peripheral blood NLR in IBD patients. MethodsA comprehensive literature search was conducted by searching PubMed, Embase, Web of Science, Cochrane Library, and Chinese databases from inception to May 10, 2021. We used the standard mean difference (SMD) with a 95% confidence interval (CI) to estimate the pooled effect and subgroup analysis to investigate heterogeneity. ResultsSixteen studies including 2185 IBD patients and 993 healthy controls (HCs) were enrolled in this study. The peripheral blood NLR values were significantly higher in 1,092 IBD patients than in 933 HCs (SMD = 1.54, 95% CI = 1.05–2.02, P < 0.001) and in 1,269 patients with active IBD than in 1,056 patients with remissive IBD (SMD = 1.55, 95% CI = 1.06–2.05, P < 0.001). Subgroup analysis of the major subtypes of IBD revealed significantly elevated peripheral blood NLR values in patients with active ulcerative colitis (UC) compared to HCs (SMD = 2.04), remissive UC than HCs (SMD = 0.63), and active UC than in those with remissive UC (SMD = 1.32) (P < 0.05). Both Crohn’s disease (CD) patients and active CD patients had significantly elevated peripheral blood NLR values than HCs with the SMD of 0.52 and 3.53 (P < 0.001). ConclusionsPeripheral blood NLR could serve as a valuable biomarker for predicting disease severity in IBD patients.

Do platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) have a predictive value on pediatric extracorporeal membrane oxygenation (ECMO) results?

It is difficult to predict the complications and prognosis of ECMO, which is gaining widespread use in patients with pediatric surgery. Platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) are emerging inflammatory markers that can be calculated from complete blood count, which is a cheap and easily accessible laboratory analysis. The ratios between cellular elements in peripheral blood have been demonstrated to provide information on inflammation, infection, and immune response. Sixty-seven patients who needed ECMO application after undergoing pediatric cardiovascular surgery in our clinic, between May 2005 and April 2020, were included in this study. The age of patients varied between 4 days and 17 years with a mean of 30.59±147.26 months. The relationships between PLR or NLR values and various blood parameters and blood gas results were found to be statistically nonsignificant in our group of pediatric ECMO recipients. Even if the effect of PLR and NLR values on mortality and prognosis is statistically nonsignificant in patients who need ECMO after congenital heart surgery, PLR and NLR are typically elevated in the postoperative period. An increase in these values above a certain threshold may be a statistically significant indicator for the prediction of mortality. There are few studies in the literature concerning PLR and NLR values in patients with pediatric heart surgery. We consider this study will make way for new studies in the future.

Neutrophil to Lymphocyte Ratio Predicts Outcome of Stroke by Cervicocranial Arterial Dissection.

Background and Purpose: Neutrophil to lymphocyte ratio (NLR) is positively associated with poor prognosis in patients with cerebral infarction. The goal of this prospective study is to explore the predictive value of NLR in patients with acute ischemic stroke (AIS) caused by cervicocranial arterial dissection (CCAD).Methods: Ninety-nine patients with AIS caused by CCAD met criteria for inclusion and exclusion were selected for this study. We collected baseline data on the admission including NLR. The primary poor outcome was major disability (modified Rankin Scale score ≥ 3) or death at 3 months after AIS.Results: A total of 20 (20.2%) patients had a poor outcome at 3 months after AIS. According to the 3-month outcome, the patients were divided into two groups and univariate and multivariable analyses were conducted. Among the risk factors, elevated NLR levels were independently associated with 3-month poor outcomes. Further, we made the ROC curve to evaluate the predictive value of NLR level on prognosis. The area under the curve was 0.79 and a cut-off value of NLR was 2.97 for differentiating the poor outcome. We divided patients into groups according to the cut-off value. Patients with high NLR have a higher risk of poor outcome than those with low NLR (P < 0.05).Conclusion: As an inflammatory marker, elevated NLR levels were associated with 3-month poor outcome in AIS caused by CCAD.

The neutrophil to lymphocyte ratio as a novel predictor of asthma and its exacerbation: a systematic review and meta-analysis.

