Neurological Complications In Patients Research Articles

Peripheral Neuropathy in Long-Term Diphenylhydantoin Therapy

SINCE the introduction of diphenylhydantoin by Merritt and Putnam¹in 1938, it has been the drug of choice in the treatment of many forms of epilepsy. Serious sideeffects of long-term administration have been rare. There has not been a comprehensive study of neurological complications in patients on long-term diphenylhydantoin therapy. Peripheral neuritis and myelopathy associated with megaloblastic anemia have been reported.^2-5The precise role of diphenylhydantoin in the pathogenesis of neurological involvement in these cases is not clear. Some of the patients were anemic and malnourished; one had evidence of malabsorption.² It has been recognized by clinicians working with patients on prolonged diphenylhydantoin therapy that a loss of deep tendon reflexes, particularly in the legs, can occur. This has not been documented in the literature and no detailed study of nerve conduction in patients receiving diphenylhydantoin has been reported. Our attention was drawn to this problem

CENTRAL NERVOUS SYSTEM COMPLICATIONS FOLLOWING BLALOCK-TAUSSIG OPERATION

Two cases of severe neurologic symptoms after a Blalock-Taussig anastomosis are presented in detail. The histories of 116 patients with cyanotic congenital heart disease who had such an anastomotic operation at the Mayo Clinic were reviewed. There was a low incidence (less than 1%) of postoperative neurologic complications in patients without evidence of focal dysfunction of the central nervous system prior to operation. The review suggested an increased incidence of complications in those patients with a cerebrovascular abnormality before surgery. It is likely that these complications are related to alterations in the vertebrobasilar arterial system associated with this procedure.

Neurologic complications in patients with coarctation of aorta.

Neurologic complications in patients with coarctation of aorta.

The pathogenesis and management of neurological complications in patients with malignant lymphomas and leukemia.

The pathogenesis and management of neurological complications in patients with malignant lymphomas and leukemia.

STUDIES IN HODGKIN'S DISEASE

Article1 December 1936STUDIES IN HODGKIN'S DISEASEIII. CLINICAL APPLICATION OF THE GORDON TEST (A SYNDROME OF ATAXIA, SPASM AND PARALYSIS INDUCED IN RABBITS BY THE INTRACEREBRAL INJECTION OF EMULSIFIED HODGKIN'S TISSUE)*EARLE M. CHAPMANEARLE M. CHAPMANSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-10-6-742 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe description by Gordon1, 2in 1932 of a biological test for Hodgkin's disease aroused widespread interest. Van Rooyen3in Scotland made a trial of the test and later, in a paper published in this country, van Rooyen and Olgivie4expressed the opinion that it had proved itself to be of definite clinical value. Our own evaluation of this test as a diagnostic aid in the differentiation of the Hodgkin's type of lymphoblastoma is presented here after three years of experience in which material from 16 cases of Hodgkin's disease and 30 cases of other types of lymphadenopathy has been...Bibliography1. HORDER T: Rose research on lymphadenoma, 1932, John Wright and Sons, Ltd., London. Google Scholar2. GORDON MH: Remarks on Hodgkin's disease, Brit. Med. Jr., 1933, i, 641. CrossrefGoogle Scholar3. VAN ROOYEN CE: Some properties of the encephalitogenic agent in lymphadenomatous tissue, Brit. Med. Jr., 1934, i, 519. CrossrefGoogle Scholar4. OLGIVIEVAN ROOYEN RFCE: Value of Gordon's test in diagnosis of mediastinal Hodgkin's disease, Jr. Am. Med. Assoc., 1934, cii, 1842. Google Scholar5. FRIEDEMANN U: The pathogenic agent in normal human bone marrow, Brit. Med. Jr., 1934, i, 517. CrossrefGoogle Scholar6. MACKENZIEVAN ROOYEN ICE: Relationship of Jochmann's and other enzymes to the encephalitogenic agent in lymphadenomatous lymphatic glands, Brit. Med. Jr., 1935, i, 406. CrossrefGoogle Scholar7. HANSON MH: Biological phenomena in Hodgkin's disease, Minnesota Med., 1935, xviii, 263. Google Scholar8. VAN DER HOEDENHULST JLA: De Ziekte van Hodgkin en de Proef van Gordon, Nederl. Tijdschr. v. Geneesk., 1934, lxxviii, 4305. Google Scholar9. JOCHMANNLOCKEMANN GG: Hofmeister's Beitrage, 1908, ii, 449. Google Scholar10. BRONFENBRENNER JJ: On the particulate nature of bacteriophage, Jr. Exper. Med., 1927, xlv, 873. CrossrefGoogle Scholar11. KELSERKING RALS: Studies of a paralysis syndrome in rabbits and guinea pigs by extracts of normal primate bone marrow, Am. Jr. Path., 1936, xii, 317. Google Scholar12. GOLDSTEIN JD: The "Gordon test" for Hodgkin's disease, Am. Jr. Med. Sci., 1936, cxci, 775. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication August 27, 1936.From the Department of Pathology and the X-Ray Treatment Clinic.†Dalton Scholar, Massachusetts General Hospital, Boston, Mass. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byThe pathogenesis and management of neurological complications in patients with malignant lymphomas and leukemiaObservation on the nature of Gordon's encephalitogenic agentOBSERVATIONS ON THE CELLULAR BASIS OF THE GORDON TEST FOR LYMPHADENOMADiscussion on the Ætiology and Diagnosis of Lymphadenoma 1 December 1936Volume 10, Issue 6Page: 742-747KeywordsBrainClinical trialsHodgkin lymphomaLesions Issue Published: 1 December 1936 PDF downloadLoading ...