Journal Of Neuroscience Research Articles

A new circuit underlying the renewal of appetitive Pavlovian responses: Commentary on Brown and Chaudhri (2022).

A new circuit underlying the renewal of appetitive Pavlovian responses: Commentary on Brown and Chaudhri (2022).

A bibliometric analysis: Current status and frontier trends of Schwann cells in neurosciences.

This review aims to present a comprehensive bibliometric analysis related to Schwann cells (SCs) in neurosciences from 2012 to 2021. We used the Web of Science core collection database to obtain publications on SCs in the field of neurosciences from 2012 to 2021. The obtained data were further visually analyzed by using CiteSpace, VOSviewer, and an online bibliometric platform. We retrieved a total of 1,923 publications related to SCs in neurosciences. The number of publications in this field fluctuates steadily each year, and the number of citations is increasing year by year. The United States is leading the field, with LERU and the University OF London as influential institutions, Jessen KR and Feltri ML as the most representative authors, and GLIA and JOURNAL OF NEUROSCIENCE as authoritative journals in the field. Meanwhile, we predict that a more in-depth study of autophagy and phagocytosis functions of SCs and the key regulator c-Jun will probably be a hot spot for future research. This study summarizes the current research results and predicts research trends for further research, which will facilitate researchers in quickly understanding the current state of research in the field while referring to new research directions.

Brain Connectivity: A Journal of Clinical Neurology, Neuroscience, & Neuroimaging Advancing the Field of Neurology

<i>Brain Connectivity: A Journal of Clinical Neurology, Neuroscience, &amp; Neuroimaging</i> Advancing the Field of Neurology

Global Trends and Hotspots of Transient Receptor Potential Melastatin 8 Research from 2002 to 2021: A Bibliometric Analysis.

Transient receptor potential channels are the major temperature and nociceptive receptors in the human body and transient receptor potential melastatin 8 (TRPM8) is the cold-sensitive and non-selective cation channel. In our study, we performed a bibliometric analysis of TRPM8 from 2002 to 2021 to summarize the current research status and potential research direction in the future. The TRPM8-related publications were selected from the Web of Science Core Collection SCI-EXPANDED database from 2002 to 2021. The publication details, such as authors, titles, and author keywords, were used for bibliometric analysis and network visualization to present the current state of TRPM8 research. A total of 1035 articles met the inclusion criteria. The number of TRPM8-related articles has grown rapidly over the past two decades. The USA has the largest number of publications, citations, and international collaborations. The TRPM8-related articles are mainly published and cited in neurological journals, such as the Journal of Neuroscience (41 publications and 2171 local citations). Prevarskaya N. has the most publications (26), and Patapoutian A. has been cited the most (1414 local citations). The popular disciplines in TRPM8 research include Neurosciences and Neurology, Pharmacology and Pharmacy, Biochemistry, and Molecular Biology. Research hotspots are mainly TRP channel, calcium, prostate cancer, proliferation, pain, cold, nociception, and inflammation. Our bibliometric analysis demonstrates that the number of TRPM8 studies has increased from 2002 to 2021. The global research trends and hotspots include the activation mechanism of TRPM8 in neurons, the role of TRPM8 in neuronal and non-neuronal diseases, and therapeutic target research.

Neuroscience Needs to Test Both Statistical and Scientific Hypotheses.

