Neuromuscular Tension Research Articles

Safranal exerts a neuroprotective effect on Parkinson's disease with suppression of NLRP3 inflammation activation.

Parkinson's disease (PD) is a common central nervous system neurodegenerative disease. Neuroinflammation is one of the significant neuropathological hallmarks. As a traditional Chinese medicine, Safranal exerts anti-inflammatory effects in various diseases, however, whether it plays a similar effect on PD is still unclear. The study was to investigate the effects and mechanism of Safranal on PD. The PD mouse model was established by 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine MPTP firstly. Next, the degree of muscle stiffness, neuromuscular function, motor retardation and motor coordination ability were examined by observing and testing mouse movement behavior. Immunofluorescence staining was used to observe the expression of tyrosine hydroxylase (TH). The dopamine (DA) content of the striatum was detected by High-performance liquid chromatography (HPLC). The expression of TH and NLRP3 inflammasome-related markers NLRP3, IL-1β, and Capase-1 were detected by Real-time Polymerase Chain Reaction (qRT-PCR) and western blotting (WB) respectively. Through behavioral testing, Parkinson's mouse showed a higher muscle stiffness and neuromuscular tension, a more motor retardation and activity disorders, together with a worse motor coordination compared with sham group. Simultaneously, DA content and TH expression in the striatum were decreased. However, after using Safranal treatment, the above pathological symptoms of Parkinson's mouse all improved compared with Safranal untreated group, the DA content and TH expression were also increased to varying degrees. Surprisingly, it observed a suppression of NLRP3 inflammation in the striatum of Parkinson's mouse. Safranal played a neuroprotective effect on the Parkinson's disease and its mechanism was related to the inhibition of NLRP3 inflammasome activation.

Evaluation of Physiotherapy Impact on Neuromuscular Tension in Analog Astronauts at the LunAres Habitat.

The evaluation of manual Trigger Point Therapy (TrPt) on mandible abduction range of Analog Astronauts (AA) surviving isolation conditions during consecutive missions at the LunAres Habitat was performed. This physiotherapy method was applied to decrease stress-related neuromuscular tension. Abduction measurements were conducted on the two groups of five AA, who endured severe isolation conditions for 14 days in the limited space of the LunAres Research Station Habitat (Piła, Poland) during missions. The test group consisted of abduction measurements of AA who received TrPt and control group of abduction measurements of AA who did not receive TrPt. All measurements were noted in the TemporoMandibular Joint (TMJ) diagnosis aspect of the integrated dental examination card SZOPPDP©. The ischemic compression was performed on an active localized trigger point—resulting in cessation of pain. Maximum abduction measurements were made with an electronic caliper, and the abduction range was compared. The change of abduction range in AA with TrPt was bigger than in AA without TrPt. A larger increase in abduction range was observed in every case in the group receiving TrPt compared to the control group. TrPt effectively decreases the neuromuscular tension, which results in an increased mandibular abduction range of AA. Observations conducted in LunAres Research Station regarding stress-related neuromuscular tension can help identify effective therapeutic methods for circumstances of social isolation.

A conceptual review on pretreatment anxiety management in a dental setting using hypnosis and progressive muscle relaxation

Dental anxiety is associated with the thought or idea of seeing the dentist and undergoing dental procedures. Anxiety-associated problems in the dental setting include avoidance of appointments, inability to provide successful dental care, and delay in optimal recovery. Anxiolysis is important to the level of being mandatory for suitable administration of dental care. Since times immemorial, dentists have struggled to manage anxiety successfully by employing changing concepts and strategies over time. Pharmacological modalities to allay anxiety-like sedation and general anesthesia are popular yet associated with an added cost per patient, side effects, expensive armamentarium, documentation, and patient monitoring. Non-pharmacological modalities for anxiety management have been employed over time but have limited nature of success. The use of hypnosis as a therapeutic modality for healing and resolving anxiety is known for over five thousand years and has been a part of many cultures over time. Progressive Muscle Relaxation, which was documented first in 1908 is based on the principle of releasing neuromuscular tension in the body which creates a state of emotional equilibrium. In the present paper, an in-depth review of the techniques i.e. Hypnosis and Progressive Muscle Relaxation is provided from the perspective of a dental clinician from historical evolution to practical recommendations. Both Hypnosis and Progressive Muscle Relaxation hold promise to be adjunct tools in the modern dentist’s armamentarium to manage anxiety.