It is widely known that the main white blood cell populations, and neutrophil to lymphocyte ratio (NLR), are involved in systemic inflammation. The usefulness of NLR measurements has been reported in patients with asthma. We performed a systematic review and meta-analysis of studies to investigate the relationship between the NLR and asthma and its exacerbations. We systematically searched PubMed and Embase databases for studies (published between Jan 1, 1950 and Jan 2, 2020; no language restrictions) comparing the NLR values in patients with stable asthma or asthma exacerbations to healthy controls. We assessed pooled data by use of a random-effects model. Of 260 identified studies, 6 were eligible and were included in our analysis (N = 2418 participants). Compared with 439 healthy controls, 743 stable asthma patients in four studies showed significantly greater NLR values (standardized mean difference, SMD, 0.567, 95% CI 0.212-0.922; p = 0.002). Furthermore, compared with 1063 stable asthma patients, 402 asthma exacerbation patients yielded significantly greater NLR values (random effects SMD 1.335, 95% CI 0.429-2.241; p < 0.001). Our meta-analysis showed that the NLR values are a reasonable and easy-to-use marker for asthma and its exacerbations. Further studies, with larger sample sizes and more phenotypes, are required to establish its use as a predictive parameter in asthma.

Sensitivity Comparison of Pleural Fluid and Serum Neutrophil to Lymphocyte Ratio (NLR) Values in Exudative Pleural Effusion Patients

Background: Delay in diagnosis and non-compliance to tuberculosis (TB) treatment will increase the risk of MDR TB. WHO recommends GeneXpert as a diagnostic tool, however, the availability is still an obstacle and this tool is not owned by many health facilities. The Neutrophil-Lymphocyte Ratio (NLR) value was thought to be used to estimate the likelihood of TB cases. This study aimed to assess the sensitivity comparison of pleural fluid and serum NLR values in patients with pleural effusion at H. Adam Malik Medan General Hospital. Methods: This was an analytical study with a diagnostic test design, by calculating the sensitivity and specificity of pleural fluid and serum NLR. The sample was calculated by comparing the absolute neutrophil count and the absolute lymphocyte count from both pleural fluid and serum. Results: The sample of this study was 78 patients. In this study, pleural fluid NLR with a cut off value of 2.2 showed a sensitivity of 74% and specificity of 28%, whereas serum NLR with a cut off value of 7.0 produced a sensitivity of 53% and specificity of 68%. Conclusion: The sensitivity of pleural fluid NLR was greater than that of serum, while the specificity of serum NLR was more superior than that of pleural fluid.

LDGs versus NDGs in patients with oral squamous cell carcinoma (OSCC)

BackgroundThe significant role played by neutrophils in cancer biology is indisputable; yet, their subpopulations may exhibit a contrasting role. The phenomenon of polarization of neutrophils and signaling modulators in the course of a neoplastic process has gained increased attention in recent times.The present study's objective was to quantitatively assess low-density neutrophils (LDNs) and normal-density neutrophils (NDNs) populations including IL-17 expression in confrontation with Th17 lymphocytes in patients with oral squamous cell carcinoma (OSCC). The neutrophil to lymphocyte ratio (NLR) biomarker value was determined. Besides, the influence of rhIL-17 on the proliferation level of the squamous cell carcinoma (SCC) malignant line cells was tested. MethodsLeukocytes were isolated in the density gradient and the CD16+ population was magnetically sorted. The percentages of neutrophil subpopulations, lymphocyte Th17, and IL-17 expression in the studied cells were determined on a flow cytometer. Squamous cell carcinoma proliferation was assessed with the MTT test. ResultThe existence of two populations of human neutrophils was determined: LDNs and NDNs. A higher percentage of LDNs and Th17 was observed with the concomitant lower percentage of NDNs in patients with OSCC as compared with the control group. NLR was elevated in patients with cancer. The highest IL-17 expression was obtained in the LDNs population in these patients. However, no influence of IL-17 on SCC proliferation could be determined. ConclusionThe present study demonstrated a strong relationship between IL-17 concentration and the count of LDNs or Th17 in the course of OSCC, which may serve as a reference point for new therapies. Moreover, the obtained LDNs/NDNs and NLR values in patients with cancer prove their usefulness in diagnostic and prognostic in patients with OSCC.

Neutrophils to Lymphocyte Ratio as a Biomarker in Bronchiectasis Exacerbation: A Retrospective Study.