Experimental neuroscience typically uses "p-valued" statistical testing procedures (null hypothesis significance testing; NHST) in evaluating its results. The rote, often misguided, application of NHST (Gigerenzer, 2008) has led to errors and "questionable research practices." Although the problems could be avoided with better statistics training (Lakens, 2021), there have been calls to abandon NHST altogether. One suggestion is to replace NHST with "estimation statistics" (Cumming and Calin-Jageman, 2017; Calin-Jageman and Cumming, 2019). Estimation statistics emphasizes the uncertainty inherent in scientific investigations and uses metrics, e.g., confidence intervals (CIs), that draw attention to uncertainty. Besides procedural steps and methods, the Estimation Approach prefers expressing "quantitative," rather than "qualitative" conclusions and making generalizations, rather than testing scientific hypotheses. The Estimation Approach embodies a philosophy of science-its ultimate goals, experimental mindset, and specific aims-that diverges unhelpfully from what laboratory-based neuroscience needs. The Estimation Approach meshes naturally with, e.g., clinical neuroscience, drug development, human psychology, and social sciences. It fits less well with much of the neuroscience published in the Journal of Neuroscience, for example. In contrast, the philosophy behind NHST fits naturally with traditional, evaluative testing of scientific hypotheses. Finally, some Estimation Approach remedies, e.g., replication, ideally with "preregistration," are incompatible with much experimental neuroscience. This Dual Perspective essay argues that, while neuroscience can benefit from practical aspects of estimation statistics, entirely replacing conventional methods with the Estimation Approach would be a mistake. NHST testing should be retained and improved.SIGNIFICANCE STATEMENT Experimental neuroscience relies on statistical procedures to assess the meaning and importance of its research findings. Optimal scientific communication demands a common set of assumptions for expressing and evaluating results. Problems arising from misuse of conventional significance testing methods have led to a proposal to replace significance testing with an Estimation Statistics Approach. Practical elements of the Estimation Approach can usefully be incorporated into conventional methods. However, the prevailing philosophy of the Estimation Approach does not address certain important needs of much experimental neuroscience. Neuroscience should adopt beneficial elements of the Estimation Approach without giving up the advantages of significance testing.

Withdrawn: Giacomo Guidali, Agnese Zazio, Eleonora Marcantoni, Antonietta Stango, Guido Barchiesi, Marta Bortoletto. Effect of TMS current direction and pulse waveform on cortico-cortical connectivity: A TMS-EEG study. European Journal of Neuroscience, 2022 (https://doi.org/10.1111/ejn.15738).

The above article from European Journal of Neuroscience, published online on 15 June 2022 in Wiley Online Library (wileyonlinelibrary.com), has been withdrawn by agreement between the journal Editor-in-Chief, John Foxe, and John Wiley and Sons Ltd. The withdrawal has been agreed because the journal published the Stage 1 Registered Report in error and it is journal policy to only publish the Stage 2 Registered Report when the research has been completed. The journal apologises for this error and the inconvenience caused.

Bibliometric analysis of research on gene expression in spinal cord injury.

Spinal cord injury (SCI) is a severe disease with motor and sensory function being destroyed, which leads to a poor prognosis and a serious financial burden. It is urgent to figure out the molecular and pathological mechanisms of SCI to develop feasible therapeutic strategies. This article aims to review documents focused on gene expression in SCI and summarize research hotspots and the development process in this field. Publications of SCI-related studies from 2000 to 2022 were retrieved from the Web of Science Core Collection database. Biblioshiny was used to evaluate the research performance, core authors, journals and contributed countries, together with trend topics, hotspots in the field, and keyword co-occurrence analysis. Visualized images were obtained to help comprehension. Among 351 documents, it was found that the number of annual publications increased in general. The most productive country was China, followed by the United States with the highest influence and the most international cooperation. Plos One was the journal of the maximum publications, while Journal of Neuroscience was the most influential one. According to keyword co-occurrence and trend topics analysis, these articles mainly focused on molecular and pathological mechanisms as well as novel therapies for SCI. Neuropathic pain, axonal regeneration and messenger RNA are significant and promising research areas. As the first bibliometric study focused on gene expression in SCI, we demonstrated the evolution of the field and provided future research directions like mechanisms and treatments of SCI with great innovativeness and clinical value. Further studies are recommended to develop more viable therapeutic methods for SCI.

COMMON PRESENTATION WITH AN UNCOMMON ETIOLOGY: THYMOMA-ASSOCIATED AUTOIMMUNE ENCEPHALITIS INDUCED BY COVID-19 BOOSTER VACCINE

COMMON PRESENTATION WITH AN UNCOMMON ETIOLOGY: THYMOMA-ASSOCIATED AUTOIMMUNE ENCEPHALITIS INDUCED BY COVID-19 BOOSTER VACCINE

What the Flip? What the P-N Flip Can Tell Us about Proactive Suppression.

