Abstract

AbstractCALCIUM is a divalent cation, ubiquitous in its biological occurrence, important in its physiological significance. It is an ion of particular interest to investigators of neural and neuro-effector systems. Reviews have appeared that cite the role of calcium in excitation-contraction coupling of striate muscle (Sandow, 1965) and in the maintenance of the nerve membrane during nervous transmission (Abood, 1967). The intention of this review will be to summarize the various experimental evidences that implicate calcium in its role as a necessary factor in the processes of neurohumoral and neurohormonal extrusion. The diversity of physiological foci considered has meant that the discussion could not feasibly cite all primary references. Consequently, an attempt has been made, when applicable, to note recent and well prepared reviews.

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