The neurosurgery service at the Hospital for Sick Children began with the appointment of Dr. William S. Keith (1902–1987) in 1933 [1]. Dr. Keith had trained in Surgery in Toronto, and had received specialty training with Percival Bailey and Paul Bucy in Chicago, and at the National Hospital for Neurological Disorders at Queen’s Square in London, England. He was the sole appointee and neurosurgeon for children with neurosurgical disorders in Toronto, and Ontario for nearly 21 years. Dr. Keith was joined by Dr. E Bruce Hendrick in 1954 after he had obtained subspecialty training in pediatric neurosurgery in Boston under the tutelage of Dr. Franc Ingraham and Dr. Donald Matson. Dr. Hendrick was Neurosurgeon-in-Chief from 1964 until 1986, and was one of the founders of the International Society of Pediatric Neurosurgery (ISPN). He died in 2001 from complications relating to ruptured diverticulitis. In his name and honor, the annual E. Bruce Hendrick Lectureship has been established at Sick Kids. Dr. Harold J. Hoffman was appointed to the neurosurgical Staff at Sick Kids in 1964. He was a prolific author with over 200 peer-reviewed articles, and an authority on tethered cord, craniopharyngioma, epilepsy surgery, and Chiari malformation. Dr. Hoffman marveled at and acquired many new technologies that kept Sick Kids neurosurgery ahead of the curve for complex neurosurgical procedures. He was quick to use neuronavigation, the cavitron and laser. He also designed theHoffman T-tube shunt for lumboperitoneal shunts, and a “unishunt” designedwith his close colleague and friend, Dr. Fred Epstein. During his career, Dr. Hoffman was President of the American Society of Pediatric Neurosurgery (ASPN), President of the ISPN, and President of the Canadian Neurosurgical Society. He was Neurosurgeon-in-Chief at Sick Kids from 1986 to 1996. In his name and honor, upon retirement in 1998, the Harold J Hoffman/Shoppers Drug Mart Chair in Pediatric Neurosurgery was established at Sick Kids. Dr. Hoffman died in 2004 after fighting a dementing illness for several years. Dr. Robin P. Humphreys joined the neurosurgical staff at Sick Kids in 1970. He initiated the Craniofacial Program at Sick Kids with Dr. Ian Munro, and over the years became a world authority on the management of children with spina bifida and vascular malformations. He was President of the ASPN from 1992 to 1993, and of the ISPN from 1993 to 1994. Dr. Humphreys was Neurosurgeon-in-Chief at Sick Kids from 1996 to 2003. In his name, the Robin and Judith Humphreys lectureship at Sick Kids has been established, and is given by the graduating chief fellow annually. It is difficult to describe the magnitude of the numerous contributions made by Drs. Hendrick, Hoffman, and Humphreys, who were collectively referred to as the “3 H’s”worldwide. They were frequently cited on each other’s written works, and together they wrote many of the seminal textbooks and articles which have helped shape the field of pediatric neurosurgery to the present day. The next generation of pediatric neurosurgeons at Sick Kids began in 1988 with the appointment of James Drake, and in 1990 of James Rutka. The “two Jims” brought an element of research to the neurosurgery service as Jim Drake pursued interests in bioengineering, and Jim Rutka established the first brain tumor research laboratory. They were followed in sequence by Peter Dirks in 1998, Abhaya Kulkarni in 2003, and Michael Taylor in 2004. Paediatric Neurosurgery at SickKids Dr. E. Bruce Hendrick