It has been debated whether salient distractors in visual search can be proactively suppressed to completely prevent attentional capture, as the occurrence of proactive suppression implies that the initial shift of attention is not entirely driven by physical salience. While the presence of a Pd component in the EEG (associated with suppression) without a preceding N2pc component (associated with selection) has been used as evidence for proactive suppression, the link between these ERPs and the underlying mechanisms is not always clear. This is exemplified in two recent articles that observed the same waveform pattern, where an early Pd-like component flipped to a N2pc-like component, but provided vastly different interpretations (Drisdelle, B. L., & Eimer, E. PD components and distractor inhibition in visual search: New evidence for the signal suppression hypothesis. Psychophysiology, 58, e13898, 2021; Kerzel, D., & Burra, N. Capture by context elements, not attentional suppression of distractors, explains the PD with small search displays. Journal of Cognitive Neuroscience, 32, 1170-1183, 2020). Using RAGNAROC (Wyble et al., Understanding visual attention with RAGNAROC: A Reflexive Attention Gradient through Neural AttRactOr Competition. Psychological Review, 127, 1163-1198, 2020), a computational model of reflexive attention, we successfully simulated this ERP pattern with minimal changes to its existing architecture, providing a parsimonious and mechanistic explanation for this flip in the EEG that is unique from both of the previous interpretations. Our account supports the occurrence of proactive suppression and demonstrates the benefits of incorporating computational modeling into theory building.

Designing the Application of Verbal Fluency Test in Persian for Neurocognitive Evaluations

Verbal fluency test is a useful method to evaluate cognitive executive functions. Studies have shown that both types of verbal fluency test (phonemic and semantic) are influenced by brain damage. This test is rarely used by clinicians because it takes too much time to perform. Therefore, we decided to increase its speed and accuracy by designing a verbal fluency test application in Persian language. The study on designing the application of verbal fluency test in Persian was published in the journal of Basic and Clinical Neuroscience entitled “Verbal fluency performance in normal adult population in Iran: norms and effects of age, education and gender”. To design the application, two software engineers, one programmer, and one graphic designer had cooperation with each other. First, the programming was done. During the programming, the programmer first implemented the tables related to the test. Then, by entering constant variables, an initial layout in the form of a look-up table was developed. Then, the graphic designs were added to the application. By testing 100 different scores with the relevant table and receiving the output, the accuracy of the initial version was confirmed. After designing the software, field tests were performed by 10 clinicians to evaluate the application in terms of ease of use and main structural errors. Finally, by testing 100 different scores, the accuracy of the final version was confirmed. The verbal fluency test application in Persian can increase the use of psychological and cognitive tests by Iranian clinicians by increasing the speed and accuracy of tests.

Corrigendum

European Journal of NeuroscienceVolume 56, Issue 5 p. 4699-4699 CORRIGENDUMFree Access Corrigendum First published: 02 September 2022 https://doi.org/10.1111/ejn.15795AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat In Fifield and Vanderluit (2020), in the Material and Methods, section 2.1 Animals, page 3197 it reads: “Fifty-nine male C57BL/6 mice between 3 and 6 months of age were housed and maintained on a 12:12 hr light–dark cycle with food and water provided ad libitum.” The correct information should read as follows: “Fifty-one mice between 3 and 9 months of age were included in this study. Forty-six mice were male C57BL/6, and five mice were FVBN, which included three females and two males”. The five FVBN (test) mice were inadvertently included in the 4-h and 3-day time points. The complete data set of all C57BL/6 and FVBN mice included in the study are in the supporting information. The authors sincerely apologise for these inaccuracies and any inconvenience this may have caused. Supporting Information Filename Description ejn15795-sup-0001-supporting information.xlsxExcel 2007 spreadsheet , 25.4 KB Data S1. Supporting Information Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article. REFERENCE Fifield, K. E., & Vanderluit, J. L. (2020). Rapid degeneration of neurons in the penumbra region following a small, focal ischemic stroke. European Journal of Neuroscience, 52(4), 3196– 3214. https://doi.org/10.1111/ejn.14678Wiley Online LibraryPubMedWeb of Science®Google Scholar Volume56, Issue5September 2022Pages 4699-4699 ReferencesRelatedInformation

