Neuropsychological Diagnosis Research Articles

A.R. Luria's Approach to Neuropsychological Assessment and Rehabilitation.

Luria is one of the most influential authors in cognitive neuroscience, and in particular neuropsychology. New scientific achievements and clinical observations have significantly supported many of his suggestions and hypotheses. The article describes the basic concepts of neuropsychological evaluation and rehabilitation, associated with the method of syndrome analysis developed by Luria for diagnosis mental function and focus in the qualitative interpretation of the results neuropsychological diagnosis. Luria is regarded as a pioneer in cognitive rehabilitation. His ideas have maintained relevance and have continued to be developed and analyzed. Luria is presented as one of the major founders of contemporary neuropsychology from the fundamental point of view and the clinical perspective. His influence has continued significantly during the 21st century.

NEUROPSYCHOLOGICAL REHABILITATION OF AN ADOLESCENT PATIENT AFTER INTRACRANIAL EMBOLIZATION OF AVM – A CASE STUDY

This paper discussed a case study of a 15-year-old girl who had had a hemorrhagic stroke, caused by arteriovenous malformation. A brain arteriovenous malformation is a defect in the vascular system, a tangle of abnormal blood vessels connecting arteries and veins in the brain. The patient attended regularly neuropsychological rehabilitation and several various therapeutic methods were applied. A neuropsychological diagnosis was performed before and after therapy. The first assessment showed some cognitive disturbances: difficulties in the organization of memorized material, difficulties in maintaining attention and deficits in abstract thinking. Furthermore there were observed emotional problems: depression and high perfectionism. The patient participated in individual therapy lasting one year. Neuropsychological rehabilitation took into consideration the personal psychological resources and cognitive and emotional difficulties. As a result, there was observed an improvement in consequent cognitive functions: organization of memorized material, working memory, abstract thinking and verbal fluency. The emotional state was stable. It is important that the therapy should be holistic and includes all aspects of the patient’s functioning, which may have an influence on the final result of rehabilitation. One of the most important aims of the therapy psychologist was an acceptance of the disease. The cognitive tasks can also include psychological and therapeutic exercises.

Facial agnosia in the clinical presentations of brain lesions

Facial agnosia (prosopagnosia) is one of the causes of limitations in the life of patients with focal vascular, inflammatory, traumatic, and tumor lesions of the brain; however, the clinical significance of these lesions in neurological practice is often underestimated.The review briefly presents the current understanding of the neurophysiological basis of facial gnosis and its neuroanatomic correlates. It discusses the clinical variants of prosopagnosia, the features of neuropsychological diagnosis, and adopted approaches to patient rehabilitation. It also highlights the importance of developing standardized methods for facial agnosia to improve the detection of prosopagnosia in focal brain lesions.

Cognitive Epileptiform Disintegration in Children

Cognitive epileptiform disintegration is a specific disease associated with severe epileptiform activity on the EEG in the absence of epileptic seizures accompanied by different developmental cognitive disorders in children. The quantitative and qualitative characteristics of these developmental disorders have changed in the last10 years. The article presents the analysis of cognitive epileptiform disintegration specificity and the results of the survey that included 57 children aged 2–7 with developmental disorders caused by epileptiform activity that was revealed during video EEG monitoring with sleep deprivation. The children were assessed with19-channel EEG, synchronized with a video-monitoring system. Recording time was 1–2 hours. The psychometric methods used for the assessment of cognitive functions were three batteries of tests for children according to their age (2 years – MacArthur Communicative Development Inventories, 3–5 years – subtests created in Kazan’ Federal University, 6–7 years – T.V. Akhutina’s methods of neuropsychological diagnosis). The results of the research show that cognitive impairment in children with cognitive epileptiform disintegration aged 2–7 are complex, and predominantly they are the results of general developmental disorders associated with constant strong electrical impact on the functional blocks of the brain. Speech is most severely affected, both expressive and impressive, but speech disorders are always accompanied by the deficit of visual-spatial and kinesthetic analyzers, the deficit of the third functional block development and behavioral (predominantly autism-like) disorders.
 Keywords: cognitive epileptiform disintegration, developmental disorders, speech disorders, video EEG monitoring, higher cortical functions, assessment of speech, assessment of cognitive functions