РОЛЬ ПСИХОЭМОЦИОНАЛЬНОЙ СФЕРЫ В ПОВЫШЕНИИ СПОРТИВНОГО МАСТЕРСТВА КВАЛИФИЦИРОВАННЫХ СПРИНТЕРОВ

One of the insufficiently studied problems of ensuring the continuous growth of sports achievements of short-distance runners is the maintenance of their positive psycho-emotional state. The emotional sphere, along with motor and vegetative functions, takes a significant place in solving problems of determining new approaches to improving the effectiveness of the competitive activity of qualified sprinters. Striving for a record result requires high neuromuscular tension, often exceeding the athlete’s capabilities. This puts the psychological training of athletes to one of the leading places. The authors have developed a methodology for managing the psycho-emotional sphere of short-distance runners, taking into account genetic and culturally determined components. The results of the pedagogical experiment showed that psychological training provides physical, technical and theoretical readiness of sprinters for competition.

The preclinical studies of the stress-protective activity of “Tonus-aktiv” homeopathic granules

Aim. To perform the preclinical studies of the stress-protective activity of a new “Tonus-Aktiv” homeopathic medicinal product.Materials and methods. The stress-protective effect of the “Tonus-Aktiv” homeopathic medicinal product (MP) and the reference drug – “Stress-gran” homeopathic granules were studied on the model of neuromuscular tension by Selye. The stress-protective effect of the drugs was assessed by the conventional methods described in the scientific literature and the corresponding current instructional guidelines. All factual material was processed by variational statistics methods using parametric (Newman-Keuls test) and non-parametric methods of analysis (Kruskal-Wallis, Mann-Whitney).Results and discussion. It was found that “Tonus-Aktiv” had a pronounced gastro-protective effect, reducing the area of ulcers by almost 3 times, having a statistically significant antioxidant effect, reducing the level of TBA (thiobarbituric acid) active products in the liver homogenate. It did not have a normalizing effect on the protein metabolism, but it did contribute to enhancing energy-supplying metabolic processes: aerobic glycolysis indicated by a reliable increase of the pyruvic acid level in the blood serum, and lipolysis, as evidenced by a significantly higher level of the total blood lipids. “Tonus-Aktiv” showed a pronounced antioxidant activity: it reduced the TBA level of active products in the liver homogenate. At the same time, the level of endogenous antioxidant of reduced glutathione was observed to be lower than in the stressed animals against the background of the “Tonus-Aktiv” application. It indicates the physiological nature of the stress protective activity of the drug.Conclusions. A moderate stress-protective activity of “Tonus-Aktiv” homeopathic granules can be observed; it is caused by antioxidant properties, as well as a probable activating effect on the hypothalamic-pituitary-adrenal system, which may be manifested by the protective action.

Changes in the upper airway following induction of anaesthesia: a prospective observational study protocol to determine the use of ultrasound in the assessment of a difficult airway in China

IntroductionDifficult airway management is closely related to the safety and quality of medical care. However, the low incidence of correct prediction of difficult airway in clinical screening tests presents physicians...

THE INFLUENCE OF MELANIN ON THE GASTRIC MUCOSA AND HYPOTHALAMIC-PITUITARY-ADRENOCORTICAL AXIS UNDER ACUTE STRESS CONDITIONS

We studied the influence of melanin from yeast-like fungi Nadsoniella nigra strain X1 on the changes of the levels of adrenocorticotropic hormone (ACTH) and cortisol in blood serum of rats, adrenal glands weight ratio and lesions of the gastric mucosa (GM) caused by neuromuscular tension by Selye. Melanin administration restored functioning of the hypothalamic-pituitary-adrenal axis that was evident by an increase of ACTH concentration by 42% and a decrease of cortisol concentration by 19% compared to the rats injected with water (group 2). In rats treated with melanin, the adrenal glands weight ratio, didn't differ from intact control group of the rats. Melanin decreased ulcers area by 64% and reduced the content of free hydroxyproline by 29%, the free fucose by 16% and the free hexuronic acids by 24% in the GM compared to the group 2 of the rats. It is established that the mechanism of melanin stress-protective properties are based on its regulation of the glucocorticoids secretion and prevention of GM collagen and extracellular matrix substances depolymerization. Melanin possesses gastroprotective properties and is a perspective agent for preventing and treatment of consequences of the stress influence on the organism.

Особливостi лейкоцитарної формули кpoвi щурiв за умов стрес-iндукованих ерозивно-виразкових уражень шлунка та профiлактичного введення меланiну

lt was studied the influence of melanin from yeast-like fungi Nadsoniella nigra strain Xl from vertical cliffs оn the island Galindez (Antarctica) on the features of rat white blооd count under neuromuscular tension bу Selye. After stress it was observed increase of the neutrophils percentage аnd decrease lymphocyte percent of rats blооd. Prophylactic administration of melanin restored the functioning of the immune system, which was confirmed bу neutrophils percent decrease and lymphocyte percentage increase according to the stress group. The results suggest attenuation of inflammation under the influence of а test compound in stress conditions.