Current Trends in the Application of EEG in Neuromarketing: A Bibliometric Analysis

Despite several neuroscience tools existing, electroencephalography (EEG) is the most used and favoured tool among researchers because of its relatively low cost and high temporal resolution. Our study aimed to identify the global academic research trends of the empirical EEG studies in neuromarketing. This paper adopted the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol to identify relevant articles. A bibliometric analysis software (VOSviewer) was used to evaluate thirty open-access articles found in the Scopus database between 2016 and 2020. We found that the USA is the most productive country with five research articles that used the EEG tool in marketing studies, followed by Australia, Italy, and Malaysia with three articles each. According to the most prolific journals in neuromarketing, it has been found that Frontiers in Neuroscience journal (CiteScore 5.4) is the most prolific journal with two articles and 25 total citations, followed by Scientific reports (CiteScore 7.1) with two articles and eighteen total citations, which lead us to infer that the publications’ number does not necessarily reflect the citations’ number. The study provides a profound and comprehensive overview of academic research that used EEG in marketing research.

APA’s Journals Celebrate Latest Impact Factors

Back to table of contents Previous article Next article APA & MeetingsFull AccessAPA’s Journals Celebrate Latest Impact FactorsSearch for more papers by this authorPublished Online:11 Jul 2022https://doi.org/10.1176/appi.pn.2022.08.7.50Clarivate Analytics has released the latest edition of its Journal Citation Reports (Clarivate Analytics, 2022), which provide journals’ latest impact factors. An impact factor is a bibliometric calculation that describes the level of importance of a journal’s published output on the scientific literature by measuring how much the work it publishes is cited by others.The American Journal of Psychiatry (AJP) remains an elite publication in all of science, as this year its impact factor rose above 19. The score can be interpreted as an average, where every article that the journal published in the reporting period (that is, during the years 2019 and 2020) was cited by more than 19 articles in 2021. This impact factor score ranks AJP among the highest not just in the category of psychiatry, but also among all the 21,430 indexed journals in scientific, technical, engineering, and medical publishing. AJP’s impact factor of 19.242 places it in the top 200 of all journal titles, ahead of 99% of the rest of the publishing world.The new impact factor for Psychiatric Services rose above 4 to 4.157. Of the journals included in the Health Policy & Services category, Psychiatric Services is the highest ranked mental health journal. Psychiatric Services is also now the #1 mental health journal in the category of Public, Environmental & Occupational Health.The impact factor for the Journal of Neuropsychiatry and Clinical Neurosciences rose this year to 2.891, its highest since 1999. ■ ISSUES NewArchived

Possible medication to treat cocaine use disorder: Rat study

A federally funded study found that some receptors in the brain, if blocked, make it harder for rats to resist seeking cocaine. OK, if there are too many negatives in that sentence, we understand. But here's another. There are no medications to treat cocaine use disorder. So the researchers, writing in the Journal of Neuroscience, suggest that these receptors, which are certain acetylcholine receptors in the lateral habenula (LHb), the part of the brain that balances reward and aversion, may represent a future target for such medications. In 2020, over 41,000 people died from drug overdoses involving stimulants, including cocaine and methamphetamine. “This discovery gives researchers a new, specific target toward solving a problem that has long been elusive: developing treatments for cocaine addiction,” said National Institute on Drug Abuse Director (NIDA) Nora Volkow, M.D. “As we have seen with medications to treat opioid use disorder, adding this tool to clinical care could save lives from overdose and drastically improve health and quality of life.” There are still challenges, as the acetylcholine receptors are “involved in everything from regulating heart rate, affecting motion sickness, and controlling vasodilation,” as some examples. “These receptors are also located throughout the body, including many other regions of the brain.” Further research is needed to develop ways to target the system “without causing a cascade of side effects,” according to NIDA.