EFFECTS OF NEUROPSYCHOLOGICAL THERAPY IN A SCHOOL-AGED CHILD WITH AUTOIMMUNE DRUG-RESISTANT EPILEPSY: A CASE STUDY

The aim of this article is to present the effects of neuropsychological therapy of a school-aged child diagnosed with autoimmune drug-resistant epilepsy. Material and methods: A battery of neuropsychological and clinical tests, an interview with the patient’s mother, observational data, and the results of previous psychological and medical tests were used to provide a neuropsychological diagnosis of an 8-year-old girl. The diagnosis was performed twice: before and after a year of neuropsychological therapy. The therapy program was based on the assumptions of microgenetic symptom theory (Brown & Pąchalska 2003), which aims at improving intellectual, visuospatial, and executive functions, as well as improving the emotional - social processes. The patient’s intellectual functions significantly improved: in 2017, the quotient of fluid intelligence ranged from light intellectual disability to lower than average. Currently, the IQ ranges from lower than average to average. Improvements also took place in the following areas: motor and constructional praxis, capacity of direct auditory memory, visuomotor coordination, spatial orientation, visual searching, and some executive functions. Other cognitive processes did not change, while an increase in the difficulty in switching attention from one task to another was observed. Neuropsychological therapy conducted in accordance with the theoretical assumptions of neuropsychology proved effective. We consider that neuropsychological therapy should be continued while new goals are established.

The clinical image of memory, attention, and executive functions in a school-aged child with autoimmune epilepsy: A case study

The aim of this study was to identify specific aspects of the cognitive and socioemotional functioning of a school-age child with autoimmune-resistant epilepsy, and to provide a detailed explanation of the executive dysfunctions significant in this type of disorder. A battery of neuropsychological tests and clinical trials were used to neuropsychologically diagnose an eight-year-old girl. Data from an interview with the patient’s mother, observational data, and the results of previous psychological and medical tests were also taken account. Neuropsychological diagnosis was performed in line with the clinical–experimental and psychometric -test models. The patient’s current level of intellectual functions is below average. The patient obtained low results in tests examining executive functions, direct auditory memory, phonemic hearing, and visual–spatial organization. In comparison with children of her age group and with similar intelligence quotients, she obtained average results relating to tasks involving direct visual memory. No difficulty was seen in terms of semantic fluency, concentration, or persistence of the attention process. Executive dysfunctions are among the dominant disorders seen in clinical settings; these significantly hinder the systematic and orderly organization of the child’s learning process. Such difficulties in cognitive functioning, but also in emotional and social functioning, can significantly impede the normal development of the child.

Verbal fluency in research conducted with PET technique under conditions of extended cognitive activation with the use of 18F-fluorodeoxyglucose (FDG) tracer.

Functional neuroimaging of the brain is a widely used method to study cognitive functions. The aim of this study was to compare the activity of the brain during performance of the tasks of phonemic and semantic fluency with the paced-overt technique in terms of prolonged activation of the brain. The study included 17 patients aged 20-40 years who were treated in the past for Hodgkin'slymphoma, now in remission. Due to the type of task, the subjectswere divided into two groups. Nine people performed the phonemic fluency task, and eight semantic. Due to the disease, all subjects were subject to neuropsychological diagnosis. The diagnosis of any cognitive impairment was an exclusion criterion. Neuroimaging was performed using PET technique with 18F-fluorodeoxyglucose (FDG) tracer. Performance of a verbal fluency test, regardless of the version of the task, was associated with greater activity of the left hemisphere of the brain. The most involved areas compared with other areas of key importance for the performance of verbal fluency tasks were frontal lobes. An increased activity of parietal structures was also shown. The study did not reveal differences in brain activity depending on the type of task. Performing the test in both phonemic and semantic form for a long time, in terms of increased cognitive control resulting from the test procedure, could result in significant advantage of prefrontal lobe activityin both types of tasks and made it impossible to observe the processes specific to each of them.

Przesiewowa Skala Funkcji Poznawczych w Schizofrenii (CSSS) – Część 2: Trafność diagnostyczna metody

The present study is focused on further validation procedure of the CSSS - short screening scale designed for fast detection of persons with cognitive impairment and coexisting psychosocial disorders that demand deeper neuropsychological diagnosis and rehabilitation. 67 subjects with schizophrenia and 36 healthy controls were examined with the CSSS, BACS, PANSS, and the Global Assessment of Functioning (GAF). Relationships between the CSSS score, age and education were tested with simple linear regression in groups of 124 subjects with schizophrenia and 36 healthy controls. Numerous statistically significant (p< 0.05) relationships between the CSSS and the BACS subtests, and the CSSS and the PANSS subscales were observed. The corrected CSSS score differs GAF ? 70 group from GAF >70 group. The CSSS is a short method with satisfactory validity, that is adequate to the assumed goals and might be promising with respect to further development.

