You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Basic Research1 Apr 2011749 NEUROPHYSIOLOGY OF THREE PHASES OF CORPORAL RELAXATION ELICITED BY ELECTRICAL FIELD STIMULATION ON RABBIT CORPUS CAVERNOSUM SMOOTH MUSCLE Chen Zhao, Jai Seong Cha, and Jong Kwan Park Chen ZhaoChen Zhao Jeonju, Korea, Republic of More articles by this author , Jai Seong ChaJai Seong Cha Jeonju, Korea, Republic of More articles by this author , and Jong Kwan ParkJong Kwan Park Jeonju, Korea, Republic of More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.1774AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Many studies demonstrated that electrical field stimulation (EFS) caused rapid but transient smooth muscle relaxation and NO was shown to mediate relaxations in response to nerve stimulation. As we have known that the neural control of penile erection involves the adrenergic, cholinergic, and nonadrenergic-noncholinergic (NANC) neuroeffector systems. However, the effects of EFS on adrenergic and cholinergic nerves are not clear. In our study, we verified the EFS-NO pathway in in vitro penile chamber strip model and penile perfusion model. We discovered an extraordinary phenomenon that the tracing elicited by EFS presented three phases when increasing the recording speed. The objective of the present study was to elucidate the phases. METHODS EFS was performed on phenylephrine (PhE) pre-contracted penile corpus cavernosum smooth muscle from male New Zealand White rabbits. The intrinsic nerves were field-stimulated electrically (voltage, 30 V; pulse duration, 1 ms; trains of pulses, 10 seconds; train interval, 3–5 min; frequency, 0.5–32 Hz). We also investigated the penile tracing elicited by EFS (voltage, 30 V; pulse duration, 1 ms; frequency, 8 Hz) on guanethidine (Guan), tetrodotoxin (TTX), nitro-L-arginine-methyl ester (L-NAME), atropine or eserine pre-incubated tissues. RESULTS We obtained consilient results from both models. Phase I was abolished by L-NAME. Phase II was significantly decreased by eserine and Guan but increased by L-NAME. Phase III was abolished by atropine but enhanced by eserine and Guan. TTX diminished all the three phases. CONCLUSIONS The results indicated that EFS stimulated adrenergic, cholinergic, and NANC neuroeffector systems simultaneously. Phase I was related to the NO pathway. Phase II was multiply affected by self-recovery property, adrenergic nerve and cholinergic nerve. Phase III was related to cholinergic nerve. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e301 Peer Review Report Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Chen Zhao Jeonju, Korea, Republic of More articles by this author Jai Seong Cha Jeonju, Korea, Republic of More articles by this author Jong Kwan Park Jeonju, Korea, Republic of More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...