Call for Papers: Brain Connectivity: A Journal of Clinical Neurology, Neuroscience, & Neuroimaging.

Call for Papers: Brain Connectivity: A Journal of Clinical Neurology, Neuroscience, & Neuroimaging.

Author-Initiated Retraction: Kobelt et al., "Tracking Age Differences in Neural Distinctiveness across Representational Levels".

At the request of the authors, The Journal of Neuroscience is retracting “Tracking Age Differences in Neural Distinctiveness across Representational Levels,” by Malte Kobelt, Verena R. Sommer, Attila Keresztes, Markus Werkle-Bergner, and Myriam C. Sander, which appeared on pages [3499–3511][1

Identifying the Presence of Ethics Concepts in Chronic Pain Research: A Scoping Review of Neuroscience Journals

Identifying the Presence of Ethics Concepts in Chronic Pain Research: A Scoping Review of Neuroscience Journals

The Development of GABAergic Network in Depression in Recent 17 Years: A Visual Analysis Based on CiteSpace and VOSviewer.

In this study, we analyzed the status and research trends of the GABAergic system in depression from 2004 to 2020 to provide a reference for further research. The Web of Science database was used as the data source and 1,658 publishments were included. Using two visualization analysis software, CiteSpace and VOSviewer, we analyzed the publishing years, countries, institutions, authors, journals, categories, keywords, and research frontiers in depression. The publishments revealed an upward trend from 2004 to 2020; the most prolific country and institutions were the United States and INSERM, respectively. The journal of Neuroscience was the most published and cited journal. The most relevant category was neurosciences. The hot topics in this field were GABAergic research in Gaba(a) receptor; the research frontier was depressive model. These analysis results provide a new perspective for researchers to conduct studies on related topics in the future and guidance for scientists to identify potential collaborators and research cooperation institutions.

Metaverse Games: Game Changer for Healthcare?

Cyberpsychology, Behavior, and Social NetworkingVol. 25, No. 5 EditorialMetaverse Games: Game Changer for Healthcare?Brenda K. WiederholdBrenda K. WiederholdBrenda K. Wiederhold, Editor-in-ChiefSearch for more papers by this authorPublished Online:10 May 2022https://doi.org/10.1089/cyber.2022.29246.editorialAboutSectionsView articleView Full TextPDF/EPUB Permissions & CitationsPermissionsDownload CitationsTrack CitationsAdd to favorites Back To Publication ShareShare onFacebookTwitterLinked InRedditEmail View articleFiguresReferencesRelatedDetailsCited byDİJİTAL OYUNLARIN GELECEĞİNDE METAVERSE ETKİSİ11 January 2023 | TRT AkademiUtilizing the metaverse in anatomy and physiology5 January 2023 | Anatomical Sciences Education, Vol. 63Examining the training and education potential of the metaverse: Results from an empirical study of next generation SAFe training5 January 2023 | Journal of Software: Evolution and Process, Vol. 13The Medical Metaverse, Part 1: Introduction, Definitions, and New Horizons for NeuropsychiatryThe Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 35, No. 1Pioneering the Metaverse: The Role of the Metaverse in an Aging Population20 January 2023 | JMIR Aging, Vol. 6Metaverse in Healthcare Integrated with Explainable AI and Blockchain: Enabling Immersiveness, Ensuring Trust, and Providing Patient Data Security4 January 2023 | Sensors, Vol. 23, No. 2Exploring the metaverse in the digital economy: an overview and research framework5 December 2022 | Journal of Electronic Business & Digital Economics, Vol. 1, No. 1/2The MetaPharmacy: What Happens When Big Pharma Goes Virtual? Brenda K. Wiederhold6 December 2022 | Cyberpsychology, Behavior, and Social Networking, Vol. 25, No. 12Advances in Metaverse Investigation: Streams of Research and Future Agenda29 October 2022 | Virtual Worlds, Vol. 1, No. 2The Age Beyond Sports: User Experience in the World of Metaverse30 November 2022 | Journal of MetaverseImplementation of Developed Esantem Smart Healthcare System in MetaverseApplication of Metaverse Service to Healthcare Industry: A Strategic Perspective11 October 2022 | International Journal of Environmental Research and Public Health, Vol. 19, No. 20The Trend of Metaverse and Augmented & Virtual Reality Extending to the Healthcare SystemCureus, Vol. 17The Metaverse: A New Challenge for the Healthcare System: A Scoping Review30 August 2022 | Journal of Functional Morphology and Kinesiology, Vol. 7, No. 3METAVERSE VE SAĞLIK HİZMETLERİ ÜZERİNE BİR DEĞERLENDİRME28 June 2022 | Erzincan Binali Yıldırım Üniversitesi İktisadi ve İdari Bilimler Fakültesi Dergisi Volume 25Issue 5May 2022 InformationCopyright 2022, Mary Ann Liebert, Inc., publishersTo cite this article:Brenda K. Wiederhold.Metaverse Games: Game Changer for Healthcare?.Cyberpsychology, Behavior, and Social Networking.May 2022.267-269.http://doi.org/10.1089/cyber.2022.29246.editorialPublished in Volume: 25 Issue 5: May 10, 2022PDF download