Using graphic productions in medical — neuropsychological, psychiatric and neurological — diagnosis

The problems indicated in the present publication result from various malfunctions or deficits caused e.g. by craniocerebral traumas. The sick persons struggle with num­erous consequences of such traumas which directly translate into, amongst others, the spoken and written communication process. Apsychological, neuropsychological, neuro­logical and psychiatric diagnosis is asource of valuable information about the disease progress and suspension, or the effectiveness of the implemented therapy. The application of modern research views and positions contributes to the development of more effective impacts directing and supporting patients in their endeavour to live in dignity. This publication is addressed primarily to students as ateaching aid during the forensic, criminal or civil procedure courses, but also to practitioners who – for their professional purposes – appoint handwriting experts, and who seek knowledge about handwriting research.

Analysis of the correlation between intelligence and social mood for children with expressive language disorder

Objective To explore the characteristics and correlation of intelligence development and socioemotional development in 1~3 years old children with expressive language disorder, and provide a basis for early intervention. Methods 125 cases with expressive language disorder(language disorder group) and 126 normal children (normal group) are evaluated in two parts (intelligence and social mood) with 0~6 years old neuropsychological development diagnosis scale and Chinese version of urban infant-toddler social and emotional assessment . Results (1)The scores in language disorder group were lower than normal group in the area of free movements (81.60±10.40 vs 89.62±7.94), adaptability (81.48±10.95 vs 91.25±8.89), language (67.46±7.20 vs 89.13±8.24), social behavior (76.61±9.73 vs 90.12±8.13) and total developmental quotient (80.17±6.39 vs 91.15±6.05) (P<0.05). (2) There were significant differences between language disorder group and normal group in the area of externalizing behavior(56.28±10.15 vs 53.57±7.91), deregulation (56.45±10.61 vs 51.11±9.32) and capabilities(46.79±9.08 vs 51.25±7.47) (P<0.05). The boys’ scores in internalizing behavior were lower than the girls’ (49.19±10.76 vs 54.71±9.90) (P<0.05). (3) The scores of gross motor had positive correlation with externalizing behavior (r=0.220, P<0.05). The scores of language had negative correlation with externalizing behavior and deregulation(r=-0.650, P<0.05; r=-0.470, P<0.05). The scores of social behavior had negative correlation with externalizing behavior (r=-0.208, P<0.05). There was also a negative correlation between total development and deregulation (r=-0.184, P<0.05). (4) Multiple stepwise linear regression results showed that the externalizing behavior domain and mothers’ education could predict 44.1% of variances in the language area. Conclusion The children with expressive language disorder not only show backward in level of language development, but also in the development of other areas, and also bad social behavior and emotional problems. Individualized parenting interventions should be adopted to promote these children’s intelligent development in an all-round way. Key words: Language disorder; Development quotient; Intelligence; Socioemotional

Validation of ANAM for cognitive screening in a mixed clinical sample

ABSTRACTThe Automated Neuropsychological Assessment Metrics (ANAM) is a library of computer based tests designed to measure cognitive function at a single time-point or longitudinally for detection of cognitive change. This study sought to validate ANAM as a cognitive screening tool for presence of confirmed neuropsychological diagnosis in an outpatient setting. Retrospective data analysis was conducted for 139 patients referred for outpatient neuropsychological assessment. Clinical diagnosis was made independent of ANAM test results and resulted in a diagnostic mix of both neurologic and psychologic etiologies. ANAM scores predictive of presence of confirmed diagnosis were identified using multiple logistic regression and the predictive ability of the resulting model was quantified using receiver operator characteristic analysis. Sensitivity and specificity for the ANAM when combined with anger and depressive symptom scores were 71% and 91%, respectively, with a positive predictive value of 97.5 and negative predictive value of 40.4. This combined approach provided the greatest accuracy for individual tests as well as the composite score of the ANAM in identifying those who received a subsequent clinical diagnosis. Although data should be replicated in larger samples, these results suggest that ANAM may have predictive value and may be a useful screening tool for identifying those who would likely benefit from neuropsychological services.

Decline in changing Montreal Cognitive Assessment (MoCA) scores is associated with post-stroke cognitive decline determined by a formal neuropsychological evaluation.

