The present article deals with the application of refined plate theory and surface effects to investigate the nonlocal free vibration behavior of a functionally graded nano-plate composed of two piezoelectric face sheets resting on Orthotropic Visco-Pasternak. Surface and nonlocal effects are applied using the surface piezoelectricity and stress-strain gradient theories. Surface effects, refined quasi-3D higher-order theory, neutral surface position and in-plane mechanical preloads are considered to study piezoelectric sandwich nano-plate with a functionally graded core in this study for the first time, simultaneously. The size-dependent governing equations are derived based on 2D and 3D refined theory using Hamilton’s principle and different boundary conditions are studied and investigated according to the semi-analytical solution method. Comparing the results of the vibration behavior of 2D and quasi-3D models, local and non-local models, and also, examining different foundations simultaneously can be said as one of the innovations of the current research. Finally, a parametric study is presented to examine the effects of different parameters such as surface effects, small scale parameters, mechanical preloads, thickness stretching effects, neutral surface position, non-homogeneous coefficient, applied voltage, different foundation constants, boundary conditions, geometrical ratios and different theories in details. It is indicated that the inclusion of surface effects and thickness stretching effects leads to a significant influence on the vibration behavior of three-layered nano-scale plates. The presented results in this article may provide useful guidance for the design and development of the next generation of nano-devices.