Acute Intermittent Hypoxia Improves Orthostatic Tolerance in Chronic but not Acute Spinal Cord Injured Rats

Spinal cord injury (SCI) causes hypotension and orthostatic intolerance due to disrupted sympathetic input to the heart and vasculature following injury1. A neuro‐therapeutic strategy shown to increase somatic motor function below the injury is acute intermittent hypoxia (AIH). While AIH is known to improve control over respiratory and non‐respiratory motor systems with incomplete cervical SCI2,3, cardio‐autonomic responses to AIH after SCI are unknown. In able‐bodied individuals, AIH increases blood pressure (BP), improves orthostatic tolerance (OT), and heightens sympathetic activity4. In incomplete SCI, intact neural pathways regulating sympathetic nerve activity suggest the potential for AIH to increase sub‐lesional sympathetic activity, thus improving cardiovascular function. Previous work has demonstrated that the response to AIH is greatest in rats at least 4 weeks post‐injury due to reestablishment of serotonergic pathways2, therefore the purpose of this project is to investigate whether AIH improves OT in rats following acute (2 weeks) and/or chronic (4 weeks) high‐thoracic SCI. We believe AIH will improve OT more in chronically versus acutely injured rats.12 Wistar rats underwent T3 300 kdyn SCI. At 14 (n=6) or 28 (n=6) days post‐SCI rats were tracheotomized, ventilated and arterial catheterization was performed to assess BP. Rats were subjected to lower body negative pressure (LBNP; recorded with manometer) to decrease mean arterial pressure (MAP) by 5 and 10 mmHg for 1 min. Rats were exposed to isocapnic AIH (10 x 1‐min FIO2=0.10 separated by 2 min of FIO2=1.00; targeting a PaCO2 of 40 mmHg). LBNP was repeated 90 minutes post‐AIH, the expected peak response. Blood gases were measured pre‐ and post‐AIH. A mixed‐design ANOVA was performed to examine effects of time post‐SCI (group) and AIH (treatment) on change in box pressure required to decrease MAP by ‐5 and ‐10 mmHg.There was a significant group*treatment interaction for the ‐5 mmHg (p=0.011) and ‐10 mmHg LBNP stage (p=0.017). Post hoc comparisons demonstrate that in chronic SCI the box pressure required to drop MAP by ‐5 and ‐10mmHg was increased by 41±16% (p=0.009) and 46±22% (p=0.079) versus pre‐AIH, respectively, implying improved OT (Fig 1).We demonstrate that AIH has the capacity to improve OT in a rodent model of SCI in a chronic, but not acute setting.