IntroductionBronchiectasis is a disorder resulting mainly from bronchial inflammation caused by recurrent or chronic infections. It is characterized by permanently dilated airways due to bronchial wall destruction. Exacerbations have a key role in bronchiectasis as they are associated with a negative impact on patient prognosis. Exacerbations are generally infectious events caused mostly by bacterial microorganisms. Infective or inflammatory agents cause neutrophil recruitment into the airways, which leads to proteolytic enzymes such as neutrophil elastase and matrix metalloproteinases release, resulting in airway matrix destruction. Neutrophil to lymphocyte ratio (NLR) is used as a biomarker of inflammation. It is calculated by dividing the number of neutrophils by the number of lymphocytes. Our aim is to evaluate Neutrophils to Lymphocyte Ratio in patients with bronchiectasis exacerbation and its correlation to microbiological data.Methods The study involved patients with a diagnosis of bronchiectasis based on high-resolution computerised tomography (HRCT) of the chest who fulfilled the criteria of bronchiectasis exacerbation. Complete blood counts with differential counts, which included total white blood cells, neutrophils and lymphocytes, were obtained. NLR and C-reactive protein (CRP) levels were measured in patients with bronchiectasis exacerbation and in healthy controls. NLR was calculated as the ratio of the neutrophils to lymphocytes. The mean NLR values in patients with bronchiectasis exacerbation were compared to mean NLR values in healthy controls. The NLR values were compared to CRP levels in patients with bronchiectasis exacerbation. Sputum cultures were performed in all patients. The mean NLR values in patients with positive sputum cultures were compared with mean NLR values in patients with negative sputum cultures, and mean NLR values in patients with isolated Pseudomonas aeruginosa in sputum cultures were compared to mean NLR values in patients with other infectious agents isolated.ResultsThe study population consisted of 80 patients with bronchiectasis exacerbation - 54 males and 26 females - with a mean age of 77.3±8.4 years, and 64 healthy controls - 36 males and 28 females - with a mean age of 62.9±15.3 years. The mean CRP levels in patients with bronchiectasis exacerbation were 75.03±73.87 mg/l. The mean NLR value in patients with bronchiectasis exacerbation was 9.2±7.8 and the mean NLR value of controls was 3.1±2.9 (p<0.001). The NLR values in patients with bronchiectasis exacerbation had no linear correlation with CRP values in these patients (r=0.002, p=0.992). Fifty-two patients had positive sputum cultures and 28 patients had negative sputum cultures. The mean NLR value in patients with positive sputum cultures was 10.5±9.1, and in patients with negative sputum cultures, it was 6.7±3.6 (p<0.012). The mean NLR value in patients with P.aeruginosa was 10.1±9.5, and in patients with other microorganisms isolated, it was 10.8±8.9 (p=0.784).ConclusionsNeutrophil to lymphocyte ratio values are statistically greater in patients with bronchiectasis exacerbation compared to healthy controls. There is no linear correlation between NLR and CRP in these patients. NLR values are statistically greater in patients with positive sputum cultures compared to those with negative sputum cultures. Therefore, NLR can be used for predicting positive cultures in patients with bronchiectasis exacerbation.

Peri-interventional Behavior of the Neutrophil to Lymphocyte Ratio in Patients with Intracranial Aneurysms

The neutrophil-to-lymphocyte ratio (NLR) has been investigated as an independent predictive marker for clinical outcomes in vascular diseases. This study aimed to investigate the peri-interventional behavior of the NLR in patients with ruptured and unruptured intracranial aneurysms (IAs). A total of 117 patients with IAs, who were treated at our department and had available complete data, were retrospectively identified during a 10-year period. Routine laboratory parameters, including the neutrophil and lymphocytes counts, were evaluated before and after treatment. The baseline NLR showed significant differences between patients with ruptured and unruptured IAs (6.3 vs. 1.8; P < 0.001). In patients with ruptured IAs, the baseline NLR decreased significantly during the follow-up visits, whereas in unruptured IAs, the NLR remained low. Furthermore, higher baseline NLR values could also be observed in patients with ruptured IAs and fatal outcome than in surviving patients (8.0 vs. 5.4; P= 0.220). In patients with poor functional outcome, defined as modified Rankin score ≥3, the NLR was significantly higher before treatment (P= 0.047), at day 10 (P= 0.025), and 1 month after treatment (P= 0.001). The peri-interventional NLR was significantly different between patients with ruptured and unruptured IAs. In patients with ruptured IAs, elevated baseline NLR levels were associated with poor postoperative functional outcomes and decreased postoperatively, implying the potential prognostic value of NLR in patients with IAs.