ObjectivesWe aimed to examine changes in the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores within a one-year period after stroke/transient ischemic attack (TIA) in associating cognitive decline determined by a formal neuropsychological test battery.MethodsPatients with ischemic stroke/TIA received MoCA and MMSE at baseline within 14 days after stroke/TIA, at 3–6 months and 1-year follow-ups. The scores of MoCA and MMSE were considered to have declined if there were a reduction of ≥2 points in the respective scores measured across two time points. The decline in neuropsychological diagnosis transitional status was defined by a category transition from no cognitive impairment or any cognitive impairment to a more severe cognitive impairment or dementia.Results275 patients with a mean age of 59.8 ± 11.6 years, and education of 7.7 ± 4.3 years completed all the assessments at baseline, 3–6 months and 1-year follow-ups. A decline in MoCA scores from 3–6 months to 1 year was associated with higher risk of decline in diagnosis transitional status (odd ratio = 3.21, p = 0.004) in the same time period whereas there was no association with a decline in MMSE scores.ConclusionsThe decline in MoCA scores from 3–6 months to 1 year after stroke/TIA has three times higher risk for decline in the diagnosis transitional status. The decline of MoCA scores (reduction ≥ 2points) is associated with the decline in neuropsychological diagnosis transitional status.

DYNAMICS OF COGNITIVE FUNCTION OF PATIENTS WITH DEFECTS OF THE SKULL AFTER RECONSTRUCTIVE SURGERY

Due to the high social significance of traumatic brain injury and its consequences, dynamics of cognitive functions at the background of the reduction of reconstructive and plastic surgery is of interest to researchers in the world, but this topic is not sufficiently studied. A large number of patients with bone defects of the skull due to a traumatic brain injury and skull defects after surgery for tumors, and as a consequence of possible cognitive deficits of these patients makes it necessary to study and assess the possibility of its compensation as a result of reconstructive plastic surgery of the skull. Material and methods. In our study, we examined 54 patients (12 women and 42 men) in surgical treatment neurotrauma department (reconstructive surgery) after traumatic brain injury or skull defect after surgical removal of tumors. The average age of patients is 33,09 years. All patients were examined by a psychologist before surgery, and on the first, third, and seventh-eighth day after the surgery. MoCA, FAB, Schulte tables, HADS, Spielberger-Hanin anxiety test, a set of stimulus materials for neuropsychological diagnosis, all patients were asked to subjectively evaluate their appearance: until defect acquisition prior to surgery after treatment (see questionnaire by Sinbukhova E.[8]), also was used projective drawing method, where patients were asked to perform a series of drawings on the given topics. In our study to reduce the high level of situational and personal anxiety of the patients they had Art-therapy sessions with a psychologist before surgery and from the second day after it. The purpose of research is to study the changes in cognitive function, level of depression, anxiety of patients with postoperative bone defects of the skull after a reconstructive-plastic surgery. Keywords cognitive function, depression, anxiety, reconstructive surgery. Results On the 3 days after surgery, a statistically significant increase was observed in the evaluation acording MoCA (preoperative mean value — 22 points, 3 days after the operation — 24 points, p = 0,0002033). Before сheck out (MoCA) significant improvement in cognitive function was confirmed. Depression, personal and situational anxiety was significantly reduced by the time сheck out. By the time of сheck out the emotional state of the patients showed significant improvement of emotional state level to the level prior to the defect acquisition. Subjective evaluation of appearance by the time of сheck out of patients showed a significant recovery of subjective apearance evaluation of the level prior to the defect acquisition. Conclusion. The obtained data revealed a statistically significant increase of early postoperative cognitive function of the background of reconstructive-plastic surgery. Statistically significant results of the reduction of depression, situational and personal anxiety, improvement of the emotional state of patients after surgery, at the background of daily Art-therapy (projective drawing) sessions with a psychologis.

