Palliative care, in pediatric age, is a comprehensive approach to treatment that guarantees patients and their families a whole healing process from diagnosis to death. The techniques used for neurologic patients in the field of palliative care can enhance the quality of care provided to all patients with neurologic disorders and support their families. Our goal was to analyze palliative care protocols in use in our departments, describing the palliative course in our clinical setting and to present a proposal that allows implementation of hospital palliative care patients with neurologic diseases with a long-term prognosis. In this retrospective observational study, we present our experience in the application of palliative care for neurologic patients from birth to early infancy. We studied 34 newborns with diseases affecting the nervous system, causing impairment of the prognosis. The study was conducted from 2016 to 2020, in Neonatology Intensive Care Unit and the Pediatric Unit of the San Marco University Hospital in Catania, Sicily, Italy. Despite the legislative rules, no palliative care network has been activated to meet the needs of the population. In our center, given the vast number of patients with neurologic conditions requiring palliative care interventions, it can be suggested to activate a straightforward departmental unit for neurologic pediatric palliative care. The establishment of specialized reference centers that deal with significant neurological illnesses is due to the progress of neuroscience in recent decades. Integration with specialized palliative care is sparse but now seems essential.