In this work cubic phase, silicon carbide nano-powders were irradiated at the high-flux pulsed reactor IBR–2 (Dubna, Russia). The 3C–SiC powder was irradiated with neutron doses up to 1015 n/cm2. The irradiated samples were then analyzed using X-ray diffraction, Raman spectroscopy, Positron annihilation spectroscopy, and Fourier Transform Infrared Spectroscopy. The XRD analysis showed a slight decrease in the lattice parameters with the increase in neutron fluences. The results obtained from positron annihilation measurements were compared to the theoretical calculations, to recognizing the type of structural defect in the samples. A positron lifetime component 355 ps associated with the calculated values for clusters containing of 13–21 vacancies was identified. The concentration of these defects was estimated to be in the region of 5 ppm, and was very similar to the one identified on the unirradiated sample. The results also indicate high irradiation resistivity of the 3C–SiC after irradiation.