The utility of the Luria Battery for Neuropsychological Diagnosis of Adults

espanolActualmente existen diferentes herramientas basadas en el enfoque de evaluacion neuropsicologica de Luria, pero los datos empiricos sobre las poblaciones espanolas son limitados. El objetivo principal de este estudio es revisar evidencias cientificas sobre las propiedades psicometricas del Luria Diagnostico Neuropsicologico de Adultos (Luria DNA). Este estudio agregativo revisa sistematicamente 14 investigaciones cientificas (articulos y tesis doctorales) utilizando la “Luria DNA”. De acuerdo con esta revision, la bateria “Luria DNA” permite detectar cambios neuropsicologicos en personas con diferentes tipos de patologias y discapacidad intelectual. Sin embargo, las evidencias normativas y clinicas son aun escasas. Se hacen necesarias futuras investigaciones para aclarar la sensibilidad y la especificidad de esta bateria para discriminar entre personas mayores con deterioro cognitivo y personas cognitivamente sanas. EnglishCurrently there are various tools based on Luria’s neuropsychological assessment approach, but the empirical data on Spanish populations are limited. The main objective of this study is to review the scientific evidence on the psychometric properties of the Luria Spanish Battery for the Neuropsychological Diagnosis of Adults (Luria DNA). This aggregative study systematically reviews 14 scientific investigations (articles and doctoral dissertations) that use the Luria DNA. According to this review, the Luria DNA battery allows the detection of neuropsychological changes in people with different types of pathologies and intellectual disability. However, the normative evidence and clinical data are still scarce. Further investigations are needed in order to clarify the sensitivity and specificity of this battery in discriminating between older individuals with cognitive impairment and those that are cognitively healthy.

Нейропсихологический метод в дифференциальной клинико-психологической диагностике когнитивных нарушений у детей и подростков с психической патологией

The article describes the neuropsychological techniques which are applied in the clinical practice in child psychiatry. It describes a system of qualitative and quantitative neuropsychological diagnostics. The role of neuropsychological analysis of the cognitive deficits associated with schizophrenia spectrum disorders in children and adolescents is reflected. Hierarchical cluster analysis according to neuropsychological diagnosis helps in the establishing the psychiatric diagnosis.

Validation of the International HIV Dementia Scale as a Screening Tool for HIV-Associated Neurocognitive Disorders in a German-Speaking HIV Outpatient Clinic.

BackgroundHIV-associated neurocognitive disorders (HAND) are widely present among people living with HIV. Especially its milder forms, asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorder (MND), remain highly prevalent worldwide. Diagnosing these conditions is subject to a time and resource consuming neuropsychological assessment. Selecting patients at a higher risk of cognitive impairment by using a simple but effective screening tool helps to organise access to further neuropsychological diagnosis. The International HIV Dementia Scale (IHDS) has until now been a well-established screening tool in African and American countries, however these populations’ demographics defer significantly from ours, so using the same parameters could be ineffective.ObjectivesTo calculate the prevalence of this condition among people attending an HIV outpatient clinic in Berlin and to validate the use of the IHDS as a screening tool for HAND in a German-speaking population.MethodsWe screened 480 HIV-infected patients using the IHDS, 89% of them were on a stable antiretroviral treatment. Ninety of them completed a standardised neuropsychological battery of tests and a specific cognitive complaints questionnaire. The same procedure was applied to a control group of 30 HIV-negative participants. HAND diagnosis was established according to the Frascati criteria.ResultsThe overall prevalence of HAND in our cohort was 43% (20% ANI, 17% MND and 6% HIV-associated dementia). The optimal cut-off on the IHDS for detecting HAND cases was set at 11 and achieved both a sensitivity and a specificity of 80%. When specifically screening for the more severe form of HAND, HIV-associated dementia, a cut-off value of 10 offered an increase in both sensitivity (94%) and specificity (86%). The Youden Index for diagnostic accuracy was 0.6 and 0.8, respectively.ConclusionsThe prevalence of HAND was comparable to the reported by recent studies performed in countries with a similar economic development. The study confirms the IHDS to be a useful HAND screening tool in primary care settings and establishes new recommendations for its use in German-speaking countries.

So Close Yet So Far: Executive Contribution to Memory Processing in Behavioral Variant Frontotemporal Dementia.

Memory impairment in behavioral variant frontotemporal dementia (bvFTD) is traditionally considered to be mild and attributed to prefrontal cortex dysfunction. Recent studies, however, indicated that some patients can present with a memory impairment of the hippocampal type, showing storage and consolidation deficits in addition to the more executive/prefrontal related encoding and strategic difficulties. This study aimed to study the relationship between executive functions (EF) and memory processes in bvFTD via a data-driven approach. Participants consisted of 71 bvFTD (among which 60.6% had a lumbar puncture showing non-Alzheimer biomarker profile) and 60 controls (among which 45% had amyloid imaging showing a normal profile). EF were assessed by the Frontal Assessment Battery, semantic/lexical verbal fluency tests, and forward/backward digit spans. Patients were split into amnestic (n = 33) and non-amnestic (n = 38) subgroups based on normative data (total recall score) from the Free and Cued Selective Reminding Test (FCSRT). Relationships between FCSRT subscores and EF measures were explored through hierarchical clustering analysis, partial correlation analysis with an EF component, and automated linear modeling. Convergent findings across the statistical approaches show that, overall, memory performance was independent from EF in bvFTD whereas the relationship was stronger in controls. Indeed, in bvFTD, memory performance did not cluster with EF, was not correlated with the EF component, and was only partially (4% - 12.7%) predicted by EF. These findings show that executive dysfunctions cannot solely explain the memory deficits occurring in bvFTD. Indeed, some patients present with a genuine amnesia affecting storage and consolidation abilities, which are independent from executive dysfunctions. On the clinical level, this study highlights the importance of revising the neuropsychological diagnosis criteria for bvFTD.