Dynamic Alteration of Neutrophil-to-Lymphocyte Ratio over Treatment Trajectory is Associated with Survival in Esophageal Adenocarcinoma.

Neutrophil-to-lymphocyte ratio (NLR) has been identified as a biomarker for multiple malignancies. There is emerging evidence that implicates neutrophils in cancer progression. Alterations of neutrophil counts and NLR during treatment may reflect a change in oncologic outcome that is more important than baseline values. The aim of this study is to investigate the prognostic role of NLR changes during the treatment trajectory of patients with esophageal adenocarcinoma. NLR values of patients with esophageal adenocarcinoma who underwent surgery between 2005 and 2016 were measured at baseline and in the late postoperative period. Primary outcomes were overall survival (OS) and disease-free survival (DFS). The secondary outcome was pathological response to neoadjuvant chemotherapy. 330 patients were included; mean age was 65.6years, and 82% were male. Most patients had cT3 (74.8%), cN-positive (59.7%) disease. Two-thirds (65.2%) received neoadjuvant chemotherapy. The independent predictors of OS were pathological N-stage, size of primary tumor, and delta NLR (late - baseline NLR). Patients with persistently elevated NLR did worse than those with decreasing NLR trends between baseline and postoperative time points (3-year OS 43.4% versus 71.3%, p < 0.0001, 3-year DFS 29.7% versus 61.9%, p < 0.0001). High baseline and postoperative NLR were associated with significantly worse OS and DFS. Patients with complete pathological response had lower mean baseline NLR. Dynamic changes in NLR during treatment are associated with survival and may be more informative than static baseline values.

Neutrophil to Lymphocyte Ratio in Patients with End Stage Renal Disease in Benue State University Teaching Hospital, Makurdi, Nigeria

Chronic Kidney Disease (CKD) leads to end-stage renal disease (ESRD) and cardiovascular events. An important determinant of progression in CKD is chronic systemic inflammation which can be evaluated using the neutrophil to lymphocyte ratio (NLR). We aimed to investigate the value of NLR in patients with ESRD compared with healthy subjects. This was a retrospective study that analyzed data from patients with end-stage renal disease and equal number of age and sex matched control (healthy subjects) seen at Benue State University Teaching Hospital Makurdi from October 1st, 2012 to 31st December 2015. Out of the 118 patients studied 70(59.3) were males while 48 (40.7) were females. The mean age of the study population was 45.9 ± 16.4. The mean NLR for patients with ESRD was 3.55± 4.01 while that of healthy subjects was 1.29± 0.25. The mean NLR for patients was 3.47±4.01 for males and 3.68±4.06 for females while for the healthy subjects the mean NLR was 1.30±0.27 for males 1.27±0.22 for females. This study revealed elevated NLR in patients with ESRD. NLR reflects systemic inflammation. The availability of this ratio (NLR) can help improve outcome of patients with CKD.

Neutrophil to Lymphocyte Ratio in Patients with End Stage Renal Disease in Benue State University Teaching Hospital, Makurdi, Nigeria

Chronic Kidney Disease (CKD) leads to end-stage renal disease (ESRD) and cardiovascular events. An important determinant of progression in CKD is chronic systemic inflammation which can be evaluated using the neutrophil to lymphocyte ratio (NLR). We aimed to investigate the value of NLR in patients with ESRD compared with healthy subjects. This was a retrospective study that analyzed data from patients with end-stage renal disease and equal number of age and sex matched control (healthy subjects) seen at Benue State University Teaching Hospital Makurdi from October 1st, 2012 to 31st December 2015. Out of the 118 patients studied 70(59.3) were males while 48 (40.7) were females. The mean age of the study population was 45.9 ± 16.4. The mean NLR for patients with ESRD was 3.55± 4.01 while that of healthy subjects was 1.29± 0.25. The mean NLR for patients was 3.47±4.01 for males and 3.68±4.06 for females while for the healthy subjects the mean NLR was 1.30±0.27 for males 1.27±0.22 for females. This study revealed elevated NLR in patients with ESRD. NLR reflects systemic inflammation. The availability of this ratio (NLR) can help improve outcome of patients with CKD.