Scientific evidence reveals conjoined etiology in spinal deformation and the need for etiology based treatment. Insight in a trail

Effects of discongruent growth on the spine and central cord morphology gained attention in Orthopedics. If growth is dependent on exogenic factors and neuromuscular tension, therapy must focus on reversal of this. An extensive search on clues in existing literature was done. Goal was to formulate consequences for treatment strategies.

Gender determines the effect of atracurium priming technique in a randomized study

To evaluate the effect of priming atracurium over onset time and intubating time of general anesthesia between different genders. Sixty-six male and sixty-four female patients, ASA I-II, aged 18-65 years, were randomly divided into four groups: group M1: male patients with saline priming; group M2: male patients with priming atracurium dose of 0.05 mg/kg; group F1: female patients with saline priming; group F2: female patients with priming atracurium dose of 0.05 mg/kg. General anesthesia was induced with midazolam(0.1 mg*kg(-1)) propofol(0.75 mg*kg(-1)), intubation dose of atracurium (0.5 mg*kg(-1)), fentanyl (3 μg*kg(-1)). The incidences of dizziness, diplopia, heavy eyelids and dyspnea were observed. Neuromuscular tension was quantified by using TOF-Guard neuromuscular monitor, and intubating time was defined as the duration from the infusion of intubation dose of atracurium to the time when T4/T1=0. The intubating time of group F2 was shorter than that of group F1. There was no significant difference between group M1 and group M2. The incidences of dizziness, diplopia and heavy eyelids in group F2 were higher than those in group M2. Atracurium priming technique could shorten the intubation time of female patients, but not for male patients, and the gender plays a key role in affecting the clinical outcome of atracurium priming.

Clinical detectable tension in the growing body: new and revisited aspects in (de-)formation of the growing spine. Can lordotic bracing technique be seen as neuromuscular tension regulation in stead of osseous correction?

Clinical detectable tension in the growing body: new and revisited aspects in (de-)formation of the growing spine. Can lordotic bracing technique be seen as neuromuscular tension regulation in stead of osseous correction?

Reduction of Neuromuscular Hypertension for Improvement of Athletic Performance

This study investigates the inhibition of neuromuscular tension in specific key muscles, for the purpose of increasing athletic efficiency. Four golfers were studied electromyographically during the backswing. Integrated EMG findings from the right wrist flexors showed a significant decrease following application of passive stretch. The theoretical and practical aspects of this technique are discussed. J Orthop Sports Phys Ther 1984;5(6):384-390.

Effects of Active and Passive EMG Biofeedback Training on Performance of Motor and Cognitive Tasks

The goal of this study was to compare the effects of general relaxation (passive group) and neuromuscular tension control (active group), both using EMG biofeedback techniques, on the performance of memorization, simple reaction time, and rotary pursuit. 18 subjects were given five consecutive daily sessions of training or were placed under control conditions, after which their performance on these various tasks was evaluated. Results indicate that control of neuromuscular tension seemed to facilitate performance on all tasks over that of the control group. Except for simple reaction time, there was no difference between the "active" and "passive" groups. The results are interpreted in terms of factors in selection of subjects and experimental conditions.

Deconditioning by the use of EMG signals

This paper describes the use of a miniature EMG circuit in deconditioning neuro-muscular tension. The circuit is described and its use illustrated by reference to a patient who suffered with pain in the jaws. This evidence suggests that the treatment was beneficial and the possibility of using this type of biofeedback is briefly discussed.

Relaxation and neuromuscular tension control and changes in motor performance under induced tension.

The purpose of this study was to determine the effects of specific instructions in relaxation and neuromuscular tension control on changes in the performance of a motor test under stress. The motor test was throwing darts at a specific target for speed and accuracy. Stress was induced by a verbal threat of failure. GSR, respiration rate, and EMG recordings were obtained from each S on initial and final tests. The verbal threat produced stress in all Ss ( p = .01). Ss in the exercise control group had a significantly lower respiration rate than the other Ss. The experimental treatment given to the relaxation group did not have a significant influence in reducing neuromuscular tensions during the performance of the motor test.

Relaxation and neuromuscular tension control and changes in mental performance under induced tension.