Neurocognition in patients with schizophrenia

Abstract Objective The article presents the current state of knowledge on diagnosis, rehabilitation and pharmacological treatment of neuropsychological impairment in schizophrenia. Review Cognitive functioning is moderately to severely impaired in patients with schizophrenia. There is a growing number of diagnostic methods translated into Polish that enable mental health professionals to evaluate and describe cognitive deficits. Some available tools include: MATRICS Consensus Cognitive Battery (MCCB), Brief Cognitive Assessment Tool for Schizophrenia (B-CATS), Montreal Cognitive Assessment (MoCA) and Brief Assessment of Cognition in Schizophrenia (BACS). There is also an increasing number of rehabilitation programmes that support therapy of cognitive impairment such as Social Cognition and Neurocognition Training, RehaCom, COGPACK and Neuroforma. Conclusion The use of current knowledge, accurate neuropsychological diagnosis, the use of an appropriate cognitive rehabilitation programme and pharmacotherapy may have a significant impact on quality of life and functioning of patients with schizophrenia.

Brazilian Normative Data on Letter and Category Fluency Tasks: Effects of Gender, Age, and Geopolitical Region.

Verbal fluency is a basic function of language that refers to the ability to produce fluent speech. Despite being an essentially linguistic function, its measurements are also used to evaluate executive aspects of verbal behavior. Performance in verbal fluency (VF) tasks varies according to age, education, and cognitive development. Neurodevelopmental disorders that affect the functioning of frontal areas tend to cause lower performance in VF tasks. Despite the relative consensus that has been reached in terms of the use of VF tasks for the diagnosis of dyslexia and attention-deficit/hyperactivity disorder, few studies have considered regional variations in Brazil. The present study sought to provide normative data on VF tasks in children by considering gender, age, education, and geopolitical region of origin with auxiliary purposes in neuropsychological diagnosis of disorders that occur with executive changes The study included 298 participants, 7–10 years of age of both genders, who performed three letter fluency tasks and three category fluency tasks. The data were subjected to correlational and variance analyses, with age and gender as factors. No effect of gender on the children's performance was found. However, significant differences between age groups were observed, with better performance in letter tasks in older children and better performance in letter tasks compared with category tasks. Significant regional differences in performance on the letter VF task were observed. These results reinforce the importance of regional normative data in countries with high regional cultural variations, such as Brazil.

Clinical and neurophysiological assessment of cognitive functions during the treatment of patients with chronic brain ischemia

Purpose. To develop the optimal combination of methods of neuropsychological and neurophysiological diagnosis for objectification of cognitive function in patients with chronic brain ischemia, the reasoning of differentiated selection of criterias for complex treatment that includes medication and non-pharmacological methods for patient’s recovery and professional adaptations. Materials and methods. 30 patients were examined. To all of them was conducted clinical and neurological examination, MRI, neuropsychological testing using a scale (HADS, MoCA, professional maladjustment, MBІ), ultrasound of head and neck vessels, electroencephalography (EEG) with mapping, registration of cognitive auditory evoked potentials (CEP) P300. Results. The most pronounced changes were registered in units of optical-spatial perception (30%), math skills (23%), short-term memory (30%), (p &lt;0,05). In 70% of cases- registered professional maladjustment symptoms (p &lt;0,05). Patients of the I-st group with hypertensive changes at the main arteries of the head and neck (according to ultrasound) marked a significant change in the parameters of the CEP: 85% decrease in an amplitude and increase in latency of P300 peak, reduction of the amplitude of the peak N2; in 66% of cases was reduced only peak amplitude N2. Was determined the relationship between the results of the neuropsychological and neurophysiological methods and cerebral blood flow in patients with chronic brain ischemia. Conclusion. There was developed a complex method of comprehensive neurophysiological (NP) and neuropsychological (NP) testing of the cognitive functions tha provides an objective evaluation of pathological changes in mnestical/intellectual capabilities of the patient, such as attention, memory, professional adaptation in patients with chronic brain ischemia.