Neutrophil to Lymphocyte Ratio in Patients with End Stage Renal Disease in Benue State University Teaching Hospital, Makurdi, Nigeria

Chronic Kidney Disease (CKD) leads to end-stage renal disease (ESRD) and cardiovascular events. An important determinant of progression in CKD is chronic systemic inflammation which can be evaluated using the neutrophil to lymphocyte ratio (NLR). We aimed to investigate the value of NLR in patients with ESRD compared with healthy subjects. This was a retrospective study that analyzed data from patients with end-stage renal disease and equal number of age and sex matched control (healthy subjects) seen at Benue State University Teaching Hospital Makurdi from October 1st, 2012 to 31st December 2015. Out of the 118 patients studied 70(59.3) were males while 48 (40.7) were females. The mean age of the study population was 45.9 ± 16.4. The mean NLR for patients with ESRD was 3.55± 4.01 while that of healthy subjects was 1.29± 0.25. The mean NLR for patients was 3.47±4.01 for males and 3.68±4.06 for females while for the healthy subjects the mean NLR was 1.30±0.27 for males 1.27±0.22 for females. This study revealed elevated NLR in patients with ESRD. NLR reflects systemic inflammation. The availability of this ratio (NLR) can help improve outcome of patients with CKD.

Neutrophil to Lymphocyte Ratio in Patients with End Stage Renal Disease in Benue State University Teaching Hospital, Makurdi, Nigeria

Chronic Kidney Disease (CKD) leads to end-stage renal disease (ESRD) and cardiovascular events. An important determinant of progression in CKD is chronic systemic inflammation which can be evaluated using the neutrophil to lymphocyte ratio (NLR). We aimed to investigate the value of NLR in patients with ESRD compared with healthy subjects. This was a retrospective study that analyzed data from patients with end-stage renal disease and equal number of age and sex matched control (healthy subjects) seen at Benue State University Teaching Hospital Makurdi from October 1st, 2012 to 31st December 2015. Out of the 118 patients studied 70(59.3) were males while 48 (40.7) were females. The mean age of the study population was 45.9 ± 16.4. The mean NLR for patients with ESRD was 3.55± 4.01 while that of healthy subjects was 1.29± 0.25. The mean NLR for patients was 3.47±4.01 for males and 3.68±4.06 for females while for the healthy subjects the mean NLR was 1.30±0.27 for males 1.27±0.22 for females. This study revealed elevated NLR in patients with ESRD. NLR reflects systemic inflammation. The availability of this ratio (NLR) can help improve outcome of patients with CKD.

Neutrophil to Lymphocyte Ratio in Patients with End Stage Renal Disease in Benue State University Teaching Hospital, Makurdi, Nigeria

Chronic Kidney Disease (CKD) leads to end-stage renal disease (ESRD) and cardiovascular events. An important determinant of progression in CKD is chronic systemic inflammation which can be evaluated using the neutrophil to lymphocyte ratio (NLR). We aimed to investigate the value of NLR in patients with ESRD compared with healthy subjects. This was a retrospective study that analyzed data from patients with end-stage renal disease and equal number of age and sex matched control (healthy subjects) seen at Benue State University Teaching Hospital Makurdi from October 1st, 2012 to 31st December 2015. Out of the 118 patients studied 70(59.3) were males while 48 (40.7) were females. The mean age of the study population was 45.9 ± 16.4. The mean NLR for patients with ESRD was 3.55± 4.01 while that of healthy subjects was 1.29± 0.25. The mean NLR for patients was 3.47±4.01 for males and 3.68±4.06 for females while for the healthy subjects the mean NLR was 1.30±0.27 for males 1.27±0.22 for females. This study revealed elevated NLR in patients with ESRD. NLR reflects systemic inflammation. The availability of this ratio (NLR) can help improve outcome of patients with CKD.