For PWR whole-core pin-by-pin neutronics/thermal-hydraulics (Nu-TH) coupling analysis, the Picard iteration strategy is widely employed benefitting from the convenience of implementation. Nevertheless, it is limited to the global multi-physics convergence rate regarding its oscillatory convergence behaviors in the local solution of each single-physics field. In this paper, the Anderson Acceleration (AA) scheme is employed and investigated to enhance the convergence performance of the pin-by-pin Nu and subchannel TH coupling analysis code NECP-Bamboo2.0. Different from the classical relaxation scheme where the relaxation factor is predetermined and fixed, the AA scheme utilizes the linear combination of several previous solutions to correct the current solution. The coefficients of this linear combination can be obtained by solving the residual equation, making the approach more robust. In addition, the selection of the accelerated solution vector is investigated based on the tightly coupling strategy of Nu-TH in NECP-Bamboo2.0. It is illustrated that the neutron-transport solution vector could have superior theoretical acceleration performance compared to the commonly used TH solution vector in the practical PWR analysis scenario. Finally, the AA scheme in NECP-Bamboo2.0 is validated using the VERA#6 3D single-assembly transport/TH coupling benchmark problem and the VERA#7 3D whole-core multi-physics coupling benchmark. It is demonstrated by the numerical results that the AA scheme possesses good robustness and computational efficiency. For the 3D whole-core VERA#7 benchmark, compared with the classic Picard iteration with a relaxation factor of 0.5, the AA scheme based on the neutron-transport solution vector can reduce the number of global iterations and calculation time by around 80%.