The purpose of this study was to determine the effects of specific instructions in relaxation and neuromuscular tension control on changes in the performance of a memorization test under stress. The memorization test required recall of random numbers. Stress was induced by a verbal threat. GSR, respiration rate, and EMG recordings were obtained from each S on initial and final tests. Ss who were taught to control neuromuscular tension performed significantly better on the final test than Ss who were not taught to control neuromuscular tensions.

Behavior Factors in Handwriting Identification

Dr. med. A. Naftali is a lecturer in criminalistics at Faculty of Law, The Hebrew University of Jerusalem, Israel and also a practicing physician in Jerusalem. Dr. Naftali's medical studies were carried on in Germany and Italy. They were interrupted in 1934 because of political developments in Europe and only completed in 1959. His research for his dissertation dealt with neuro-muscular tension in handwriting before, during, and after psychotherapy and was carried out at the psychosomatic clinic in Hamburg under Professor Jores. In the interim between his medical studies, Dr. Naftali served for ten years in the scientific branch of CID, Jerusalem, as a document examiner. In 1948 he was appointed head of the Criminal Identification Bureau and Laboratories of the Israel Police from which he resigned in 1953. His present paper was presented at the First International Meeting of Questioned Documents, London, 1963.-EDITOR.

Diagnosis of mandibular joint dysfunction

The material used in this investigation has consisted mainly of 186 cases examined and treated by me. The case histories and the results of clinical and roentgenographic examinations are recorded on a standard form, and an analysis of the findings indicates that female patients, particularly in the 20- to 30-year age group, predominate. In the majority of cases pain is the symptom which prompts the patient to seek treatment, and pain is most frequently experienced in the region of the joint itself. Malocclusion in one form or another was found in approximately one-half of the patients, but only a small proportion of these had overclosure. Although malocclusion was present in these cases, it was frequently considered a contributory rather than a primary etiological factor. Neuromuscular tension and trauma were frequently responsible for mandibular joint dysfunction. Rheumatoid arthritis, varying from mild atypical forms to the progressive crippling form, probably attacks the mandibular joint more often than is generally supposed, although there are usually accompanying etiological factors which render the joint more susceptible to rheumatic involvement. Etiological factors are placed as far as possible into primary and contributory categories. In most cases methods of treatment to be employed depend upon the factors considered responsible for symptoms. The differential diagnosis of mandibular joint dysfunction is made easier by the use of a standard form for recording case histories and clinical findings. Certain conditions which may present difficulties in differential diagnosis are discussed.

Electromyographlcal Studies on The Effects of Noise (1)

The present paper deals with physiological influences of noise on the neuromuscular system. This experiment was carried out upon 18 human beings. They were exposed to noise (113db, 600-800cps), and neuromuscular potentials were measured at 21 muscles before and during exposure by surface electrodes. The following results were obtained : 1) There were some evidences of increments of the neuromuscular tension during exposure to noise in 14.7% of the muscles of 18 individuals. 2) Muscles which responded relatively frequently were M. masseter, M. sacrospinalis and M. gastrocunemius. 3) The responses seemed to appear more frequently in muscles in contraction rather than in resting state. 4) It was suggested that many factors in individual senitivities were contributing to the response.

Modificationsélectro-encéphalographiques, électro-dermographiques et électro-myographiques provoquées par la chlorpromazine chez l'homme

The authors have studies the electroencephalograms (EEG), electrodermograms (EDG) and electromyograms (EMG) in 2 neurotics, 2 psychotics, 5 psychomotor epileptics, 1 case of petit mal, 1 patient with autonomic epilepsy, 1 case of post-encephalitic Parkinson, and in 1 patient suffering from generalised tic, during and after the slow intra-venous injection of chlorpromazine (4560 RP) from 25 to 50 mg. They observed that in 8 cases of “activated EEG pattern” occurs the synchronization and regularization of the EEG record where the frequencies were nearly normal, i.e. alpha rhythm appeared. In 6 cases with epileptic discharges (5 temporal and 1 petit mal) a clear activation of such discharges were noted. In the normal records, no important modification occurred. The stabilisation of the EDG was observed in every case after the injection of the drug. This was evidenced by the disappearance of oscillations in response to different sensory stimuli, including nociceptive stimuli. In patients with involuntary electromyographic activity, (exaggerated neuro-muscular tension, tics, tremor), a decrease or total disappearance of such activity was seen during the half hour following the injection of chlorpromazine. These results and observations are compared with recent electro-physiological findings and discussed in view of the probable central action of chlorpromazine on the brain stem reticular system. Finally chlorpromazine is proposed as a method of activation in some cases of epilepsy and also for the elimination of artifacts provoked in EEG records in cases presenting involuntary movements.