Purpose Due to mitigate against natural disasters like earthquake and to distribute relief items, designing humanitarian relief chain networks is an attentional issue. Agile and efficient distribution of relief items after occurring a disaster is significant, especially when some of the relief items are perishable. Therefore, the purpose of this paper is to create a resilient and integrated decision-making structure to distribute relief items at demand points, considering two dimensions of sustainability, under disruption. Design/methodology/approach This study developed a mixed-integer nonlinear mathematical model to handle the pre- and post-disaster planning when a disaster occurs. The represented model has two objective functions: minimizing weighted unmet demand and total costs. Therefore, to convert this multi-objective problem into a single objective one, the e-constraint method was applied. Findings The main results showed that considering some resilience strategies has a significant effect in reducing the weighted amount of unmet demand and saves the total costs. More precisely, considering resilience strategies results in a 60% reduction in total unmet demand and 11% reduction in total pre-positioning costs. On the other hand, reducing the maximum response time with applying resilience strategies is another achievement of the present study. For these reasons, the use of these strategies can reduce people’s pain and suffer from natural disasters. In general, the application and effectiveness of sustainability dimensions and resilience strategies in the introduced humanitarian relief chain network were analyzed. Practical implications To verify the applicability of this study, this model is applied on a probable real-life case study in Tehran. Finally, some managerial insights are discussed to help humanitarian organizations, managers and stakeholders to make better decisions to reduce negative effects of natural disasters. Originality/value This paper introduced a two-stage stochastic mathematical model for designing a resilient humanitarian relief chain network under disruption, at pre- and post-disaster stages. Also, economic and social dimensions of sustainability are considered in this study. Moreover, assembling perishable and im-perishable relief items as relief kits, dynamically is a main contribution of this research.
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